Results 71 to 80 of about 11,965 (161)

Rap and rapalogs bind TRPML1 in vitro.

, 2019
(A) Lack of FK506 effect on ITRPML1. Representative ITRPML1 was shown. (B) Rap bound to immuno-purified EGFP-TRPML1 immobilized on Pro-A biosensors in a dose-dependent manner. (C) Dose-dependent Tem-TRPML1 binding. (D) Weak or nonspecific binding of Zota
Rong Shao (202747), Nirakar Sahoo (1923211), Chenlang Gao (6718490), Xiaoli Zhang (135098), Dan Li (106345), Qiong Gao (13880), Ken Inoki (6718493), Tadashi Eguchi (1388379), Wei Chen (23863), Han Zhao (130768), Fumitaka Kudo (1388382), Xueni Yan (6718484), Shiyi Wang (6066389), Haoxing Xu (70454), Benfang Ruan (6718496), Yao Yao (335996), Meimei Yang (6718487), Junsheng Yang (606741), Lin Su (548272)   +18 more
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Studies on disposition of tacrolimus after topical application using several experimental models including a new hybrid skin-model [PDF]

, 2014
ハイブリッド型皮膚モデルを含めた各種実験モデルを用いて、皮膚適用後のタクロリムスの吸収動態に影響する要因を調査した。角質層のバリア機能に依存したタクロリムスの全身吸収が、ヘアレスラットのモデルとこの新しいハイブリッド型モデルで示された。経表皮水分蒸散量を前もって測定することがこの全身移行を回避するのに有効である。炎症皮膚において、真皮に漏出した血清タンパク質への結合がタクロリムスの全身移行の遅延を引き起こすが、血流の増加や血管透過性の上昇は、血中濃度が上昇する原因となることが示された。本研究の結果は ...
関, 俊暢
core  

The structure of a Burkholderia pseudomallei immunophilin–inhibitor complex reveals new approaches to antimicrobial development

, 2011
Mips (macrophage infectivity potentiators) are a subset of immunophilins associated with virulence in a range of micro-organisms. These proteins possess peptidylprolyl isomerase activity and are inhibited by drugs including rapamycin and tacrolimus.
O'Shea, Katherine, Richard W. Titball, Katherine O'Shea, Titball, Richard W, Norville, Isobel H, Gabriele Varani, Isobel H. Norville, Nicholas J. Harmer, Mitali Sarkar-Tyson, Sarkar-Tyson, Mitali, Varani, Gabriele, Suxin Zheng, Harmer, Nicholas J, Zheng, Suxin   +13 more
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Pharmacological modulation and manipulation of cancer drug resistance [PDF]

, 2010
The aim of this project was to investigate pharmacological methods of overcoming resistance in cancer. Novel compounds, targeted therapies and non-steroidal anti-inflammatory drugs (NSAIDs) were examined for their potential to modulate and manipulate ...
Devery, Aoife
core  

Localization of calcineurin/NFAT in human skin and psoriasis and inhibition of calcineurin/NFAT activation in human keratinocytes by cyclosporin A

, 2002
Systemic cyclosporin A and tacrolimus are effective treatments for psoriasis. Cyclosporin A and tacrolimus block T cell activation by inhibiting the phosphatase calcineurin and preventing translocation from the cytoplasm to the nucleus of the ...
Saxton A, Reynolds NJ, Al-Daraji WI, Grant KR, Ryan K   +4 more
core   +2 more sources

Immunosuppressive drug interactions and resistance in mononuclear cells from renal transplant patients [PDF]

Existing anti-rejection drug regimes are inadequate since patients receive drugs despite serious side effects and poor response. New drugs are being developed which ultimately may allow for prescribing of rational, patient-specific immunosuppressive ...
Delaney, Michael Paul
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Configuration, optimization and evaluation of a novel instrumental platform for automated SPE-LC-MS/MS analysis of drugs in whole blood [PDF]

, 2013
The thesis describes the configuration, optimization and evaluation of a novel instrumental platform for fully automated SPE-LC-MS/MS analysis of small molecules, such as drugs, in whole blood. The immunosuppressant Cyclosporine A was chosen as a model
Yu, Qianqian
core  

Predicting acute cellular rejection after liver transplantation: form liver function test to immune monitoring [PDF]

, 2013
In recent years, the main end point of immunosuppressive therapy after liver transplantation has moved from the prevention of acute cellular rejection (ACR) toward the preservation of long-term graft function and prevention of immunosuppression-related ...
Germani, Giacomo
core  

FK506, an Immunosuppressive Drug, Induces Autophagy by Binding to the V‑ATPase Catalytic Subunit A in Neuronal Cells

, 2016
The drug FK506 (tacrolimus, fujimycin) exerts its immunosuppressive effects by regulating the nuclear factor of the activated T-cell (NFAT) family of transcription factors.
György Marko-Varga (1351878), Jin Young Kim (271185), Dongyoung Kim (1440163), Ju Yeon Lee (1471039), Jong Shin Yoo (173825), Ho Jeong Kwon (43971), Hui-Yun Hwang (3350861)   +6 more
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Mycophenolate mofetil modulates adhesion receptors of the beta I integrin family on tumor cells: impact on tumor recurrence and malignancy

, 2005
Background: Tumor development remains one of the major obstacles following organ transplantation. Immunosuppressive drugs such as cyclosporine and tacrolimus directly contribute to enhanced malignancy, whereas the influence of the novel compound ...
Natsheh Iyad, Blaheta Roman A, Müller Iris, Makarević Jasmina, Natsheh, Iyad Y. M., Müller, Iris, Beecken Wolf-Dietrich, Engl Tobias, Jonas Dietger, Jasmina Makarević, Wolf-Dietrich Beecken, Beecken, Wolf-Dietrich, Iris Müller, Relja Borna, Roman A Blaheta, Dietger Jonas, Blaheta, Roman A., Makarević, Jasmina, Tobias Engl, Iyad Natsheh, Jonas, Dietger, Borna Relja, Relja, Borna, Engl, Tobias A.   +23 more
core   +1 more source