Results 41 to 50 of about 6,101 (214)

SerpinA3 is an Endogenous TGF‐β Receptor Antagonist that Attenuates Cardiac Fibroblast Activation and Fibrotic Remodeling

Advanced Science, EarlyView.
SerpinA3 acts as an endogenous TGF‐β receptor antagonist that binds to the extracellular domain of TGFR‐1, thereby preventing TGFR‐1–TGFR‐2 complex formation. This receptor‐level blockade suppresses TGF‐β/Smad2/3 signaling, attenuates cardiac fibroblast activation, and extracellular matrix deposition, and ultimately alleviates pressure overload–induced
Hui Wang, Jieyu Cui, Chunlu Huang, Wanyi Guo, Tong Liu, Yi Zhu, Shuai Shao, Kangyin Chen, Jinlong He, Qiankun Bao   +9 more
wiley   +1 more source

Mechanistic insights into cortical network entrainment by tACS and tDCS: A computational modeling approach

Brain Research Bulletin
Non-invasive brain stimulation techniques such as transcranial alternating current stimulation (tACS) and transcranial direct current stimulation (tDCS) are increasingly explored for modulating large-scale brain oscillations associated with cognition ...
Sandeep Kumar Agnihotri, Jiang Cai
doaj   +1 more source

Ablation‐Immune Thermal Armor Via Microstructural‐Compatibility Design for Extreme Thermal Conditions

Advanced Science, EarlyView.
This study unveils a microstructural‐compatibility design strategy that integrates reactive melt infiltration with plasma spraying to fabricate carbon fiber‐reinforced ZrC‐SiC composites. The deliberate incorporation of SiC into the ZrC coating releases heat accumulation, suppresses detrimental lamellar ZrO2 formation, and reduces residual stress. This
Hongkang Ou, Lingxiang Guo, Bing Liu, Ziyi Yi, Yuyu Zhang, Jia Sun, Qiangang Fu   +6 more
wiley   +1 more source

Individualized frequency and montage tACS to engage theta-gamma coupling and enhance working memory in mild cognitive impairment

Frontiers in Psychiatry
Mild Cognitive Impairment (MCI) is a clinical prodromal stage of Alzheimer’s disease. Enhancing executive functions in patients with MCI could optimize cognitive compensatory mechanisms and slow cognitive decline.
Mina Mirjalili, Mina Mirjalili, Iryna S. Palamarchuk, Iryna S. Palamarchuk, Heather Brooks, Heather Brooks, Reza Zomorrodi, Reza Zomorrodi, Ashley Melichercik, Wei Wang, Wei Wang, Sean M. Nestor, Sean M. Nestor, Daniel M. Blumberger, Daniel M. Blumberger, Daniel M. Blumberger, Abhishek Datta, Christopher Bowie, Christopher Bowie, Bernadette Mdawar, Bernadette Mdawar, Kullervo Hynynen, Kullervo Hynynen, Sanjeev Kumar, Sanjeev Kumar, Sanjeev Kumar, Sanjeev Kumar, Tarek K. Rajji, Tarek K. Rajji, Tarek K. Rajji, Tarek K. Rajji   +30 more
doaj   +1 more source

Cancer‐Associated Fibroblasts Promote Glucose Metabolic Reprogramming and Progression of Triple‐Negative Breast Cancer via Exosomal circFAD104‐Mediated Intercellular Communication

Advanced Science, EarlyView.
CAF‐derived exosomes deliver circFAD104 into TNBC cells, where it acts as a molecular scaffold that bridges the E3 ligase MARCHF8 and PGM1, promoting MARCHF8‐mediated K48‐linked ubiquitination and proteasomal degradation of PGM1. Loss of PGM1 redirects glucose‐phosphate flux from glycogen synthesis toward glycolysis, thereby driving stemness, EMT, and ...
Lei Wang, Xiaoyan Li, Yiran Liang, Yifei Wang, Yuhan Jin, Jianing Wang, Dan Luo, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Wenjing Zhao, Bing Chen, Lijuan Wang, Qifeng Yang   +16 more
wiley   +1 more source

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source

Effects of tACS-Like Electrical Stimulation on On-Center Retinal Ganglion Cells: Part I

Eye and Brain, 2021
Franklin R Amthor, Christianne E Strang Department of Psychology, The University of Alabama at Birmingham, Birmingham, AL, 35294-1170, USACorrespondence: Franklin R AmthorDepartment of Psychology, The University of Alabama at Birmingham, 1300 University ...
Amthor FR, Strang CE
doaj  

Interleukin‐1α Mediates Pancreatic Fibroblast Activation, Regulates Immune Cell Recruitment and Fibrosis in Acute and Chronic Pancreatitis

Advanced Science, EarlyView.
During pancreatitis, IL‐1α is released from necrotic acinar cells. In response to IL‐1α, pancreatic fibroblasts release chemokines and cytokines that regulate the recruitment of immune cells to the damaged organ. Furthermore, IL‐1α primes fibroblasts, resulting in increased tissue fibrosis during chronic pancreatitis.
Hala Mazloum, Shenja Buchholz, Hanna Schifter, Sabine Ameling, Leif Steil, Ben Lewin Becker, Elke Hammer, Georg Homuth, Uwe Völker, Barbara M. Bröker, Lukas Zierke, Frank Ulrich Weiss, Juliane Glaubitz, Matthias Sendler   +13 more
wiley   +1 more source

A Multi‐Scale Computational Framework for Evaluating Wireless Neuromodulation Feasibility via Magnetoelectric Nanoparticles

Advanced Science, EarlyView.
A multiscale computational framework links single‐nanoparticle magnetoelectric behavior to tissue‐level electric field distributions, integrating experimental data from nanoparticle characterization and in vitro stimulation setups. Applied to a cortical slice configuration, the framework predicts optimal MENP concentrations and stimulation parameters ...
Marta Bonato, Elric Zhang, Emma Chiaramello, Serena Fiocchi, Giulia Suarato, Valentin Gantenbein, Nathalia Cancino‐Fuentes, Alejandro Suarez‐Perez, Maria V. Sanchez‐Vives, Salvador Pané, Marta Parazzini   +10 more
wiley   +1 more source

A Prospective Study of the Impact of Transcranial Alternating Current Stimulation on EEG Correlates of Somatosensory Perception

Frontiers in Psychology, 2018
The (8–12 Hz) neocortical alpha rhythm is associated with shifts in attention across sensory systems, and is thought to represent a sensory gating mechanism for the inhibitory control of cortical processing.
Danielle D. Sliva, Christopher J. Black, Paul Bowary, Paul Bowary, Paul Bowary, Uday Agrawal, Juan F. Santoyo, Noah S. Philip, Noah S. Philip, Noah S. Philip, Benjamin D. Greenberg, Benjamin D. Greenberg, Benjamin D. Greenberg, Christopher I. Moore, Stephanie R. Jones, Stephanie R. Jones   +15 more
doaj   +1 more source