Results 141 to 150 of about 30,492 (316)

Listerin Alleviates Alzheimer's Disease through IRE1‐mediated Decay of TLR4 mRNA

Advanced Science, EarlyView.
Alzheimer's disease (AD) progression is influenced by microglia‐mediated neuroinflammation. Here, it is demonstrated that Listerin suppresses neuroinflammatory signaling and cognitive impairment in AD models by triggering IRE1α‐mediated TLR4 mRNA decay. Adenoviral Listerin delivery reduces amyloid‐β pathology, positioning it as a new therapeutic target.
Fei Qin, Runyu Cao, Xuemei Bai, Jiahua Yuan, Wanwei Sun, Yi Zheng, Xiaopeng Qi, Wei Zhao, Bingyu Liu, Chengjiang Gao   +9 more
wiley   +1 more source

Effect of scientific principles of gavage feeding in oral medicine administration on knowledge and function of nurses in intensive care unit (ICU) [PDF]

, 2016
Medication through an enteral feeding tube is one of the main cares in patients hospitalized in the intensive care unit continuously being a challenge. Correct delivery of medication through an enteral feeding tube requires specific knowledge and skills ...
Ghahfarrokhi, S.S., Hekmatpou, D., Khoddami, M., Rouhi-Boroujeni, H.   +3 more
core  

Comparison Studies Of Enteric Coated And Uncoated Tablets

Aspirin is belonging to the class of NSAID having analgesic, antipyretic, anti-inflammatory and antiplatelet activity at regular normal doses. At higher doses it causes gastrointestinal ulcers, stomach bleeding etc. This effect of aspirin can be minimized by preventing the drug exposure to the gastric region which is achieved by using enteric coating ...
openaire   +1 more source

Activation of Kir4.1 Channels by 2‐D08 Promotes Myelin Repair in Multiple Sclerosis

Advanced Science, EarlyView.
Multiple sclerosis causes myelin loss and neurological dysfunction. This study shows that 2‐D08, a small molecule targeting Kir4.1 channels, promotes OPCs differentiation via FYN tyrosine kinase phosphorylation and the FYN/MYRF pathway. It significantly improves myelin repair and motor deficits in EAE mice and marmosets, highlighting its potential as a
Mingdong Liu, Shengyu Jin, Xin Fu, Chong Xie, Yi Chen, Liangtang Chang, Yongheng Fan, Donghua He, Xiaoqi Hong, Xi Shen, Xiaoli Zheng, Qiyue Wang, Dao Shi, Fangyuan Li, Daishun Ling, Yangtai Guan, Neng Gong, Xiaoping Tong   +17 more
wiley   +1 more source

Mercaptophenylboronic Acid‐Mediated Nanozyme Immunochromatographic Assay for Simultaneous Detection of Respiratory Bacteria and Virus

Advanced Science, EarlyView.
This study developes a universal colorimetric ICA platform that integrates broad‐spectrum recognition by 4‐mercaptophenylboronic acid with dual signal enhancement—both colorimetric and catalytic—mediated by a biomimetic magnetic nanozyme. This platform, for the first time, enables simple, convenient, ultrasensitive, and simultaneous screening of ...
Qing Yu, Jiaxuan Li, Shuai Zheng, Yajin Hu, Benshun Tian, Meirou Lu, Bing Gu, Chongwen Wang   +7 more
wiley   +1 more source

Effect of disintegrants on the properties of multiparticulate tablets comprising starch pellets and excipient granules [PDF]

, 2012
De Beer, Thomas, Mehta, Samata, Remon, Jean Paul, Vervaet, Chris   +3 more
core   +1 more source

Pyloric stenosis: Hold-up of enteric coated aspirin tablets

Journal of British Surgery, 1973
Abstract The case is presented of a 68-year-old woman with adult hypertrophic pyloric stenosis who ingested 66 enteric coated 650-mg. aspirin tablets over the course of 11 days immediately prior to her admission to hospital. Most of these tablets remained intact in the hugely dilated obstructed stomach and were recovered at emergency ...
openaire   +3 more sources

Mechanical Stress Induced NOX2 Promotes Endothelial Dysfunction in Ventilator‐Induced Lung Injury: Potential Treatment with Quercetin

Advanced Science, EarlyView.
Abnormal mechanical stretch induced by mechanical ventilation (MV) disrupts endothelial junctions via the NOX2/ROS/CaMKII/ERK1/2 axis both in human aortic endothelial cells (HAECs) in vitro and in ventilator‐induced lung injury (VILI) in mice. Quercetin, an antioxidant predicted to bind to NOX2, can effectively prevent mechanical stretch‐induced ...
Tao Jiang, Yabing Zhang, Zhiye Guo, He Ren, Weiyi Hu, Qingping Yao, Yunlong Huo, Yingxin Qi, Kai Huang   +8 more
wiley   +1 more source

Fast pH‐Driven Solubilization Method of Realgar (As4S4) to Reduce the Toxicity of Arsenic [As(III)] for Medicinal Purposes

Advanced Science, EarlyView.
Arsenic trioxide transformed acute promyelocytic leukemia therapy and shows promise against HIV. A new method to solubilize the mineral realgar produces different arsenic species depleting the main arsenic target, nuclear PML protein, and retaining effects on leukemic and HIV reservoir cells, while minimizing off‐target damage.
Bojana Lucic, Douglas Santana Franciscato, Helton Pereira Nogueira, Lara Gallucci, Alceu Totti Silveira Junior, Asmaa Mohamed Ismail, Millie Robinson, Teresa Dallinger, Claudia Gutfleisch, Jochen Kurz, Maytê Toledo, Jessica Dias da Silva Ferraz, Mohammad Tarek, Danilo Dias, Ricardo Sobhie Diaz, Mahmoud ElHefnawi, Mattia Forcato, Hugo P Monteiro, Marina Lusic, Iart Luca Shytaj, Andrea Savarino   +20 more
wiley   +1 more source

Color‐Filter‐Free Image Sensor Using CsPbBr3 Quantum‐Dot‐Based Tamm Plasmon Photodetector for Photonic Synapse Facial Recognition

Advanced Science, EarlyView.
A cutting‐edge color‐filter‐free photodetector that seamlessly integrates a monolayer perovskite quantum dots absorber by leveraging Tamm plasmon resonance enhances optical absorption through strong light–matter coupling and demonstrates synaptic‐like dynamics, enabling neuron‐inspired facial recognition.
Meng‐Cheng Yen, Yung‐Chi Yao, Chia‐Jung Lee, Shi‐Hui Huang, Wei Jie Hong, Yuto Kajino, Hsu‐Cheng Hsu, Min‐Hsiung Shih, Gong‐Ru Lin, Kaoru Tamada, Jinn‐Kong Sheu, Ya‐Ju Lee   +11 more
wiley   +1 more source