Results 81 to 90 of about 817 (222)

Insights on Advances in 3D Bioprinting for Peripheral Nerve Regeneration

Advanced Therapeutics, EarlyView.
Peripheral nerve injury is a common condition due to trauma that significantly impacts the life of the affected individual. This review explores the anatomy, classification, and pathophysiology of peripheral nerve injuries. It also discusses various types of nerve conduits and presents a detailed review of 3D bioprinted nerve conduits used in both in ...
Nasera Rizwana, Samartha M C, Ashwath Acharya, Goutam Thakur, Manasa Nune, Vipul Agarwal   +5 more
wiley   +1 more source

Modulation of mesalamine release from enteric-coated matrix tablets using natural polysaccharides for localized colonic delivery

Journal of Applied Pharmaceutical Research
Background: Inflammatory bowel diseases (IBD) require effective colon-targeted drug delivery for improved therapeutic efficacy and minimized systemic side effects.
Shilpa Sahu, Prasanta Kumar Choudhury, Gourishyam Pasa, Padala Narasimha Murthy, Poonam Sahu, Renuka Verma   +5 more
doaj   +1 more source

Development and evaluation of microporous osmotic tablets of diltiazem hydrochloride

Journal of Advanced Pharmaceutical Technology & Research, 2012
Microporous osmotic tablet of diltiazem hydrochloride was developed for colon targeting. These prepared microporous osmotic pump tablet did not require laser drilling to deliver the drug to the specific site of action.
Afifa Bathool, D V Gowda, Mohammed S Khan, Ayaz Ahmed, S L Vasudha, K Rohitash   +5 more
doaj   +1 more source

Swallowing a cellular automaton pill: predicting drug release from a matrix tablet [PDF]

Simulation, 90:227-237 (2014), 2012
Matrix tablets are drug delivery devices designed to release a drug in a controlled manner over an extended period of time. We develop a cellular automaton (CA) model for the dissolution and release of a water-soluble drug and excipient from a matrix tablet of water-insoluble polymer.
arxiv  

Functional Polarization of Liver Macrophages by Glyco Gold Nanoparticles

Advanced Science, EarlyView.
Macrophages play a critical role in several pathophysiological diseases by being involved in the activation of adaptive and innate immune responses. The repolarization of macrophages using gold nanoparticles functionalized with glycans for a more selective targeting toward a restorative phenotype leads to an amelioration of the events.
Jennifer Fernandez Alarcon, Patricia Perez Schmidt, Nicolo Panini, Francesca Caruso, Martina B. Violatto, Naths Grazia Sukubo, Alberto Martinez‐Serra, Charlotte Blanche Ekalle‐Soppo, Annalisa Morelli, Giulia Yuri Moscatiello, Chiara Grasselli, Alessandro Corbelli, Fabio Fiordaliso, Joe Kelk, Laura Petrosilli, Giuseppe d'Orazio, Ruth Mateu Ferrando, Ariadna Verdaguer Ferrer, Cristina Fornaguera, Luigi Lay, Stefano Fumagalli, Sandro Recchia, Marco P. Monopoli, Laura Polito, Paolo Bigini, Giovanni Sitia   +25 more
wiley   +1 more source

PCSK9 Promotes the Malignancy of Triple‐negative Breast Cancer Cells by Reducing Cholesterol Levels at the Plasma Membrane to Activate EGFR and HER3

Advanced Science, EarlyView.
By decreasing cholesterol and lipid raft levels in the plasma membrane, proprotein convertase subtilisin/kexin type 9 (PCSK9) boosts human epidermal growth factor receptor 1 and 3 (EGFR and HER3) activation, driving tumor growth and metastasis in triple‐negative breast cancer (TNBC).
Tianhong Li, Renfei Wu, Kathy Qian Luo
wiley   +1 more source

A comparative study on corrosion failure analysis of hearing aid devices from different markets

Materials and Corrosion, Volume 74, Issue 1, Page 159-173, January 2023., 2023
The miniaturized design trend in hearing aids has caused a tremendous reduction in sizes for electronic parts and assembly, and as a result, the robustness of the device towards corrosion‐induced failures is compromised. In this study, a large number of field‐failed hearing aid devices across different markets were analyzed to understand their failure ...
Abhijeet Yadav, Rajan Ambat
wiley   +1 more source

Case report: Alectinib-associated intestinal ulceration and colitis in a patient with non-small cell lung cancer and effective treatment with Mesalazine

Pathology and Oncology Research
BackgroundAlectinib is effective in extending the survival of patients with anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC) and generally has manageable side effects.
Zijian Qiu, Fei Ke, Xiaoping Zhu
doaj   +1 more source

Nanotherapy for Neural Retinal Regeneration

Advanced Science, EarlyView.
Nanotechnology enhances ophthalmic treatments by improving drug delivery and regenerating ocular tissues, combating vision loss from retinal diseases through innovative nano‐systems. This review outlines ocular anatomy, pathology, immune microenvironment, and barriers, detailing nanocarrier characteristics, classification, and preparation methods, and ...
Chuyao Yu, Li Dong, Yujia Lv, Xuhan Shi, Ruiheng Zhang, Wenda Zhou, Haotian Wu, Heyan Li, Yitong Li, Zhou Li, Dan Luo, Wen‐Bin Wei   +11 more
wiley   +1 more source

Increased Drug‐Loading Enhances the Activity of Ellipticine in Poly(N‐(2‐hydroxypropyl) Methacrylamide) PHPMA‐Based Polymeric Micelles in 2D and 3D Cancer Cell Models

Macromolecular Chemistry and Physics, Volume 224, Issue 1, January 2023., 2023
This study investigates the cellular uptake and penetration of polymeric micelles with different drug loading contents in 2D and 3D cancer cell models. The higher toxicity in micelles with higher drug loading content is associated with higher cellular uptake in both monolayer cell culture and multicellular tumor spheroids, monitored using confocal ...
Russul Mamdooh Al‐Nakashli, Cheng Cao, Radhika Raveendran, Hongxu Lu, Martina H. Stenzel   +4 more
wiley   +1 more source