Results 11 to 20 of about 11,900 (130)

Personalized tacrolimus therapy in allogeneic hematopoietic stem cell transplantation: from pharmacokinetic variability to novel control strategies [PDF]

Journal of Pharmaceutical Health Care and Sciences
Background Allogeneic hematopoietic stem cell transplantation is an established curative therapy for many hematological diseases, but graft-versus-host disease remains a major cause of morbidity and mortality.
Naoki Yoshikawa
doaj   +2 more sources

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges. [PDF]

Neuroprotection
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Manavi MA, Salehi M, Mohammad Jafari R, Goudarzi R, Khosravi S, Dehpour AR.   +5 more
europepmc   +2 more sources

Tacrolimus ameliorates podocyte injury by restoring FK506 binding protein 12 (FKBP12) at actin cytoskeleton [PDF]

The FASEB Journal, 2021
Abstract FKBP12 was identified as a binding protein of tacrolimus (Tac). Tac binds to FKBP12 and exhibits immunosuppressive effects in T cells. Although it is reported that Tac treatment directly ameliorates the dysfunction of the podocyte in nephrotic syndrome, the precise pharmacological mechanism of Tac is not well understood yet ...
Hidenori, Yasuda, Yoshiyasu, Fukusumi, Veniamin, Ivanov, Ying, Zhang, Hiroshi, Kawachi   +4 more
openaire   +2 more sources

Renal Deletion of 12 kDa FK506-Binding Protein Attenuates Tacrolimus-Induced Hypertension [PDF]

Journal of the American Society of Nephrology, 2015
Tacrolimus is a widely used immunosuppressive drug that inhibits the phosphatase calcineurin when bound to the 12 kDa FK506-binding protein (FKBP12). When this binding occurs in T cells, it leads to immunosuppression. Tacrolimus also causes side effects, however, such as hypertension and hyperkalemia.
Rebecca A, Lazelle, Belinda H, McCully, Andrew S, Terker, Nina, Himmerkus, Katharina I, Blankenstein, Kerim, Mutig, Markus, Bleich, Sebastian, Bachmann, Chao-Ling, Yang, David H, Ellison   +9 more
openaire   +2 more sources

P-glycoprotein, FK-binding Protein-12, and the Intracellular Tacrolimus Concentration in T-lymphocytes and Monocytes of Kidney Transplant Recipients

Transplantation, 2022
Background . Transplant recipients may develop rejection despite having adequate tacrolimus whole blood predose concentrations (C0). The intra-immune cellular concentration is potentially a better target than C0. However, little is known regarding intracellular tacrolimus concentration in T-lymphocytes and monocytes.
Udomkarnjananun, Suwasin, Francke, Marith I., Dieterich, Marjolein, Van De Velde, Daan, Litjens, Nicolle H.R., Boer, Karin, De Winter, Brenda C.M., Baan, Carla C., Hesselink, Dennis A.   +8 more
openaire   +2 more sources

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

Effects of Destruxin A on Silkworm’s Immunophilins

Toxins, 2019
Destruxin A (DA), a major secondary metabolite of Metarhizium anisopliae, has anti-immunity to insects. However, the detailed mechanism and its interactions with target proteins are elusive.
Jingjing Wang, Qunfang Weng, Qiongbo Hu
doaj   +1 more source

Action of tacrolimus on Wistar rat kidneys implanted with Walker 256 carcinosarcoma Estudo da ação do tacrolimus em rins de ratos Wistar implantados com carcinossarcoma de Walker

Acta Cirúrgica Brasileira, 2010
PURPOSE: To evaluate the development of Walker 256 tumor in male Wistar rats treated with tacrolimus using an experimental kidney tumor model. METHODS: 40 male Wistar rats were divided into four groups: Tumor group (TU) (n=10), Tacrolimus-Tumor group (TT)
Cristiano Machado Inácio, Ulrich Andréas Dietz, Osvaldo Malafaia, Jurandir Marcondes Ribas Filho, Paulo Afonso Nunes Nassif, Nicolau Gregori Czeczko, Carmen Australia Paredes Marcondes   +6 more
doaj   +1 more source

Conformation‐Selective Binding Domains of Intramolecular Chemically Induced Protein Dimerisation Systems

Angewandte Chemie, EarlyView.
Intramolecular chemically induced dimerisation transforms FK506‐ and cyclosporine A‐responsive protein pairs into high‐affinity pseudo‐allosteric switches. Holo‐selective binders isolated by mRNA display convert these switches into gain‐of‐signal biosensors and ultrasensitive ELISAs, enabling direct quantification of both immunosuppressants in ...
Zhenling Cui, Zhong Guo, Yi Jin Liew, Alessandro T. Caputo, Maria M. Fiorito, Cagla Ergun Ayva, Roxane Mutschler, Mayra Barrios Leguarca, Sophia Newton, Gia Nghi Lam, Robert Speight, Brett McWhinney, Yanulla Essie Georges, Carel Pretorius, Jacobus P.J. Ungerer, Kirill Alexandrov   +15 more
wiley   +2 more sources

Tacrolimus (FK506) prevents early stages of ethanol induced hepatic fibrosis by targeting LARP6 dependent mechanism of collagen synthesis.

PLoS ONE, 2013
Tacrolimus (FK506) is a widely used immunosuppressive drug. Its effects on hepatic fibrosis have been controversial and attributed to immunosuppression.
Zarko Manojlovic, John Blackmon, Branko Stefanovic   +2 more
doaj   +1 more source