Results 81 to 90 of about 28,279,407 (312)

The green development effect of science and technology financial policy in China

open access: yesFrontiers in Environmental Science
Green development, as a key link in the philosophy of new development, is the only way to achieve sustainable development. However, how science and technology (S&T) finance affects green development remains unclear.
Xuxin Zou, Jiadi Min, Shuang Meng
doaj   +1 more source

Course Catalogue of the Massachusetts Institute of Technology 2000-2001 [PDF]

open access: yes, 2000
Massachusetts Institute of Technology Bulletin 2000-2001. Courses and Degree Programs Issue. Includes general information on the Institute; campus life; undergraduate and graduate education; academic procedures and institute regulations ...
​​Massachusetts Institute of Technology
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Course Catalogue of the Massachusetts Institute of Technology 2003-2004 [PDF]

open access: yes, 2003
Massachusetts Institute of Technology Bulletin 2003-2004. Courses and Degree Programs Issue. Includes general information on the Institute; campus life; undergraduate and graduate education; academic procedures and institute regulations ...
​​Massachusetts Institute of Technology
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

A study of maladjustment in the class of 1955 at M. I. T.

open access: yes, 1955
Thesis: B.S., Massachusetts Institute of Technology, Department of General Engineering, 1955by Arnold Langberg.B.S.B.S.
Langberg, Arnold.
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Course Catalogue of the Massachusetts Institute of Technology 1973 - 1974 [PDF]

open access: yes, 2012
The Massachusetts Institute of Technology Bulletin 1973-1974. Courses and Degree Programs Issue. Includes information on general institute requirements and requirements for graduate degrees; departmental programs and requirements; interdisciplinary study
Massachusetts Institute of Technology.
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A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Course Catalogue of the Massachusetts Institute of Technology 1938 - 1939 [PDF]

open access: yes, 2012
Massachusetts Institute of Technology Bulletin, Catalogue Issue 1938. Annual course catalogue for the 1938-1939 academic year. A Bulletin of general information about the Institute, Its government, staff, regulations, requirements for admission ...
Massachusetts Institute of Technology.
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

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