Results 51 to 60 of about 28,279,407 (312)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Knowledge, Attitudes And Practices Regarding The Use Of Antibiotics. Study On The General Population Of Mureş County, Romania

Infection and Drug Resistance, 2019
Septimiu Voidăzan,1 Geanina Moldovan,2 Lavinia Voidăzan,3 Ancuța Zazgyva,4 Horațiu Moldovan5 1Department of Epidemiology, University of Medicine, Pharmacy, Sciences and Technology of Tîrgu Mureş, Tîrgu Mureş, Romania; 2Department of Community
Voidăzan S, Moldovan G, Voidăzan L, Zazgyva A, Moldovan H   +4 more
doaj  

Multi-scale models for T cell activation [PDF]

, 2010
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 2010.Cataloged from PDF version of thesis.Includes bibliographical references.The overarching theme of this thesis is to develop and apply multi-scale computational ...
Zheng, Huan, Ph.D. Massachusetts Institute of Technology
core  

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Science and Technology (S&T) Legislative Landscape: Mapping State-Level S&T Legislation in the US

, 2011
Atlanta Conference on Science and Innovation Policy 2011The Office of Policy Analysis and Research at the Georgia Tech Research Institute collects,analyzes and classifies state-level legislation on various science and technology topics across the country.
Hayslett, Marlit, Kim, Moon, Petrakieva, Elena   +2 more
core   +1 more source

Russian Science and Technology Foresight – 2030: Key Features and First Results

Foresight and STI Governance, 2012
This paper reviews national features in the general evolution of science and technology (S&T) foresight over the last decade. Foresight has made a transition from thematic papers and policy briefs to a complex set of methods integrated in the framework ...
Alexander Sokolov, Alexander Chulok
doaj   +1 more source

Did the UK Digital Design and Technology (DD&T) programme lead to innovative curriculum change within secondary schools? [PDF]

, 2013
Design and technology (D&T) requires teachers to continually update their knowledge and skills, with regard to new technologies, appropriate to the needs of the time (Design and Technology Association, 2011).
Rutland, M, Davies, S
core  

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

A Ternary Hybrid Perceptron Branch Predictor for Ternary Pipelined Architectures

IEEE Access
Ternary systems are attracting attention as a next-generation technology capable of overcoming the limitations of binary systems. Ternary logic includes a third intermediate logic state, offering fundamental advantages in increasing information density ...
Seonghoon Kim, Hanmok Park, Semin Park, Sunmean Kim, Taigon Song   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source