Results 171 to 180 of about 2,257 (250)

Clinical Characterization of Enzyme and Transporter Precipitants to Evaluate Drug–Drug Interactions for Orforglipron, a Small Molecule Glucagon‐Like Peptide‐1 Receptor Agonist

Clinical Pharmacology &Therapeutics, EarlyView.
Orforglipron is an orally administered, small‐molecule glucagon‐like peptide‐1 receptor agonist in clinical development for the treatment of type 2 diabetes and obesity. Orforglipron is a substrate of CYP3A4, organic anion transporting polypeptides (OATPs) 1B/1B3, and P‐glycoprotein (P‐gp); however, precipitants commonly used to define these mechanisms
Bridget L. Morse, David E. Coutant, Xiaosu Ma, Sohini Raha, Keerthan Aithal, Clare Nicoll, Luc R. A. Rougée, Shobha Bhattachar   +7 more
wiley   +1 more source

Interaction-Based Model to Predict Tensile Strength of Compacted Mixtures from Individual Component Data. [PDF]

Mol Pharm
Valekar P, Buckner IS.
europepmc   +1 more source

Characterization of the Immune Response after Oral Cholera Vaccination (OCV) and Effects of Mycophenolate Mofetil on Priming of this Immune Response—A Randomized, Placebo‐Controlled Trial

Clinical Pharmacology &Therapeutics, EarlyView.
Mycophenolate mofetil (MMF) is an immunosuppressive drug widely used by solid organ transplant recipients. Although it is known that MMF suppresses immune responses, its exact effects on specific vaccinations have not been investigated yet. Mucosal vaccinations are increasingly used, such as a cholera vaccination consisting of two oral immunizations ...
Boukje C. Eveleens Maarse, Aliede E. in 't Veld, Hendrika W. Grievink, Manon A.A. Jansen, Matthijs Moerland   +4 more
wiley   +1 more source

Transitioning Amiodarone Tablet Manufacturing: A Comparative Study of Batch and Continuous Wet Granulation. [PDF]

Pharmaceuticals (Basel)
Yoon JH, Jeon CW, Kim JE.
europepmc   +1 more source

Tramadol Co‐Administration with Oxycodone or Hydrocodone Increases Opioid Burden without Improving Postoperative Pain Control

