Results 11 to 20 of about 11,864 (126)

Evolución clínica en un receptor de trasplante de hígado con la COVID-19: ¿Un efecto benéfico del tacrolimus?

Revista de Gastroenterología de México, 2020
Resumen: La enfermedad por coronavirus 2019 (COVID-19) es una enfermedad respiratoria seria causada por el virus SARS-CoV-2. Existe controversia respecto a si los inmunosupresores representan un factor de riesgo para desarrollar una enfermedad más grave ...
I. García-Juárez, A. Campos-Murguía, V.H. Tovar-Méndez, A. Gabutti, I. Ruiz   +4 more
doaj   +1 more source

Computational identification of host genomic biomarkers highlighting their functions, pathways and regulators that influence SARS-CoV-2 infections and drug repurposing

Scientific Reports, 2022
The pandemic threat of COVID-19 has severely destroyed human life as well as the economy around the world. Although, the vaccination has reduced the outspread, but people are still suffering due to the unstable RNA sequence patterns of SARS-CoV-2 which ...
Md. Parvez Mosharaf, Md. Selim Reza, Md. Kaderi Kibria, Fee Faysal Ahmed, Md. Hadiul Kabir, Sohel Hasan, Md. Nurul Haque Mollah   +6 more
doaj   +1 more source

P-glycoprotein, FK-binding Protein-12, and the Intracellular Tacrolimus Concentration in T-lymphocytes and Monocytes of Kidney Transplant Recipients

Transplantation, 2022
Background . Transplant recipients may develop rejection despite having adequate tacrolimus whole blood predose concentrations (C0). The intra-immune cellular concentration is potentially a better target than C0. However, little is known regarding intracellular tacrolimus concentration in T-lymphocytes and monocytes.
Udomkarnjananun, Suwasin, Francke, Marith I., Dieterich, Marjolein, Van De Velde, Daan, Litjens, Nicolle H.R., Boer, Karin, De Winter, Brenda C.M., Baan, Carla C., Hesselink, Dennis A.   +8 more
openaire   +2 more sources

Identification of host transcriptome-guided repurposable drugs for SARS-CoV-1 infections and their validation with SARS-CoV-2 infections by using the integrated bioinformatics approaches.

PLoS ONE, 2022
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is one of the most severe global pandemic due to its high pathogenicity and death rate starting from the end of 2019.
Fee Faysal Ahmed, Md Selim Reza, Md Shahin Sarker, Md Samiul Islam, Md Parvez Mosharaf, Sohel Hasan, Md Nurul Haque Mollah   +6 more
doaj   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

Tacrolimus Pharmacokinetic and Pharmacogenomic Differences between Adults and Pediatric Solid Organ Transplant Recipients

Pharmaceutics, 2010
Tacrolimus is a calcineurin inhibitor immunosuppressant that has seen considerable use in both adult and pediatric solid organ transplant recipients.
Amy Lu, Jerry Altshuler, Kwaku Marfo
doaj   +1 more source

Effect of genetic polymorphism on individualized treatment of tacrolimus in patients with primary nephrotic syndrome

Linchuang shenzangbing zazhi, 2021
As a highly effective immunosuppressant, tacrolimus（TAC,FK506）has been widely applied for primary nephrotic syndrome.However, excessive dose or underexposure of TAC remains rampant in clinical practices.Recent studies have indicated that cytochrome P450 ...
Xiong Lian-lian, Yi Bin
doaj  

Effects of Destruxin A on Silkworm’s Immunophilins

Toxins, 2019
Destruxin A (DA), a major secondary metabolite of Metarhizium anisopliae, has anti-immunity to insects. However, the detailed mechanism and its interactions with target proteins are elusive.
Jingjing Wang, Qunfang Weng, Qiongbo Hu
doaj   +1 more source

Action of tacrolimus on Wistar rat kidneys implanted with Walker 256 carcinosarcoma Estudo da ação do tacrolimus em rins de ratos Wistar implantados com carcinossarcoma de Walker

Acta Cirúrgica Brasileira, 2010
PURPOSE: To evaluate the development of Walker 256 tumor in male Wistar rats treated with tacrolimus using an experimental kidney tumor model. METHODS: 40 male Wistar rats were divided into four groups: Tumor group (TU) (n=10), Tacrolimus-Tumor group (TT)
Cristiano Machado Inácio, Ulrich Andréas Dietz, Osvaldo Malafaia, Jurandir Marcondes Ribas Filho, Paulo Afonso Nunes Nassif, Nicolau Gregori Czeczko, Carmen Australia Paredes Marcondes   +6 more
doaj   +1 more source

Tacrolimus (FK506) prevents early stages of ethanol induced hepatic fibrosis by targeting LARP6 dependent mechanism of collagen synthesis.

PLoS ONE, 2013
Tacrolimus (FK506) is a widely used immunosuppressive drug. Its effects on hepatic fibrosis have been controversial and attributed to immunosuppression.
Zarko Manojlovic, John Blackmon, Branko Stefanovic   +2 more
doaj   +1 more source