Results 11 to 20 of about 11,965 (161)

Tacrolimus Pharmacokinetic and Pharmacogenomic Differences between Adults and Pediatric Solid Organ Transplant Recipients

Pharmaceutics, 2010
Tacrolimus is a calcineurin inhibitor immunosuppressant that has seen considerable use in both adult and pediatric solid organ transplant recipients.
Amy Lu, Jerry Altshuler, Kwaku Marfo
doaj   +2 more sources

Identification of tacrolimus-related genes in familial combined hyperlipidemia and development of a diagnostic model using bioinformatics analysis

Heliyon
Background: Clinical observations have revealed that patients undergoing organ transplantation administered tacrolimus often experience abnormal lipid metabolism with serious consequences.
Yuan Xu, Hongfei He, Haiyang Li
doaj   +2 more sources

Tacrolimus (FK506) prevents early stages of ethanol induced hepatic fibrosis by targeting LARP6 dependent mechanism of collagen synthesis.

PLoS ONE, 2013
Tacrolimus (FK506) is a widely used immunosuppressive drug. Its effects on hepatic fibrosis have been controversial and attributed to immunosuppression.
Zarko Manojlovic, John Blackmon, Branko Stefanovic   +2 more
doaj   +2 more sources

Effects of Destruxin A on Silkworm’s Immunophilins

Toxins, 2019
Destruxin A (DA), a major secondary metabolite of Metarhizium anisopliae, has anti-immunity to insects. However, the detailed mechanism and its interactions with target proteins are elusive.
Jingjing Wang, Qunfang Weng, Qiongbo Hu
doaj   +2 more sources

Evolución clínica en un receptor de trasplante de hígado con la COVID-19: ¿Un efecto benéfico del tacrolimus?

Revista de Gastroenterología de México, 2020
Resumen: La enfermedad por coronavirus 2019 (COVID-19) es una enfermedad respiratoria seria causada por el virus SARS-CoV-2. Existe controversia respecto a si los inmunosupresores representan un factor de riesgo para desarrollar una enfermedad más grave ...
I. García-Juárez, A. Campos-Murguía, V.H. Tovar-Méndez, A. Gabutti, I. Ruiz   +4 more
doaj   +1 more source

Computational identification of host genomic biomarkers highlighting their functions, pathways and regulators that influence SARS-CoV-2 infections and drug repurposing

Scientific Reports, 2022
The pandemic threat of COVID-19 has severely destroyed human life as well as the economy around the world. Although, the vaccination has reduced the outspread, but people are still suffering due to the unstable RNA sequence patterns of SARS-CoV-2 which ...
Md. Parvez Mosharaf, Md. Selim Reza, Md. Kaderi Kibria, Fee Faysal Ahmed, Md. Hadiul Kabir, Sohel Hasan, Md. Nurul Haque Mollah   +6 more
doaj   +1 more source

P-glycoprotein, FK-binding Protein-12, and the Intracellular Tacrolimus Concentration in T-lymphocytes and Monocytes of Kidney Transplant Recipients

Transplantation, 2022
Background . Transplant recipients may develop rejection despite having adequate tacrolimus whole blood predose concentrations (C0). The intra-immune cellular concentration is potentially a better target than C0. However, little is known regarding intracellular tacrolimus concentration in T-lymphocytes and monocytes.
Udomkarnjananun, Suwasin, Francke, Marith I., Dieterich, Marjolein, Van De Velde, Daan, Litjens, Nicolle H.R., Boer, Karin, De Winter, Brenda C.M., Baan, Carla C., Hesselink, Dennis A.   +8 more
openaire   +2 more sources

Identification of host transcriptome-guided repurposable drugs for SARS-CoV-1 infections and their validation with SARS-CoV-2 infections by using the integrated bioinformatics approaches.

PLoS ONE, 2022
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is one of the most severe global pandemic due to its high pathogenicity and death rate starting from the end of 2019.
Fee Faysal Ahmed, Md Selim Reza, Md Shahin Sarker, Md Samiul Islam, Md Parvez Mosharaf, Sohel Hasan, Md Nurul Haque Mollah   +6 more
doaj   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

Screening of a HUVEC cDNA library with transplant-associated coronary artery disease sera identifies RPL7 as a candidate autoantigen associated with this disease. [PDF]

, 2001
A HUVEC cDNA library was screened with sera from two patients who had developed transplant-associated coronary artery disease (TxCAD) following cardiac transplantation.
Marchant, B., Linke, A.T., Murphy, John J., Linke, A T, Rose, Marlene L., Marchant, B, Rose, M L, Marsh, P, Murphy, J, Marsh, P., Frampton, Geoffrey, Frampton, G   +11 more
core   +1 more source