Results 81 to 90 of about 11,352 (258)

Stereoretentive Nucleophilic Aromatic Substitution Accesses Atropisomeric 4‐Amino‐N‐Arylquinolinium Salts

Chemistry – A European Journal, EarlyView.
Quinolin‐4‐ones were converted to chloroquinolinium salts, allowing formation of axially chiral aminoquinolinium salts via an enantioretentive SNAr reaction with a variety of amine nucleophiles. The salts have a high rotational barrier, with a racemization half‐life of ∼1000s of years.
Darren Holmes, Nia Foster, Saima Ansari, Paul Kavanagh, Paul Dingwall, Peter C. Knipe   +5 more
wiley   +1 more source

Integration bile acid metabolomics and gut microbiome to study the anti-liver fibrosis effects of total alkaloids of Corydalis saxicola Bunting

Chinese Medicine
Background Bile acids and gut microbiota participate in the pathogenesis of liver fibrosis (LF). The total alkaloids of Corydalis saxicola Bunting (TACS) is a traditional Chinese medicine extract that has been used to treat LF, but the underlying ...
Qianyi Wang, MeiLing Zhang, Mingwei Meng, Zhuo Luo, Ziping Pan, Lijun Deng, Jinghua Qin, Bingjian Guo, Dan Zhu, Yanmin Zhang, Hongwei Guo, Yonghong Liang, Zhiheng Su   +12 more
doaj   +1 more source

Mechanistic insights into cortical network entrainment by tACS and tDCS: A computational modeling approach

Brain Research Bulletin
Non-invasive brain stimulation techniques such as transcranial alternating current stimulation (tACS) and transcranial direct current stimulation (tDCS) are increasingly explored for modulating large-scale brain oscillations associated with cognition ...
Sandeep Kumar Agnihotri, Jiang Cai
doaj   +1 more source

Impact of Distillation Column Design on Potential for the Integration of Mechanical Vapor Recompression

Chemie Ingenieur Technik, EarlyView.
Mechanical vapor recompression integration in distillation is analyzed, focusing on feed preheating and column pressure drop. Binary methanol–water and benzene–toluene separations are studied to identify optimal designs, which are further assessed in a bioethanol vacuum distillation sequence regarding energetic, ecological, and economic performance ...
Thorben Hochhaus, Sebastian Siepmann, Marcus Grünewald, Julia Riese   +3 more
wiley   +1 more source

Individualized frequency and montage tACS to engage theta-gamma coupling and enhance working memory in mild cognitive impairment

Frontiers in Psychiatry
Mild Cognitive Impairment (MCI) is a clinical prodromal stage of Alzheimer’s disease. Enhancing executive functions in patients with MCI could optimize cognitive compensatory mechanisms and slow cognitive decline.
Mina Mirjalili, Mina Mirjalili, Iryna S. Palamarchuk, Iryna S. Palamarchuk, Heather Brooks, Heather Brooks, Reza Zomorrodi, Reza Zomorrodi, Ashley Melichercik, Wei Wang, Wei Wang, Sean M. Nestor, Sean M. Nestor, Daniel M. Blumberger, Daniel M. Blumberger, Daniel M. Blumberger, Abhishek Datta, Christopher Bowie, Christopher Bowie, Bernadette Mdawar, Bernadette Mdawar, Kullervo Hynynen, Kullervo Hynynen, Sanjeev Kumar, Sanjeev Kumar, Sanjeev Kumar, Sanjeev Kumar, Tarek K. Rajji, Tarek K. Rajji, Tarek K. Rajji, Tarek K. Rajji   +30 more
doaj   +1 more source

Matching Heat Pump Configurations and Process Parameters for Cost‐Minimal Heat‐Integrated CO2 Capturing Process

Chemie Ingenieur Technik, EarlyView.
In a CO2 absorption process, it is investigated whether the adjustment of operating parameters facilitates the integration of different closed heat pump cycles considering various refrigerants. The influence of different integration concepts and electricity prices are investigated by means of resulting total annual costs.
Johannes Wloch, Marcus Grünewald, Julia Riese   +2 more
wiley   +1 more source

A Systematic Review on Disease‐Modifying Therapies in Parkinsonian Disorders

Clinical Pharmacology &Therapeutics, EarlyView.
Parkinsonian disorders, including Parkinson's disease, Lewy body dementia, multiple system atrophy, and progressive supranuclear palsy, are progressive neurodegenerative conditions with no treatment options to slow disease progression. This systematic review provides an overview of evidence of disease‐modifying therapies that have been evaluated in ...
Pepijn P.N.M. Eijsvogel, Lars M.G. Smits, Philip H.C. Kremer, Geert Jan Groeneveld   +3 more
wiley   +1 more source

Clinical Model‐Informed Precision Dosing Consult Service for Accelerating Personalized Medication in Pediatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor, Takanobu Nadai, Kei Irie, Wen Rui Tan, Sanjana Parikh, Anhar Hosawi, Matthijs W. van Hoogdalem, Ronaldo Morales Junior, Sonya Tang Girdwood, Abbie D. Leino, Kana Mizuno, Alexander A. Vinks, Tomoyuki Mizuno   +12 more
wiley   +1 more source

Research progress on the intervention of cognitive function using transcranial alternating current stimulation technology

Frontiers in Psychology
Transcranial Alternating Current Stimulation (tACS) is a non-invasive brain stimulation that stimulates the cerebral cortex through the output current to regulate neural excitability.
Qingchang Wu, Changli Wu, Jian Liu
doaj   +1 more source

Curriculum alignment with international graduate attribute standards in engineering education: The CPUT experience

The Curriculum Journal, EarlyView.
Abstract This paper presents a qualitative case study of how the Mechanical Engineering Diploma programme at Cape Peninsula University of Technology (CPUT) systematically aligned its curriculum with both national and international graduate attribute (GA) standards.
Ali Rugbani, Simphiwe Nqabisa
wiley   +1 more source