Results 61 to 70 of about 5,743,561 (311)

Tailoring capsid-directed evolution technology for improved AAV-mediated CAR-T generation

Molecular Therapy
Chimeric antigen receptor (CAR) T cell (CAR-T) therapies present options for patients diagnosed with certain leukemias. Recent advances of the technology included a method to integrate the CAR into the T cell receptor alpha constant (TRAC) locus to take advantage of the endogenous promoter and regulatory elements for CAR expression.
Adrian Westhaus, Elena Barba-Sarasua, Yuyan Chen, Kenneth Hsu, Suzanne Scott, Maddison Knight, Florencia Haase, Santiago Mesa Mora, Benjamin C. Houghton, Ramon Roca-Pinilla, Predrag Kalajdzic, Geraldine O’Neill, Adrian J. Thrasher, Giorgia Santilli, Leszek Lisowski   +14 more
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The consequence of school performance measures – inequality of access and opportunity [PDF]

, 2017
This paper assesses the potential impact of two performance measures on equality of access to a general education for all pupils. It argues that government policy, which on the surface appears to facilitate equality of opportunity, is in fact ...
Hardy, A
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

THE ATTITUDES OF TEACHERS AND SPECIAL EDUCATORS TOWARDS THE USE OF COMPUTERS AND MODERN TECHNOLOGY IN TEACHING CHILDREN WITH DEVELOPMENTAL DISABILITIES

Research in Education and Rehabilitation
The goal of education is to provide favorable conditions for creativity, cooperation, actualization, and flexibility in order to prepare students for active work and functioning in society. This is especially important for inclusive education as students
Aleksandra Bašić, Dragana Maćešić Pterović, Bojana Arsić   +2 more
doaj   +1 more source

Department of Homeland Security Science and Technology Directorate: Developing Technology to Protect America [PDF]

, 2009
In response to a congressional mandate and in consultation with Department of Homeland Security's (DHS) Science and Technology Directorate (S&T), the National Academy conducted a review of S&T's effectiveness and efficiency in addressing homeland ...
Barry Bozeman, Caroline Purdy, Cindy L. Williams, David F. Garrison, Louise K. Comfort, Sally T. Hillsman   +5 more
core  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Revisit the Classification of General Purpose Technologies (GPTs) in Corporate Innovation Research Using Patent and Patent Citation Data [PDF]

, 2015
Information and Communication Technologies (ICTs) have been recognized as a type of General Purpose Technologies (GPTs), and thus are considered t h e “driving force” in corporate technology advance.
Catwell, John, Qiu, Ranfeng
core   +1 more source