Results 61 to 70 of about 11,965 (161)

The Top Five Advances in Solid Organ Transplantation in the Past Fifty Years

World Journal of Surgery, EarlyView.
Stephen J. Wigmore, Diana A. Wu
wiley   +1 more source

Design of Nanocarriers for Kidney Targeted Delivery of Nucleic Acid Therapeutics

Macromolecular Bioscience, Volume 26, Issue 7, July 2026.
Nucleic acid therapeutics have been investigated to expand their applications to renal genetic disorders. This review summarizes key considerations in the design and fabrication of nanocarriers for the systemic delivery of nucleic acid therapeutics to the kidneys.
Jun Hyuk Lee, Junku Han, Sehwan Park, Hyejung Mok   +3 more
wiley   +1 more source

FK506-binding protein contributes to tacrolimus distribution in red blood cells

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2021
Naoki Yoshikawa, Ayako Matsuo, Tsubasa Yokota, Tomomi Iwakiri, Ryuji Ikeda   +4 more
openaire   +2 more sources

Emerging Medications in Facial Nerve Recovery: A Systematic Review and Meta‐Analysis

OTO Open, Volume 10, Issue 3, July-September 2026.
Abstract Objective To systematically review the literature for medical therapies that promote facial nerve regeneration and recovery. Data Sources PubMed/Medline, Embase, and SCOPUS databases were searched for English‐language studies published from inception through May 2025.
Kimberly Chan, Cheng Ma, Bao Y. Sciscent, Andreacarola Urso, Neerav Goyal, Jessyka G. Lighthall   +5 more
wiley   +1 more source

Fk506 Binding Protein 12 Deficiency in Endothelial and Hematopoietic Cells Decreases Regulatory T Cells and Causes Hypertension

, 2011
Patients treated with the immunosuppressive drug tacrolimus (FK506), which binds FK506 binding protein 12 (FKBP12) and then inhibits the calcium-dependent phosphatase calcineurin, exhibit decreased regulatory T cells, endothelial dysfunction,
Piyali Chatterjee, Brett M. Mitchell, Deepa Talreja, Amy K. Banes-Berceli, Kristina J. Young, Valorie L. Chiasson   +5 more
core   +1 more source

Pretransplant Malnutrition Risk Components are Associated With Adverse Outcomes After Simultaneous Pancreas and Kidney and Solitary Pancreas Transplantation

Clinical Transplantation, Volume 40, Issue 7, July 2026.
ABSTRACT Background Malnutrition is common among patients with end‐organ disease. The impact of any criterion of malnutrition (weight loss, muscle depletion, fat depletion, inadequate oral intake, or reduced functionality) pretransplant among simultaneous pancreas‐kidney (SPK) or solitary pancreas transplant (SPT) recipients is understudied. Methods In
Katrina Kennedy, Jessa Engelken, Megan Rolfson, Angela Zhou, Mina L. Gibes, Najiyah Salwa, Didier Mandelbrot, Dixon Kaufman, Jon Odorico, Sandesh Parajuli   +9 more
wiley   +1 more source

FK506, an Immunosuppressive Drug, Induces Autophagy by Binding to the V-ATPase Catalytic Subunit A in Neuronal Cells

, 2017
The drug FK506 (tacrolimus, fujimycin) exerts its immunosuppressive effects by regulating the nuclear factor of the activated T-cell (NFAT) family of transcription factors.
Kim, Dongyoung, Kim, Young Jin, Marko-Varga, György, Kwon, Ho Jeong,, Kwon, Ho Jeong, Kim, Young Jin,, Yoo, Jong Shin,, Marko-Varga, György,, Lee, Ju Yeon, Yoo, Jong Shin, Kim, Dongyoung,, Lund University., Hwang, Hui Yun, Hwang, Hui Yun,   +13 more
core   +2 more sources

Early Post‐Kidney Transplant Treatment With Roxadustat Ameliorates Anemia and Reduces Blood Transfusion Needs in Inflamed Patients: A Case‐Matched Study

Clinical Transplantation, Volume 40, Issue 7, July 2026.
ABSTRACT Background Roxadustat is an oral hypoxia‐inducible factor prolyl‐hydroxylase inhibitor. Recent studies have shown no inferiority of roxadustat compared to erythropoietin in chronic kidney disease and in post‐transplant patients. We evaluated roxadustat versus erythropoiesis‐stimulating agents (ESAs) in very early posttransplant patients ...
Paolo Randone, Laura Valenza, Alberto Mella, Fabrizio Fop, Caterina Dolla, Ester Gallo, Ana Maria Manzione, Silvia Mingozzi, Rita Tarragoni, Enrico Sanna, Luigi Biancone   +10 more
wiley   +1 more source

European S2k guidelines on management of autoimmune blistering diseases in children and adolescents

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 7, Page 1137-1161, July 2026.
Autoimmune blistering disorders (AIBDs) in children are rare, challenging to diagnose and treat and often require immunosuppressants. Until now, no paediatric care guidelines existed. The EADV Task Force for AIBDs has developed the consensus‐based recommendations, enabling physicians to adopt a uniform, tailored treatment strategy to improve outcomes ...
A. Nanda, B. Tedbirt, C. Bodemer, M. C. Bolling, M. El Hachem, M. Nikolić, E. Benton, M. Caproni, D. De, D. Didona, K. Drenovska, M. Goebeler, M. Hertl, B. Horváth, M. Kasperkiewicz, D. Kiritsi, M. Larralde, A. V. Marzano, J. Meijer, D. F. Murrell, J. Powell, E. Sprecher, N. S. Chandran, M. M. Tomayko, S. Uzun, N. van Beek, H. Ott, A. Patsatsi, A. Torrelo, A. Welfringer‐Morin, E. Schmidt, P. Joly   +31 more
wiley   +1 more source

An Investigation of Autoantibodies against Tyrosine Hydroxylase in Patients with Vitiligo [PDF]

, 2012
Vitiligo is an acquired idiopathic hypomelanotic skin disorder characterised by depigmented macules due to loss of cutaneous melanocytes. Evidence suggests that autoimmunity plays a role in the pathogenesis of the disease, since antibodies and T cells ...
Rahoma, Sherif
core