Results 171 to 180 of about 2,240 (251)

Statistical-Based Optimization of Modified Mangifera indica Fruit Starch as Substituent for Pharmaceutical Tableting Excipient. [PDF]

Polymers (Basel)
Chaksmithanont P, Bangsitthideth K, Arunprasert K, Patrojanasophon P, Pornpitchanarong C.   +4 more
europepmc   +1 more source

NMDAR‐antibody encephalitis: Seizure semiology and EEG findings

Epileptic Disorders, EarlyView.
Abstract Background N‐methyl‐D‐aspartate receptor antibody encephalitis (NMDAR‐Ab‐E) is an autoantibody‐mediated disorder, characterized by acute development of neuropsychiatric symptoms, seizures, movement disorders, and autonomic instability. Objectives To describe acute seizure semiology and electroencephalogram (EEG) findings in patients with a ...
Maria Emilia C. Andraus, Bernard Liem, Sidra Aurangzeb, Mkael Symmonds, Adam E. Handel, Sarosh R. Irani, Arjune Sen   +6 more
wiley   +1 more source

Investigation of differences in mechanisms of die filling between a compaction simulator and a rotary press. [PDF]

Int J Pharm X
Kohlhaas B, Finke JH.
europepmc   +1 more source

A phase 3, randomized clinical trial of soticlestat as adjunctive therapy for Lennox–Gastaut syndrome

Epilepsia, EarlyView.
Soticlestat as adjunctive therapy for Lennox–Gastaut syndrome. Abstract Objective There remains a need for new treatments for Lennox–Gastaut syndrome (LGS), a developmental and epileptic encephalopathy with a heterogenous patient population that often requires polytherapy. The phase 3, randomized SKYWAY study (NCT04938427) investigated the efficacy and
Renzo Guerrini, Eric D. Marsh, Wei‐Ping Liao, Katsumi Imai, Ruzica Kravljanac, Anna Altmann, Cecil D. Hahn, Stéphane Auvin, Jimmy Schiemann, Yasir Khan, Pranab Mitra, Sarah I. Sheikh, Philipp von Rosenstiel, Mahnaz Asgharnejad, Dennis Dlugos, Venkatesha Murthy   +15 more
wiley   +1 more source

Assessment of the plasticity of dry granulated particles (mini-tablets) and its relationship to their tabletability. [PDF]

Int J Pharm X
Tofiq M, Alderborn G, Nordström J, Persson AS.   +3 more
europepmc   +1 more source

An n‐of‐1 gene‐directed drug repurposing trial for an ultrarare genetic condition

Epilepsia, EarlyView.
Abstract Objective Gain‐of‐function (GoF) variants in the KCNC1 potassium channel subunit gene (Kv3.1) cause motor/cognitive delays and hypotonia and have been associated with seizures. Fluoxetine has inhibitory effects on Kv3.1. However, open‐label nonrandomized administration is insufficient to guide clinical decision‐making in ultrarare conditions ...
Vedika Jha, Christina Tsetsos, Mark Bedford, Gregory Costain, Sunita Vohra, Juan Pablo Diaz Martinez, Elise Heon, Jacob Vorstman, Carolina Gorodetsky, Ajoy Vincent, Jesiqua Rapley, Lori Anderson, Evdokia Anagnostou, Danielle A. Baribeau   +13 more
wiley   +1 more source

Interaction-Based Model to Predict Tensile Strength of Compacted Mixtures from Individual Component Data. [PDF]

Mol Pharm
Valekar P, Buckner IS.
europepmc   +1 more source

Do witnesses of functional/dissociative seizures recall them accurately? A UK experimental study of semiology recall at clinically relevant time points with a pilot intervention

Epilepsia, EarlyView.
Abstract Objective Different causes of transient loss of consciousness (TLOC) carry distinct risks and require different management. Early accurate diagnosis is essential to guide counseling, investigation, and referral. In routine practice, frontline clinicians and specialists often rely on eyewitness accounts, yet the reliability of witness testimony
Adam John Noble, Steven Lane, Amina Al‐Khaddar, Annabelle Blundy, Brenna Dubois, Chloe Pearce, Laszlo Sztriha, Graham Powell, Alistair Wardrope, Rajiv Mohanraj, Anthony Guy Marson, Markus Reuber   +11 more
wiley   +1 more source

Evaluation of the Potential of Novel Co-Processed Excipients to Enable Direct Compression and Modified Release of Ibuprofen. [PDF]

Pharmaceutics
Aleksić I, Glišić T, Ćirin-Varađan S, Djuris M, Djuris J, Parojčić J.   +5 more
europepmc   +1 more source

Real world testing and cost‐effectiveness analysis of subcutaneous EEG (REAL‐ASE): Protocol for a prospective multicentre interventional trial

Epilepsia Open, EarlyView.
Abstract Objective Epilepsy is a common condition associated with significant morbidity, mortality, and costs. Poor documentation of seizures is a major challenge in epilepsy care. Objective seizure counting with mobile devices may mitigate this challenge and improve patient management.
Matthew McWilliam, Pedro F. Viana, Eren Dursun, Joe Davies, Joel S. Winston, Jessica Agren, Harutomo Hasegawa, Jonas Duun‐Henriksen, Mark P. Richardson   +8 more
wiley   +1 more source