Results 31 to 40 of about 205,619 (262)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The application of povidone in the preparation of modified release tablets
Current Issues in Pharmacy and Medical Sciences, 2016 The aim of the study was to investigate the modified release of a model substance, of tablets containing different types of Kollidon and particular additives.
Kasperek Regina +5 more
doaj +1 more source
Improving Learning Outcomes: The iPad and Preschool Children with Disabilities
Frontiers in Psychology, 2017 The digital age has reached early childhood, and the use of touch screens by young children is common place. Research on the use of touch screen tablets with young children is becoming more prevalent; however, less information is available on the use of ...
Linda Chmiliar
doaj +1 more source
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2023 The aim of the work is to develop the industrial technology of tablets with cardioprotective action based on the domestic raw material of cultivated parsnip herb thick extract (CPHTE). Materials and methods.
N. А. Symonenko +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells
FEBS Open Bio, EarlyView.Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
Tecnología, Ciencia y Educación, 2021 Esta propuesta de investigación tiene como principal objetivo profundizar en la repercusión que tiene el uso de las tablets como herramienta en el aprendizaje del alumnado desde la perspectiva docente y familiar del centro concertado Vivaldi.
Lara Alcántara González +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
Niniveh and Alexandria: The Two Vanished Libraries of Antiquity
Revista Română de Biblioteconomie și Știința Informării, 2017 Humankind has dramatically evolved for the past thousands of years in terms of communication - starting from signs and signals conveyed via visual and auditory means and ending up with the set of signs that came to be known as the alphabet over a vast ...
Mariana Borcoman
doaj +1 more source