Results 81 to 90 of about 11,965 (161)

Xenobiotic metabolism: the effect of acute kidney injury on non-renal drug clearance and hepatic drug metabolism.

, 2014
Acute kidney injury (AKI) is a common complication of critical illness, and evidence is emerging that suggests AKI disrupts the function of other organs.
John Dixon, Philips, B, Dixon, J, Lane, K, Macphee, I, Katie Lane, Barbara Philips, Iain MacPhee   +7 more
core   +1 more source

Sphingosine 1-phosphate modulates antigen capture by murine langerhans cells via the S1P2 receptor subtype

, 2012
Dendritic cells (DCs) play a pivotal role in the development of cutaneous contact hypersensitivity (CHS) and atopic dermatitis as they capture and process antigen and present it to T lymphocytes in the lymphoid organs.
Kleuser, Burkhard (Prof. Dr. rer. nat.), Radeke, Heinfried H., Japtok, Lukasz, Heinfried H Radeke, Kleuser, Burkhard, Jeong, Se Kyoo, Wolfgang Bäumer, Burkhard Kleuser, Katrin Schaper, Heinfried H. Radeke, Schaper, Katrin, Lukasz Japtok, Bäumer, Wolfgang, Se Kyoo Jeong   +13 more
core   +1 more source

Análise da atividade antiinflamatória do metotrexato e da ciclosporina A, no modelo da pleurisia induzida pela carragenina, em camundongos [PDF]

, 2003
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde.
Dalmarco, Eduardo Monguilhott
core  

The Impact of CYP3A5 Variation and Pregnancy on the Metabolic Disposition of Calcineurin Inhibitors

, 2012
Thesis (Ph.D.)--University of Washington, 2012The calcineurin inhibitors (CNI) — cyclosporine A (CsA) and tacrolimus remain the backbone of immunosuppression therapy for most organ transplant patients despite their serious side effects, such as chronic ...
Zheng, Songmao
core   +1 more source

Identification of small-molecule inhibitors of calcineurin-NFATc signaling that mimic the PxIxIT motif of calcineurin binding partners

, 2015
Calcineurin (CN), a serine and threonine protein phosphatase that depends on Ca(2+) and calmodulin for its activity, is the target of the immunosuppressant drugs cyclosporin A (CsA) and tacrolimus (FK506). CN dephosphorylates and activates members of the
Pérez-Riba, M. (Mercè), Lozano-Moreda, T. (Teresa), Aranguren-Ibáñez, A. (Álvaro), Lasarte, J.J. (Juan José), Pardo, L. (Leonardo), Nunes, V. (Virginia), Matsoukas, M.T. (Minos-Timotheos)   +6 more
core  

Early Proteomic Alterations in Non-segmental Vitiligo Skin Following Treatment with Topical Tacrolimus. [PDF]

Dermatol Ther (Heidelb)
Haulrig MB, Kabatnik S, Skov L, Løvendorf MB, Dyring-Andersen B.   +4 more
europepmc   +1 more source

Diverse effects of calcineurin in vascular smooth muscle cells: physiological activators and the controversial actions of clinical inhibitors. [PDF]

Front Pharmacol
Nolze A, Grossmann C.
europepmc   +1 more source

Comparing Whole-Blood and Plasma Tacrolimus Intra-Patient Variability for Predicting Allograft Rejection in Kidney Transplantation. [PDF]

Clin Transl Sci
Xia Z, Yu H, Park JM, Zhu HJ.
europepmc   +1 more source

Brewing an Interaction: Non-commercial Green Tea-Associated Supratherapeutic Tacrolimus Levels Presenting With Gastrointestinal Symptoms. [PDF]

Cureus
Modi R, Patel F, Chag A, Joshi MR.
europepmc   +1 more source

Synthesis of pyrrole-based inhibitors of the macrophage infectivity potentiator proteins

, 2017
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Organic and Bioorganic Chemistry Supervisors: Prof. Dr. Ulrike Holzgrabe PharmDr.
Škoda, Josef
core