Results 191 to 200 of about 48,744 (288)

Native habitat affinities predict fish invasions with post‐invasion habitat shifts

Journal of Animal Ecology, Volume 95, Issue 9, Page 1762-1777, September 2026.
Initial invasion success is gated by native pre‐adaptations, but post‐invasion establishment is characterized by habitat shifts. We demonstrate that forecasting risk based solely on native niches severely underestimates future ecological impacts, and we provide an empirically validated watchlist of future invaders.
Shahar Chaikin, Tal Gavriel, Avery Deveto, Shahar Malamud, Jonathan Belmaker   +4 more
wiley   +1 more source

A QbD-based method for the simultaneous determination of tadalafil, terazosin, and tamsulosin using organic-solvent free mixed-micellar HPLC: a sustainable green approach. [PDF]

BMC Chem
Alrashdi YBA, Magdy G, Osman MM, Alamir SG, El Deeb S, Al-Harrasi A, Ibrahim AE.   +6 more
europepmc   +1 more source

A translocation within the Ogataea species complex alters local subtelomeric chromatin while maintaining overall genome organization. [PDF]

G3 (Bethesda)
Lundberg TJ, Lande NM, Tourevski D, Figueroa R, Hanson SJ, Klocko AD.   +5 more
europepmc   +1 more source

Population Pharmacokinetics and Exposure‐Response Analyses of Savolitinib Alone or in Combination With Osimertinib in Patients With Locally Advanced or Metastatic Solid Tumors

Clinical and Translational Science, Volume 19, Issue 9, September 2026.
ABSTRACT Savolitinib (ORPATHYS) is an oral, highly selective inhibitor of the mesenchymal–epithelial transition (MET) receptor tyrosine kinase that has demonstrated clinical activity across multiple advanced solid tumors. A comprehensive population pharmacokinetics analysis using cumulative data from 998 patients across 10 clinical studies ...
Azar Shahraz, Thibaud Derippe, Kiran Kumar Kode, Jessica Allmond, Simon Nelson, Ike Igwegbe, Aarti Sawant‐Basak, Karthick Vishwanathan, Kowser Miah   +8 more
wiley   +1 more source

Chromatin accessibility classification of TAD boundaries discloses new architectural proteins. [PDF]

Nucleic Acids Res
Jácome-López K, Ledesma-Domínguez L, Esquivel-López A, Pérez-Molina R, Pénagos-Puig A, Aguilar-Lomas A, Gómora-García JC, Furlan-Magaril M.   +7 more
europepmc   +1 more source

Advances in Functional Genomics for Human Health. [PDF]

Genes (Basel)
Gonzales PR.
europepmc   +1 more source

Quantitative analysis of DNA‐GATA1 binding alterations linked to hematopoietic disorders

The FEBS Journal, Volume 293, Issue 17, Page 5149-5169, September 2026.
Native holdup allows the quantitative determination of affinities between full‐length transcription factors and DNA. Mutations in either the protein or the DNA can modulate binding strength, which can be precisely quantified using this approach. Applied to GATA1, it revealed mutations that alter DNA binding.
Boglarka Zambo, Bastien Morlet, Luc Negroni, Orsolya Mózner, Balázs Sarkadi, Gilles Travé, Gergo Gogl   +6 more
wiley   +1 more source

CTCF aligns single-cell TAD-like domain boundaries and stabilizes long-range active chromatin clusters. [PDF]

Sci Adv
Chen Z, Li X, Dai Y, Shao K, Sun H, Wu N, Yan J, Zhang Y, Yu M.   +8 more
europepmc   +1 more source

RAB4A acts as a negative feedback regulator of extracellular vesicle secretion during TGF‐β signaling

The FEBS Journal, Volume 293, Issue 17, Page 5340-5362, September 2026.
TGF‐β signaling regulates extracellular vesicle (EV) release in cancer cells by modulating the expression and activity of genes associated with EV biogenesis. The TGF‐β‐induced upregulation of RAB4A expression facilitates fast endosomal recycling, a process that limits the fusion of multivesicular bodies with the plasma membrane and EV secretion. Hence,
Dorival Mendes Rodrigues‐Junior, Maria Anastasia Doumani, Hao Fu, Jelle van den Bor, Olof Idevall‐Hagren, Aristidis Moustakas   +5 more
wiley   +1 more source

Add a TAD of duplication [PDF]

Nature Reviews Molecular Cell Biology, 2016
openaire   +1 more source