Results 1 to 10 of about 11,887 (115)

Personalized tacrolimus therapy in allogeneic hematopoietic stem cell transplantation: from pharmacokinetic variability to novel control strategies [PDF]

Journal of Pharmaceutical Health Care and Sciences
Background Allogeneic hematopoietic stem cell transplantation is an established curative therapy for many hematological diseases, but graft-versus-host disease remains a major cause of morbidity and mortality.
Naoki Yoshikawa
doaj   +2 more sources

Total and Free Blood and Plasma Concentration Changes in Pregnancy for Medicines Highly Bound to Plasma Proteins: Application of Physiologically Based Pharmacokinetic Modelling to Understand the Impact on Efficacy

Pharmaceutics, 2023
Free drug concentrations are generally considered the pharmacologically active moiety and are important for cellular diffusion and distribution. Pregnancy-related changes in plasma protein binding and blood partitioning are due to decreases in plasma ...
Paola Coppola, Andrew Butler, Susan Cole, Essam Kerwash   +3 more
doaj   +1 more source

A multi-omics investigation of tacrolimus off-target effects on a proximal tubule cell-line

Pharmacological Research, 2023
Introduction: Tacrolimus, an immunosuppressive drug prescribed to a majority of organ transplant recipients is nephrotoxic, through still unclear mechanisms.
Hassan Aouad, Quentin Faucher, François-Ludovic Sauvage, Emilie Pinault, Claire-Cécile Barrot, Hélène Arnion, Marie Essig, Pierre Marquet   +7 more
doaj   +1 more source

Assessing Trans-Inhibition of OATP1B1 and OATP1B3 by Calcineurin and/or PPIase Inhibitors and Global Identification of OATP1B1/3-Associated Proteins

Pharmaceutics, 2023
Organic anion transporting polypeptide (OATP) 1B1 and OATP1B3 are key determinants of drug–drug interactions (DDIs). Various drugs including the calcineurin inhibitor (CNI) cyclosporine A (CsA) exert preincubation-induced trans-inhibitory effects upon ...
John T. Powell, Ruhul Kayesh, Alexandra Ballesteros-Perez, Khondoker Alam, Pascaline Niyonshuti, Erik J. Soderblom, Kai Ding, Chao Xu, Wei Yue   +8 more
doaj   +1 more source

ABCB1 1199G>A genetic polymorphism (Rs2229109) influences the intracellular accumulation of tacrolimus in HEK293 and K562 recombinant cell lines. [PDF]

PLoS ONE, 2014
ATP-binding cassette, subfamily B, member 1 (ABCB1) transporter, or P-glycoprotein, is an efflux protein implicated in the absorption and the distribution of various compounds, including tacrolimus and cyclosporine A.
Géraldine Dessilly, Laure Elens, Nadtha Panin, Arnaud Capron, Anabelle Decottignies, Jean-Baptiste Demoulin, Vincent Haufroid   +6 more
doaj   +1 more source

Characterization of the FKBP12-Encoding Genes in Aspergillus fumigatus. [PDF]

PLoS ONE, 2015
Invasive aspergillosis, largely caused by Aspergillus fumigatus, is responsible for a growing number of deaths among immunosuppressed patients. Immunosuppressants such as FK506 (tacrolimus) that target calcineurin have shown promise for antifungal drug ...
Katie Falloon, Praveen R Juvvadi, Amber D Richards, José M Vargas-Muñiz, Hilary Renshaw, William J Steinbach   +5 more
doaj   +1 more source

Evolución clínica en un receptor de trasplante de hígado con la COVID-19: ¿Un efecto benéfico del tacrolimus?

Revista de Gastroenterología de México, 2020
Resumen: La enfermedad por coronavirus 2019 (COVID-19) es una enfermedad respiratoria seria causada por el virus SARS-CoV-2. Existe controversia respecto a si los inmunosupresores representan un factor de riesgo para desarrollar una enfermedad más grave ...
I. García-Juárez, A. Campos-Murguía, V.H. Tovar-Méndez, A. Gabutti, I. Ruiz   +4 more
doaj   +1 more source

Computational identification of host genomic biomarkers highlighting their functions, pathways and regulators that influence SARS-CoV-2 infections and drug repurposing

Scientific Reports, 2022
The pandemic threat of COVID-19 has severely destroyed human life as well as the economy around the world. Although, the vaccination has reduced the outspread, but people are still suffering due to the unstable RNA sequence patterns of SARS-CoV-2 which ...
Md. Parvez Mosharaf, Md. Selim Reza, Md. Kaderi Kibria, Fee Faysal Ahmed, Md. Hadiul Kabir, Sohel Hasan, Md. Nurul Haque Mollah   +6 more
doaj   +1 more source

Identification of host transcriptome-guided repurposable drugs for SARS-CoV-1 infections and their validation with SARS-CoV-2 infections by using the integrated bioinformatics approaches.

PLoS ONE, 2022
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is one of the most severe global pandemic due to its high pathogenicity and death rate starting from the end of 2019.
Fee Faysal Ahmed, Md Selim Reza, Md Shahin Sarker, Md Samiul Islam, Md Parvez Mosharaf, Sohel Hasan, Md Nurul Haque Mollah   +6 more
doaj   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source