Results 111 to 120 of about 4,618 (156)

OSA Initiates Histone Lactylation That Drives PDE4B/FUS/AGT Axis to Pulmonary Hypertension

Cell Proliferation, EarlyView.
This study illustrates how chronic intermittent hypoxia (CIH) in obstructive sleep apnea (OSA) leads to hypertension via increased oxidative stress and mitochondrial dysfunction in pulmonary artery smooth muscle cells (PASMCs), causing glycolytic dysregulation. Lactate accumulation enhances histone lactylation, upregulating phosphodiesterase 4B (PDE4B),
Li Yang, Qing Ni, Yan He, Shijie Liu, Lulu Gan, Anni Dai, Yang Hu, Qian Liu, Xueling Yang, Jiqian Li, Yi Tao, Yunyu Li, Mingyue Xu   +12 more
wiley   +1 more source

Comparison of Oral Antidiabetic Medications and Insulin Therapy for Glucocorticoid-Induced Hyperglycemia in Patients with Autoimmune Diseases. [PDF]

J Clin Med
Ueno S, Tajima M, Saito K, Yoshikawa M, Isozaki T, Sato H, Sugiyama E.   +6 more
europepmc   +1 more source

AMSC‐sEVs Ameliorated Crohn's Disease by Inhibiting Macrophage‐Myofibroblast Transition Through the Delivery of MFGE8

Cell Proliferation, EarlyView.
Our study demonstrated that TGF‐β1 activated MAPK signalling pathway and promoted the MMT and secretion of CCL17 under CD‐associated intestinal inflammatory conditions. AMSC‐sEVs can deliver MFGE8, which inhibits MMT and CCL17‐mediated Treg recruitment by suppressing the MAPK signalling pathway, thereby alleviating intestinal fibrosis.
Minghao Xie, Qiang Liu, Zhizhong Xiong, Jian Li, Ruiri Jin, Lei Lian, Zhengrong Li   +6 more
wiley   +1 more source

Guidelines for Enhanced Recovery After Trauma and Intensive Care (ERATIC): Enhanced Recovery After Surgery (ERAS) and International Association for Trauma Surgery and Intensive Care (IATSIC) Society Recommendations: Paper 2: Postoperative and Intensive Care Recommendations. [PDF]

World J Surg
Hardcastle TC, Gaarder C, Balogh Z, D'amours S, Davis KA, Gupta A, Mohseni S, Naess PA, Naidoo S, Razek T, Robertson S, Uchino H, Zonies D, Whing J, Scott MJ.   +14 more
europepmc   +1 more source

Epoxy resin‐based sealers modified with clay nanoparticles: Evaluation of their physicochemical and mechanical properties

European Journal of Oral Sciences, EarlyView.
Abstract Epoxy resin‐based sealers are commonly used in endodontic treatment due to their superior physicochemical properties. Therefore, it is important to utilize these materials by enhancing their properties. Nonetheless, several of their properties remain suboptimal, including the relatively prolonged setting time, the moderate yet clinically ...
Fotis Dimopoulos, Konstantinos Kodonas, Alexandros K. Nikolaidis, Elisabeth A. Koulaouzidou, Nikolaos Economides, Christos Gogos   +5 more
wiley   +1 more source

Systematic analysis of COVID-19 mRNA vaccines using four orthogonal approaches demonstrates no excessive DNA impurities. [PDF]

NPJ Vaccines
Achs A, Sedlackova T, Predajna L, Budis J, Bartosova M, Zelnik V, Rusnakova D, Melichercikova M, Miklosova M, Gencurova V, Cernakova B, Szemes T, Klempa B, Kopacek J, Pastorekova S.   +14 more
europepmc   +1 more source

Successful use of haemoperfusion therapy in an adult horse with hepatic encephalopathy and cholangiohepatitis

Equine Veterinary Education, EarlyView.
Summary A 4‐year‐old, 520 kg, American Quarter Horse broodmare, approximately 90 days in foal, was presented to Texas A&M University Teaching Hospital for suspected liver disease. Based on clinicopathological values and hepatic abnormalities noted ultrasonographically, the mare was presumptively diagnosed with cholangiohepatitis.
A. C. Trimble, S. H. White‐Springer, S. Alpini, E. Rumfola, A. N. DiSilvestro, Y. Ueda, K. Hobbs   +6 more
wiley   +1 more source

Reactive Oxygen Species in Embryo Development: Sources, Impacts, and Implications for In Vitro Culture Systems. [PDF]

Life (Basel)
Sunuwar S, Heo YS.
europepmc   +1 more source

Update on diagnosis, nonpharmacological treatment and prevention of Equine Gastric Ulcer Syndrome (EGUS)

Equine Veterinary Education, EarlyView.
Summary The term Equine Gastric Ulcer Syndrome (EGUS) has been used since 1999. As there are important differences, the terms Equine Squamous Gastric Disease (ESGD) and Equine Glandular Gastric Disease (EGGD) were introduced in 2015. Risk factors like dietary management, training regimens and drug side effects, as described for NSAIDs, predispose ...
R. Lensing, A. K. Barton
wiley   +1 more source