Clinical Pharmacology &Therapeutics, EarlyView.
Tramadol is frequently co‐prescribed with oxycodone or hydrocodone after surgery under the assumption that its dual mechanism of action provides an opioid‐sparing benefit. However, evidence supporting this practice is limited and inconsistent. We conducted a secondary analysis of the multicenter IGNITE ADOPT‐PGx pragmatic trial of patients undergoing ...
Noor A. Nahid, Ahmed I. Soliman, Jordan F. Baye, Natasha J. Petry, Chancellor F. Gray, Rachel A. Myers, Erica N. Elwood, Elizabeth C. Harris, Hrishikesh Chakraborty, Simona Volpi, Renee Rider, Paul R. Dexter, Josh F. Peterson, Todd C. Skaar, Hari K. Parvataneni, Larisa H. Cavallari, Julie A. Johnson, on behalf of the IGNITE Pragmatic Trial Network Investigators, L Orlando, D Voora, C Horowitz, C Horowitz, N Calman, T Skaar, T Skaar, P Dexter, T Skaar, P Dexter, J Johnson, L Cavallari, J Johnson, L Cavallari, J Johnson, L Cavallari, K Blake, K Blake, K Blake, J Peterson, J Peterson, K Cavanaugh, R Singh, R Singh, L Hines, C Wyatt, H Chakraborty, Rishi Chakraborty, Christina Wyatt, Geoff Ginsburg, Kady‐Ann Steen‐Burrell, Bhargav Adagarla, Sarah George, Beth Harris, Jaclyn Holland, Yashika Johnson, Phyllis Kennel, Kristen Linney, Rania Metry, Rachel Myers, Wanda Parker, Gayle Passmore, Carol Pereira, Teji Rakhra‐Burris, Deepak Voora, Ryanne Wu, Teji Rakhra‐Burris, Azita Sadeghpour, Ruth Lehan, Tyffany Locklear, Carol Horowitz, Michelle Ramos, Sabrina Clermont, Bart Ferket, Kenneth Fifer, Diane Hauser, Joseph Kannry, James Murrough, Aniwaa Owusu Obeng, Janet Seo, Tatiana Sabin, Nandini Shroff, Saskia Shuman, Todd Skaar, Paul Dexter, Abi Colwell, Amy Breman, Zeru Desta, Cathy Fulton, Jennelle Hodge, Sheryl Lynch, Jonathan Oliver, Vicky Pratt, Ross Robinson, Elizabeth Rowe, Jennifer Stuart, Emma Tillman, Ashely Vetor, Julie Johnson, Larisa Cavallari, Alexander Parker, Erica Elwood, Kathryn Blake, Emily Cicali, Kelsey Cook, Karam Diaby, Julio Duarte, Ben Duong, Karla Giron, Elizabeth Eddy, Julia Krutov, Carol Mathews, Haesuk Park, Robyn Nelson, Ryan Rhoden, Caroline Schlierle, Taylor Sullivan, Almut Winterstein, Kristen Wiisanen, Josh Peterson, Kerri Cavanaugh, Sara Van Driest, Sara Block, Jordan Baye, Michelle Benck, Chantel Bender, Sylvia Eluhu, Colette Free, Shane Gonnelly, Sarah Hedeen, Lindsay Hines, Steve Houtschilt, Michelle Liu, Salisha Marryshow, Nicole Neville, Natasha Petry, Sidd Pratap, Vernon Sherden, Rajbir Singh, Kimberly Snell. Ana Tomescu, Megan Trietsch, James Walker, Deanna Web, Erin Whiting, Russ Wilke, Simona Volpi, Sarah Hutchison, Natalie Kucher, Ebony Madden, Jessica Reinach, Renee Rider, Ismail Safi, Ella Samer, Lori Orlando, Deepak Voora, Azita Sadeghpour, Lani Banez, Lisa Bendz, Jackie Jordan, Ruth Lehan, Tyffany Locklear, Ann McGee, Christina Nix, Lorraine Vergara, Ryanne Wu, Carol Horowitz, Michelle Ramos, Sabrina Clermont, Tyler Colon, Aaishah Francis, Samantha Guagliardo, Najiba Khan, Camila Tan Lam, Michelle Sciarrino, Emma Maiman‐Stadtmauer, Sofia Medina‐Pardo, Tatiana Sabin, Janet Seo, Lola) Williams, Rishi Chakraborty, Christina Wyatt, Geoff Ginsburg, Sheng Luo, Kady‐Ann Steen‐Burrell, Kevin Anstrom, Bhargav Adagarla, Alicia Ellis, Stephen Ellis, Sarah George, Beth Harris, Jaclyn Holland, Yashika Johnson, Phyllis Kennel, Hwasoon Kim, Kristen Linney, Peter Merrill, Rania Metry, Rachel Myers, Wanda Parker, Gayle Passmore, Carol Pereira, Teji Rakhra‐Burris, Lilin She, Jennifer Shepherd, Saira Siddiqui, Jun Wen, Todd Skaar, Abi Colwell, Brittany Davis, John Howard, Alia Jamison, Lydia Joyner, Ellie Kiihne, Sheryl Lynch, Johnathan Oliver, Ross Robinson, Libbie Silverman, Jordan Sonneville Jennifer Stuart, Laurel Tokar, Ashley Vetor, Neil Calman, Saskia Shuman, Daviana Buck, Nicole Canchucaja Porshia Cook, Ariel Jacobs Danielle John, Samantha Guagliardo, Diane Hauser, Mimi) Milanes, Wambui Ngari, Nandini Shroff, Rajbir Singh, Megan Triestch, Abraham Garcia, Carol Gutierrez, Steven Houtschilt, Maria Lopez, Alan Mejia, Anaite Montes Bu, Deanna Webb, Sonja White, Kathryn Blake, Ben Duong, Taylor Sullivan, Ali Brewer, Kelsey Cook, Brittni Deadrick, Julia Krutov, Lindsay Hines, Jordan Baye, Colette Free, Michelle Benck, Shane Gonnelly, Sarah Hedeen, Alexis Meyer, Blair Svennes, Larisa Cavallari, Erica Elwood, Hana Al Alshaykh, Tala Basha, Emily Cicali, Asia Cobb, Brendon Cooper, Elizabeth Eddy, Amanda Elchynski, Amanda Elsey, Anuksha Gotmare, Karla Giron, Lauren Lemke, Arielle Nelson, Robyn Nelson, Michael Read, Ryan Rhoden, Genevieve Rosier, Isabella Schultz, Chiara Chermont Spina, Joshua Terrell, Alexa Valko, Precious Williams, Tracy Leonard, David Smith, Marian Davis, Vincent Guerra, Jennifer Salo, Claudia Cartaya Torres, Jorge Valedon, Paola Nieves Viana, Alexander Parker, Jose Alonso, Jeffery Gainer, Morgan Howard, Fatoumata Kaba, Brianna Rivers, Liliana Serrano, Kimberly Vigal, ADeia Williams, Josh Peterson, Kerri Cavanaugh, Sara Van Driest, Sara Block, Chantel Bender, Angelo Lazaro, Salisha Merryshow, Nicole Neville, Henry Ong, Erin Whiting   +302 more
wiley   +1 more source

