Results 71 to 80 of about 5,743,561 (311)
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
OAST space power technology program [PDF]
The current research and technology (R and T) base program is first described, then special attention is directed toward outlining a new system technology specifically oriented toward providing the utility power plant technology base for semi-permanent ...
Mullin, J. P.
core +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
From knowledge to wealth : transforming Russian science and technology for a modern knowledge economy [PDF]
Russia possesses a sophisticated science and technology (S&T) infrastructure (research capability, technically trained workforce, and technical research universities) which, even today, is a world leader in many fields.
Watkins, Alfred
core
, 2022 White Paper for Snowmass 2022, 8 pages, 2 tables, 1 ...
Ambrosio, Giorgio +9 more
openaire +2 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Development Strategies in Medical Education, 2017 Introduction: In order to meet the social accountability, the Minimum capabilities of general practitioners in Iran have been developed by the Council of general medical education.
Esmaeil Managheb, Fatemeh Mosalanejad
doaj
NASA's Role in Aeronautics: A Workshop. Volume 4: General aviation [PDF]
A substantially improved flow of new technology is imperative if the general aviation industry is to maintain a strong world position. Although NASA is the most eminently suited entity available to carry out the necessary research and technology ...
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Phase B: Final definition and preliminary design study for the initial Atmospheric Cloud Physics Laboratory (ACPL), a spacelab mission payload [PDF]
A preliminary identification of the Supporting Research and Technology (SR&T) necessary during the planned evolution of atmospheric cloud physics is discussed. All requirements are for subsequent flights over its expected ten year lifetime.
core +1 more source