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TADs without borders

Nature Genetics, 2020
Genomes are highly organized in space and time. Compartments, topologically associating domains (TADs) and loops are three dimensional (3D) genome features that have been extensively studied. Among these three levels of organization, TADs have sparked the most debate. New microscopy data shed light on how TADs and their leaky borders contribute to gene
Irene Farabella, Marc A. Marti-Renom
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TADs do not stay in the loop

Molecular Cell, 2022
In a recent issue of Science, Gabriele et al. have, for the first time, quantified the dynamics of a topologically associating domain (TAD) in live cells by coupling super-resolution imaging and computational modelling, concluding that a TAD spends most of its life in a "partially extruded state" and that CTCF-CTCF loops are rare.
Davide, Michieletto, Wendy A, Bickmore
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Pervasive RNA-Binding Protein Enrichment on TAD Boundaries Regulates TAD Organization

open access: yesNucleic Acids Research
Abstract Mammalian genome is hierarchically organized by CTCF and cohesin through loop extrusion mechanism to facilitate the organization of topologically associating domains (TADs). Mounting evidence suggests additional factors/mechanisms exist to orchestrate TAD formation and maintenance.
Huating Wang, Hao Sun, Yulong Qiao
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NIMH's TADS: More than just a tad of progress?

Cognitive and Behavioral Practice, 2005
The Treatment for Adolescents With Depression Study (TADS) derives substantial public health significance from its head-to-head comparisons of carefully administered medication versus a carefully crafted cognitive-behavioral therapy in youth with major depression, the first major clinical trial of its kind.
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TADs: an evolutionary road to success

Dental Update, 2014
This is a literature search about the clinical use of temporary anchorage devices (TADs) as a means of providing effective orthodontic anchorage. It takes the reader through a journey from the initial description of the technique to the enormous popularity TADs are currently experiencing in clinical practice.
Audrey, Pace, Jonathan, Sandler
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All-digital MEMS gyro-sensor using TAD-digital-synchronous-detection (TAD-DSD) By TAD-ADPLL

2015 IEEE SENSORS, 2015
As sensor digitization for IoT-applications, this paper presents an all-digital MEMS gyro-sensor circuit method, using TAD (Time-A/D converter)-based digital synchronous detection (TAD-DSD) by applying entirely all-digital time-domain processing, which uses no conventional methods such as analogmixers, -filters and -ADCs.
Takamoto Watanabe, Shigenori Yamauchi
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TADs as the Caller Calls Them

Journal of Molecular Biology, 2020
Developments in proximity ligation methods and sequencing technologies have provided high-resolution views of the organization of the genome inside the nucleus. A prominent feature of Hi-C maps is regions of increased self-interaction called topologically associating domains (TADs).
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