Results 141 to 150 of about 4,388 (281)

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Ethyl Cellulose-Coated Cylindrical Granules for Multi-Unit Sustained-Release Tablets: Trade-Off Between Coating Integrity, Compressibility, Tabletability, and Drug Release. [PDF]

Pharmaceutics
Li Z, Fan Y, Yang J, Zhang G, Fu Q.
europepmc   +1 more source

A study of the compressibility of directly compressible tableting materials for matrix tablets with ascorbic acid.

, 2016
This thesis evaluates and compares compressibility of directly compressible tableting materials for the preparation of matrix tablets containing ascorbic acid. Avicel® PH 102 was used as the dry binder. The hydrophilic matrix tablets contained carbomers (
Mačková, Hana
core  

Accelerated drug development using a digital formulator and a self-driving tableting data factory. [PDF]

Nat Commun
Abbas F, Salehian M, Hou P, Moores J, Goldie J, Tsioutsios A, Tait T, Portela V, Boulay Q, Thiolliere R, Stark A, Schwartz JJ, Guerin J, Maloney AGP, Moldovan AA, Reynolds GK, Mantanus J, Clark C, Chapman P, Florence A, Markl D.   +20 more
europepmc   +1 more source

The impact of medication shortages on paediatric care: A retrospective impact analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims Medication shortages are a growing global concern, with potentially greater consequences in paediatric patients because of the limited availability of safe, evidence‐based and appropriately formulated medication. This study aimed to evaluate the impact of medication shortages on paediatric patients by assessing the suitability and safety of ...
Maaike Johanna Rutten ‐ van Kranenburg, Laurens Christiaan van Rijn, Elisabeth Johanna Ruijgrok, Sinno Henricus Paulus Simons, Brigitta Carolina Maria Witjes, Jan‐Dietert Christoffer Brugma, Robert Bernard Flint   +6 more
wiley   +1 more source

Twenty years of inhaler therapy: A nationwide drug utilization study

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to map nationwide trends and prescribing patterns in inhaler use from 2004 to 2023. In light of evolving clinical guidelines and attention to the environmental impact of inhalers within recent years, we also examined variation in prescribing behaviour and patient‐level treatment choices. Methods Using nationwide health registries,
Katrine Bitsch Johansen, Lars Christian Lund, Zandra Nymand Ennis, Andrew Scourfield, Anders Løkke, Sidsel Arnspang Pedersen   +5 more
wiley   +1 more source

Pharmaceutical development of composition of effervescent tablets with acetylsalicylic acid, paracetamol, and ascorbic acid. [PDF]

Pharm Sci Adv
Panysheva O.
europepmc   +1 more source

Systemic menopausal hormone therapy treatment patterns in Danish women—A nationwide drug utilization study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Objectives This paper aims to describe the treatment patterns of contemporary systemic menopausal hormone therapy (MHT) in Denmark. Study design This study is a nationwide drug utilization study including an open cohort of all Danish women aged >40 years between 2000–2024.
Hannah K. Wood‐Kurland, Kathrine Kold Sørensen, Amalie Lykkemark Møller, Lina Steinrud Mørch, Mikkel Porsborg Andersen, Thomas Alexander Gerds, Amani Meaidi, Christian Torp‐Pedersen   +7 more
wiley   +1 more source

Next-generation probiotic delivery: Engineering complex coacervation systems for targeted gut release and bioactive synergy. [PDF]

Curr Res Food Sci
Wu W, Zhang L, Chen R, Li D, Lai J, Liao E, Xu W, Xu J, Yuan Y.   +8 more
europepmc   +1 more source

Incident low‐dose quetiapine use in adults newly diagnosed with depression in primary care: A nationwide register‐based study

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to investigate the incidence of low‐dose quetiapine initiation and associated factors in adults newly diagnosed with depression in primary care. Methods We obtained medication dispensing records, primary and secondary care diagnoses and employment status for antipsychotic‐naïve individuals aged 16–65 newly diagnosed with ...
Laura Purra, Heidi Taipale, Miia Tiihonen, Markku Lähteenvuo, Jari Tiihonen, Aleksi Hamina   +5 more
wiley   +1 more source