Results 21 to 30 of about 11,965 (161)

Effect of genetic polymorphism on individualized treatment of tacrolimus in patients with primary nephrotic syndrome

Linchuang shenzangbing zazhi, 2021
As a highly effective immunosuppressant, tacrolimus（TAC,FK506）has been widely applied for primary nephrotic syndrome.However, excessive dose or underexposure of TAC remains rampant in clinical practices.Recent studies have indicated that cytochrome P450 ...
Xiong Lian-lian, Yi Bin
doaj  

Molecular Pathways Leading to Induction of Cell Death and Anti-Proliferative Properties by Tacrolimus and mTOR Inhibitors in Liver Cancer Cells [PDF]

, 2020
Background/Aims: Orthotopic liver transplantation (OLT) is the recommended treatment for patients at early stages of hepatocarcinoma (HCC) with portal hypertension and/or increased bilirubinemia, but without vascular-associated diseases.
Muntané Relat, Jordi, Álamo Martínez, José María, Cruz Díaz, Jesús de la, Negrete, María, Rodríguez Hernández, María A., González, Raul, Gómez Bravo, Miguel Ángel, Marín Gómez, Luis Miguel, Padillo Ruiz, Francisco Javier, Navarro Villarán, Elena, Contreras, Laura, Cruz Ojeda, Patricia de la, Calvo, Antonio   +12 more
core   +1 more source

Action of tacrolimus on Wistar rat kidneys implanted with Walker 256 carcinosarcoma Estudo da ação do tacrolimus em rins de ratos Wistar implantados com carcinossarcoma de Walker

Acta Cirúrgica Brasileira, 2010
PURPOSE: To evaluate the development of Walker 256 tumor in male Wistar rats treated with tacrolimus using an experimental kidney tumor model. METHODS: 40 male Wistar rats were divided into four groups: Tumor group (TU) (n=10), Tacrolimus-Tumor group (TT)
Cristiano Machado Inácio, Ulrich Andréas Dietz, Osvaldo Malafaia, Jurandir Marcondes Ribas Filho, Paulo Afonso Nunes Nassif, Nicolau Gregori Czeczko, Carmen Australia Paredes Marcondes   +6 more
doaj   +1 more source

Cyclophilin nomenclature problems, or, 'a visit from the sequence police'

Human Genomics, 2004
Why is agreement on one particular name for each gene important? As one genome after another becomes sequenced, it is imperative to consider the complexity of genes, genetic architecture, gene expression, gene-gene and gene-product interactions and ...
Nebert Daniel W, Sophos Nickolas A, Vasiliou Vasilis, Nelson David R   +3 more
doaj   +1 more source

FK506 biosynthesis is regulated by two positive regulatory elements in Streptomyces tsukubaensis

BMC Microbiology, 2012
Background FK506 (Tacrolimus) is an important immunosuppressant, produced by industrial biosynthetic processes using various Streptomyces species.
Goranovič Dušan, Blažič Marko, Magdevska Vasilka, Horvat Jaka, Kuščer Enej, Polak Tomaž, Santos-Aberturas Javier, Martínez-Castro Miriam, Barreiro Carlos, Mrak Peter, Kopitar Gregor, Kosec Gregor, Fujs Štefan, Martín Juan F, Petković Hrvoje   +14 more
doaj   +1 more source

Neuroprotective effects of tacrolimus (FK506) in a model of ischemic cortical cell cultures: Role of glutamate uptake and FK506 binding protein 12 kDa

Neuroscience, 2006
The mechanisms underlying the neuroprotective effects of the immunosuppressant tacrolimus, observed in vivo, remain unclear. Here we quantify these effects in vitro, and evaluate the potential involvement of the glutamate and/or immunophilin FK506 binding protein 12 kDa in tacrolimus-induced neuroprotection.Primary cultures of neurons and astrocytes ...
Labrande, Christelle, Velly, Lionel, Canolle, Benoit, Guillet, Benjamin, Masmejean, Frédérique, Nieoullon, André, Pisano, Pascale   +6 more
openaire   +3 more sources

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Comparative clinical pharmacokinetics of tacrolimus in paediatric and adult patients.

, 2001
Tacrolimus is a potent immunosuppressive agent used to prevent allograft rejection. The pharmacokinetics of tacrolimus have been studied in healthy volunteers and transplant recipients, mostly by using immunoassays to measure tacrolimus in plasma or ...
Wallemacq, Pierre, Verbeeck, Roger-K.
core   +1 more source

Engineering Immunoregenerative Therapy via an Immunomodulatory Binary Pharmacology Hydrogel Depot for Prolonged Allograft Survival

Advanced Science, EarlyView.
An immunomodulatory hydrogel (iGEL) forms spontaneously upon subcutaneous injection, acting as a tissue‐adhesive depot. It releases anti‐rejection and regenerative agents in response to inflammation, suppressing T‐cell activity, promoting vascular repair, and restoring allograft function without systemic immunosuppression.
Ning Wang, Ruiqi Sun, Yang Fu, Zhonghan Wu, Xinyu Tong, Hong Tang, Wentao Zhao, Zhi Liang, Jintao Zheng, Yanan Guan, Ke Zhou, Penghong Song, Shusen Zheng, Hangxiang Wang, Haiyang Xie   +14 more
wiley   +1 more source

Study of the Change Factors of Tacrolimus Consentration in Serum : From Viewpoint of Serum Protein Binding

, 2005
P(論文)Tacrolimus (FK506), which is a potent imuunosuppressive drug, has the excellent effect for prevention of rejection after on organ transu;oanttation.
本屋, 敏郎, モトヤ, トシロウ, オガタ, ケンジ, 60166345, 1022, 1021, 1020, 徳永, 仁, 1019, 1018, フジタ, ケンイチ, 山崎, 啓之, 1017, 1016, 1015, 1014, 1013, 1012, アリモリ, カズヒコ, 有森, 和彦, 緒方, 賢次, Tokunaga, Jin, 高村, 徳人, 1032, 1031, 1030, YAMASAKI, Keishi, 1029, 1000020369169, 1028, 1027, 1026, 1025, 1024, MOTOYA, Toshiro, 1000060166345, 1023, 20369169, 9000002747927, Takamura, Norito, 60369171, 9000002747765, FUJITA, Kenichi, Ogata, Kenji, 9000002747919, ヤマサキ, ケイシ, 1000060369171, トクナガ, ジン, 藤田, 健一, 1000070253739, 1000090509580, タカムラ, ノリト, 9000002749098, 90509580, ARIMORI, Kazuhiko, 9000002861894, 9000002865696   +56 more
core   +2 more sources