Results 71 to 80 of about 509,994 (339)

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise

FEBS Open Bio, EarlyView.
Frailty syndrome exacerbates skeletal muscle degeneration via increased ECM deposition and myofiber loss. This study, using a murine model, demonstrates that endurance exercise attenuates these histopathological alterations, preserving muscle integrity. Findings support exercise as a viable strategy to counteract frailty‐induced musculoskeletal decline
Fujue Ji, Hae Sung Lee, Haesung Lee, Jong‐Hee Kim   +3 more
wiley   +1 more source

Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies

FEBS Open Bio, EarlyView.
Carbonic anhydrase IX (CAIX) is a well‐recognised therapeutic target and prognostic biomarker in cancer. We developed and characterised a robust murine breast cancer model system that is suitable for CAIX studies in vitro and in vivo—it comprises both CAIX‐positive and CAIX‐negative controls and provides a solid platform for the comprehensive ...
Zane Kalniņa, Ilva Liekniņa, Svetlana Koteloviča, Ramona Petrovska, Gediminas Žvinys, Agne Petrosiute, Asta Zubrienė, Matīss Toms Laugalis, Vendija Skeltona, Juris Jansons, Madara Kreishmane, Edita Čapkauskaitė, Daumantas Matulis, Kaspars Tārs   +13 more
wiley   +1 more source

Disaggregation of compressed tablets [PDF]

Journal of Pharmacy and Pharmacology, 1974
Tablets of dibasic calcium phosphate containing varying proportions of intra- to extragranular maize starch were prepared at three compaction pressures. The surface area generated per tablet after 10 and 30 min of disintegration was measured with an automated counter by a new technique.
Michael H. Rubinstein, Dorothy M. Bodey
openaire   +3 more sources

Open‐source deep‐learning models for segmentation of normal structures for prostatic and gynecological high‐dose‐rate brachytherapy: Comparison of architectures

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Background The use of deep learning‐based auto‐contouring algorithms in various treatment planning services is increasingly common. There is a notable deficit of commercially or publicly available models trained on large or diverse datasets containing high‐dose‐rate (HDR) brachytherapy treatment scans, leading to poor performance on images ...
Andrew J. Krupien, Yasin Abdulkadir, Dishane C. Luximon, John Charters, Huiming Dong, Jonathan Pham, Dylan O'Connell, Jack Neylon, James M. Lamb   +8 more
wiley   +1 more source

Novel CT radiomics models for the postoperative prediction of early recurrence of resectable pancreatic adenocarcinoma: A single‐center retrospective study in China

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose To assess the predictive capability of CT radiomics features for early recurrence (ER) of pancreatic ductal adenocarcinoma (PDAC). Methods Postoperative PDAC patients were retrospectively selected, all of whom had undergone preoperative CT imaging and surgery. Both patients with resectable or borderline‐resectable pancreatic cancer met
Xinze Du, Yongsu Ma, Kexin Wang, Xiejian Zhong, Jianxin Wang, Xiaodong Tian, Xiaoying Wang, Yinmo Yang   +7 more
wiley   +1 more source

Tablet Splitting: Influence of Technique and Tablet Format

, 2022
Tablet splitting is a commonly used technique to obtain half of the dose or to facilitate tablet intake. However, there is a risk of not obtaining the correct dose and the efficacy depends on factors such as splitting method and tablet characteristics.
Alexandre, Ana, Ferreira, Sónia, Jesus, Ângelo   +2 more
openaire   +2 more sources

Compressibility of tableting materials and properties of tablets with glyceryl behenate [PDF]

Acta Pharmaceutica, 2015
Abstract The paper studies the compressibility of directly compressible tableting materials with dry binders, spray-dried lactose and microcrystalline cellulose, and glyceryl dibehenate at various concentrations. Compressibility was evaluated by means of the energy profile of compression and tensile strength of tablets.
Jitka Mužíková, Václav Lochař, Alena Komersová, Sandra Muchová   +3 more
openaire   +4 more sources

Unsupervised non‐small cell lung cancer tumor segmentation using cycled generative adversarial network with similarity‐based discriminator

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Background Tumor segmentation is crucial for lung disease diagnosis and treatment. Most existing deep learning‐based automatic segmentation methods rely on manually annotated data for network training. Purpose This study aims to develop an unsupervised tumor segmentation network smic‐GAN by using a similarity‐driven generative adversarial ...
Chengyijue Fang, Xiaoyang Li, Yidong Yang   +2 more
wiley   +1 more source

Effects of Formulation and Process Variables on Gastroretentive Floating Tablets with A High-Dose Soluble Drug and Experimental Design Approach

Pharmaceutics, 2018
To develop sustained release gastro-retentive effervescent floating tablets (EFT), a quality-based experimental design approach was utilized during the composing of a hydrophilic matrix loaded with a high amount of a highly water-soluble model drug ...
P. Thapa, S. Jeong
semanticscholar   +1 more source