Results 71 to 80 of about 3,856 (257)

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Simulation of Knowledge Transfer Process Model Between Universities: A Perspective of Cluster Innovation Network

Complexity, 2018
Combined with the basic properties of the cluster innovation network, with the cluster innovation network, which can be composed of different universities that have knowledge potential difference as the research object, the knowledge transfer process is ...
Fang Wei, Xiao Limin
doaj   +1 more source

Establishing Tacit Knowledge Capture System in Project-Oriented Organizations Based on TOGAF Enterprise Architecture: A Systematic Review [PDF]

کتابداری و اطلاع‌رسانی
Objective: This study seeks to investigate how to establish a tacit knowledge capture system in project-oriented organizations based on TOGAF enterprise architecture. Methodology: Due to few research studies on how to implement enterprise architecture in
Mandana Hayati, Saeideh Ebrahimi, Alireza Nikseresht, Mahmood Javan, Zouhayr Hayati   +4 more
doaj   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

R&D outsourcing contract for the unverified value of tacit knowledge sharing

Journal of Industrial Engineering and Management, 2015
Purpose: The purpose of this paper is to provide a R&D outsourcing contract design framework to incent R&D outsourcing service providers sharing tacit and explicit knowledge. Design/methodology/approach: The author uses the principal-agent theory
Han Song, YuQing Liu, Ying Dai, Jing Zhu
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

International spillovers, knowledge acquisition and transfer among Japanese firms in the United States

Journal of Business Economics and Management, 2013
In this paper, we investigate (i) the relationship between international spillovers and knowledge acquisition, and, (ii) intra-firm subsidiary-to-parent transfer of technology among Japanese firms in the United States. Using a survey of 185 firms, probit
Qingyan Shang, Jessie P. H. Poon
doaj   +1 more source

Tacit Knowledge Transfer: Information Technology Usage in Universities

Proceedings of the 11th International Joint Conference on Knowledge Discovery, Knowledge Engineering and Knowledge Management, 2019
The importance of transferring tacit knowledge transfer is acknowledged in the literature, but the usage of information technology for tacit knowledge transfer is not well researched. Through a mixed methods approach, employing an online questionnaire and interviews, this study explored the perceptions of university academic staff with regards to ...
openaire   +1 more source