Evaluation of the Potential of Novel Co-Processed Excipients to Enable Direct Compression and Modified Release of Ibuprofen. [PDF]

Pharmaceutics
Aleksić I, Glišić T, Ćirin-Varađan S, Djuris M, Djuris J, Parojčić J.   +5 more
europepmc   +1 more source

Viral Dynamic Model‐Informed Dose Selection of Mosnodenvir Prophylaxis against DENV‐3 in a Controlled Human Infection Model

Clinical Pharmacology &Therapeutics, EarlyView.
Dengue virus (DENV) infection is a significant global health threat. Mosnodenvir (JNJ‐64281802) is a pan‐serotype small molecule antiviral blocking DENV replication. A Phase IIa study (NCT05048875) evaluated the antiviral activity, safety, and pharmacokinetics of mosnodenvir as prophylaxis against DENV‐3 in a controlled human infection model (CHIM).
Nele Goeyvaerts, Xavier Woot de Trixhe, Martine Neyens, Thomas N. Kakuda, Liesbeth Van Wesenbeeck, Annemie Buelens, Freya Rasschaert, Anna Durbin, Oliver Ackaert   +8 more
wiley   +1 more source

From Field to Pharmacy: Isolation, Characterization and Tableting Behaviour of Microcrystalline Cellulose from Wheat and Corn Harvest Residues. [PDF]

Pharmaceutics
Medarević D, Čežek M, Knežević A, Turković E, Barudžija T, Samardžić S, Maksimović Z.   +6 more
europepmc   +1 more source

Digital Transformation in Work Integration Social Enterprises: Leadership Strategies and the Role of Internal Stakeholders

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Digital transformation is increasingly reshaping how social enterprises organize work, engage stakeholders, and pursue social value. While prior research has examined digitalization in hybrid organizations, limited attention has been paid to how responsibility for inclusive digital transformation is enacted internally.
Riccardo Maiolini, Federica D’Alessandro, Paolo Landoni   +2 more
wiley   +1 more source

Comprehensive Powder Rheological Characterization of Fifteen Lactose-Based Co-Processed and Single-Component Excipients Using FT4 Powder Rheometry and European Pharmacopoeia Methods: A Multi-Parameter Comparative and Correlative Study. [PDF]

Pharmaceutics
Röttig M, Wolf B, Zwanzig J, Herz F, Priese F.   +4 more
europepmc   +1 more source