Results 81 to 90 of about 78,568 (253)

Development of a microfluidic setup for the isolation and imaging of immune cells

Current Directions in Biomedical Engineering
Specialised cells in the blood play an important role in controlling the immune responses. Thus, these cells are also valuable for the diagnosis and treatment of diseases such as autoimmune disorders and cancer.
Petzold Mandy, Behrens Stephan, Polk Christoph, Sonntag Frank, Schmieder Florian   +4 more
doaj   +1 more source

Phase-synchronized iTBS and tACS at 40 Hz gamma frequency: The impact on working memory performance and functional connectivity

Brain Stimulation
Background: Gamma oscillations are critical for cognitive functions. While phase-synchronized electric and magnetic stimulation can boost oscillatory brain activities in theta, alpha, and delta bands, the effects on gamma frequencies have not been ...
Benedikt Glinski, Min-Fang Kuo, Kiomars Sharifi, Michael A. Nitsche, Mohammad Ali Salehinejad   +4 more
doaj   +1 more source

Dual Blockade of LILRB1 and LILRB2 Enhances Antiviral Immune Responses in SIV Infection

Advanced Science, EarlyView.
Dual LILRB1/B2 blockade with mac20G10 reshapes myeloid activation during acute SIV infection by targeting LILRB1 and LILRB2 on myeloid cells. This treatment enhances CD80 expression on selected myeloid subsets and increases plasma IFN‐λ, IL‐8, and IL‐1RA.
Florian Meurisse, Sixtine Coindre, Anne Wijkhuisen, Romain Marlin, Laure Fournier Le Ray, Juliette Pons, Melyssa Yaugel‐Novoa, Véronique Avettand‐Fenoel, Laurent Abi‐Rached, Anne‐Sophie Gallouet, Francis Relouzat, Mael Gourves, Asier Saez‐Cirion, Hisashi Arase, Gerard Zurawski, Sandra Zurawski, Nathalie Dereuddre‐Bosquet, Roger Le Grand, Stéphanie Simon, Olivier Lambotte, Benoit Favier   +20 more
wiley   +1 more source

Machine Learning–Guided Surface Strain Engineering in Connected Platinum–Nickel Nanoparticle Catalysts for Advanced Oxygen Reduction Performance

Advanced Science, EarlyView.
Machine learning‐guided strain engineering enables highly active, durable, support‐free Pt–Ni nanonetwork catalysts for the oxygen reduction reaction. Analysis of a Pt‐based catalyst dataset identifies surface compressive strain as an effective descriptor associated with enhanced activity and provided practical design guidelines.
Aparna Chitra Sudheer, Gopinathan M. Anilkumar, Hidenori Kuroki, Yuuki Sugawara, Takeo Yamaguchi   +4 more
wiley   +1 more source

Beyond the Fixed Charge: A New On‐Tissue Derivatisation Strategy Employing Photoionisable Chromophores for Mass Spectrometry Imaging of Amino‐Containing Metabolites

Angewandte Chemie, EarlyView.
We introduce a novel chemical derivatisation strategy for the UV‐activated detection of elusive metabolites. Incorporation of a tocopherol‐active chromophore allows for the detection of tagged analytes as photoionised radical cations, selectively induced by a 266 nm laser.
Sofia R. McGowan, Andrew J. Tague, Ashna A. Kumar, Marie Ranson, Christopher J. T. Hyland, Shane R. Ellis   +5 more
wiley   +2 more sources

Selective enhancement of low-gamma activity by tACS improves phonemic processing and reading accuracy in dyslexia

bioRxiv, 2020
The phonological deficit in dyslexia is associated with altered low-gamma oscillatory function in left auditory cortex, but a causal relationship between oscillatory function and phonemic processing has never been established.
S. Marchesotti, Johanna Nicolle, I. Merlet, Luc H. Arnal, J. Donoghue, A. Giraud   +5 more
semanticscholar   +1 more source

Programmable Nanobody‐Targeting Chimeras Enable Intracellular Viral Protein Degradation

Advanced Science, EarlyView.
Nab‐TAC enables targeted degradation of HBV surface antigen (HBsAg) in vivo. By fusing nanobody‐based recognition domains with programmable proteasome‐recruiting degradation signals, Nab‐TAC reduces HBsAg levels in a hydrodynamic HBV mouse model. ABSTRACT Chronic hepatitis B virus (HBV) infection remains a major global health challenge, largely because
Max Yu‐Chen Pan, Ting‐Hui Lee, Tzu‐Ning Peng, Eva Yi‐Hsuan Wu, Yu‐Ting Chiu, Chih‐Chien Chiu, Hong Vinh Nguyen, Yuan‐Shao Pao, Ming‐Hong Chao, Richard Kuan‐Lin Lee, Han‐Chung Wu, Lily Hui‐Ching Wang   +11 more
wiley   +1 more source

Transcranial Alternating Current Stimulation (tACS) as a Tool to Modulate P300 Amplitude in Attention Deficit Hyperactivity Disorder (ADHD): Preliminary Findings

Brain Topography, 2020
Studies examining event-related potentials (ERP) in patients affected by attention deficit/hyperactivity disorder (ADHD) have found considerable evidence of reduced target P300 amplitude across different perceptual modalities.
I. Dallmer-Zerbe, Fabian Popp, Alexandra P. Lam, A. Philipsen, C. Herrmann   +4 more
semanticscholar   +1 more source

Pasta, a Versatile Transcriptomic Clock, Maps the Chemical and Genetic Determinants of Aging and Rejuvenation

Advanced Science, EarlyView.
Pasta is a transcriptomic aging clock built on an age‐shift learning framework and trained on 17 000 samples across 21 datasets. It accurately predicts relative biological age across tissues, platforms, and species, captures stemness‐to‐senescence transitions, and identifies age‐modulatory perturbations.
Jérôme Salignon, Maria Tsiokou, Patricia Marqués, Enriqueta Rodríguez‐Diaz, Hazel Ang, Federico Pietrocola, Christian G. Riedel   +6 more
wiley   +1 more source

Neural mechanisms underlying the after-effects of repetitive paired-pulse TMS with β tACS on the human primary motor cortex

Scientific Reports
We previously reported that repetitive paired-pulse transcranial magnetic stimulation (TMS; rPPS) synchronized to the peak phase of transcranial alternating current stimulation (tACS) at the β frequency induced long-lasting after-effects on primary motor
Hisato Nakazono, Katsuya Ogata, Tsubasa Mitsutake, Akinori Takeda, Emi Yamada, Shozo Tobimatsu   +5 more
doaj   +1 more source