Results 111 to 120 of about 16,904 (242)

Exploring Autophagy Inducing Molecules: Targeting Diverse Pathways in Alzheimer's Disease Management

Medicinal Research Reviews, Volume 46, Issue 1, Page 272-298, January 2026.
ABSTRACT Neurodegenerative disorders, including Alzheimer's disease (AD), impose a significant burden on society due to their progressive nature and the associated healthcare costs. Autophagy, a vital cellular degradation process, has emerged as a promising therapeutic target in these disorders.
Baljinder Singh, Shubham Mahajan, Sadikalmahdi Abdella, Rehan Khan, Sanjay Garg   +4 more
wiley   +1 more source

Effect of tadalafil on erectile function in patients after robotic-assisted radical prostatectomy with unilateral or bilateral nerve sparing

Urological Science, 2019
Objective: Erectile dysfunction (ED) is a major complication of radical prostatectomy. Despite advances in surgical techniques, the postoperative continence and potency rates are still not satisfactory.
I-Yen Lee, Min-Che Tung, Chao-Yu Hsu, Jue-Hawn Yin, Yu-Kang Chang, Wei-Chun Weng, Li-Hua Huang, Zhon-Min Huang, Cheng-Kuang Yang, Yen-Chuan Ou   +9 more
doaj   +1 more source

Physiologically‐Based Pharmacokinetic Modeling to Support Pediatric Clinical Development: An IQ Working Group Perspective on the Current Status and Challenges

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 1, January 2026.
ABSTRACT Pediatric extrapolation strategies issued by health authorities have streamlined pediatric drug development and reduced the unnecessary burden of conducting pediatric clinical studies. In line with these strategies, physiologically based pharmacokinetic (PBPK) models have been utilized extensively for initial dosing regimen and sampling ...
James W. T. Yates, Michael Zientek, Kunal S. Taskar, Wen Lin, Tycho Heimbach, Stefan Willmann, Jessica Rehmel, Neil Parrott, Michael Hanley, Justine Badee, Yuan Chen, Susan Cole, Loeckie De Zwart, Sebastian Haertter, Rongrong Jiang, Masakatsu Kotsuma, Guiqing Liang, Yu‐Wei Lin, Jing Liu, Ying Ou, Juliane Rascher, Naveed A. Shaik, Jan Wahlstrom, Xiaofeng Wang, Guangqing Xiao, Ka Lai Yee, S. Y. Amy Cheung   +26 more
wiley   +1 more source

Histomorphological Effects of Tadalafil on the Liver of Adult Wistar Rat

Journal of Applied Sciences and Environmental Management
Tadalafil is used to treat erectile dysfunction and improve exercise capacity in people with pulmonary arterial hypertension. It promotes blood circulation to the penis during sexual stimulation, thus facilitating the occurrence of an erection.
P. O. Onyilo, B. O. Samuel
doaj   +1 more source

Enhanced Bioavailability of Tadalafil after Intranasal Administration in Beagle Dogs

Pharmaceutics, 2018
Tadalafil is an oral selective phosphodiesterase type-5 inhibitor with demonstrated efficacy and safety that is used to treat erectile dysfunction. The purpose of this study is to compare the pharmacokinetic properties of tadalafil after conventional ...
Jeong-Soo Kim, Min-Soo Kim, In-hwan Baek
doaj   +1 more source

Supplemental Oxygen Decreases Cardiac Effort in Pulmonary Arterial Hypertension

Pulmonary Circulation, Volume 16, Issue 1, January 2026.
ABSTRACT In this single‐blind, crossover pilot study, supplemental oxygen at 2 L/min during 6‐min walk test reduced Cardiac Effort in patients with pulmonary arterial hypertension, while 6‐min walk distance remained unchanged. This decrease suggests improved physiology for an unchanged workload.
Kyle Norton, Bishal Gyawali, Deborah Haight, R. James White, Daniel Lachant   +4 more
wiley   +1 more source

Tadalafil Alone or in Combination with Tamsulosin for the Management for LUTS/BPH and ED

Current Urology Reports, 2020
Aim of our systematic review is to evaluate and summarize the efficacy and safety of tadalafil alone or in combination with tamsulosin for the management of lower urinary tract symptoms (LUTS)/benign prostatic hyperplasia (BPH) and erectile dysfunction ...
A. Sebastianelli, P. Spatafora, Simone Morselli, L. Vignozzi, Sergio Serni, Kevin T. McVary, Steven A. Kaplan, Stavros Gravas, Christopher Chapple, M. Gacci   +9 more
semanticscholar   +1 more source

Cooling down for going up: Could selective ‘brain chilling’ mitigate high‐altitude illness?

Experimental Physiology, EarlyView.
Adnan Haq, Damian M. Bailey
wiley   +1 more source

Prognostic Value of Acute Vasoreactivity in Chronic Thromboembolic Pulmonary Hypertension

Pulmonary Circulation, Volume 16, Issue 1, January 2026.
ABSTRACT Vasoreactivity, which refers to the reduction of mean pulmonary arterial pressure in response to inhaled vasodilators, is a well‐established metric for prognostication and treatment selection in patients with pulmonary arterial hypertension. However, the role of vasoreactivity in chronic thromboembolic pulmonary hypertension is less studied ...
Justin A. G. Uphus, Jiun‐Ruey Hu, Shi Huang, Thomas M. Hofbauer, Adelheid Panzenboeck, Roela Sadushi‐Kolici, Inbal Shafran, Nika Skoro‐Sajer, Christian Gerges, Evan Brittain, Irene M. Lang   +10 more
wiley   +1 more source

Effect of Tadalafil on Prevention of Urethral Stricture after Direct Vision Internal Urethrotomy: A Prospective Cohort Study

Journal of Clinical and Diagnostic Research
Introduction: Urethral stricture recurrence following Direct Vision Internal Urethrotomy (DVIU) remains a significant challenge. Phosphodiesterase type-5 inhibitors (PDE5-Is), such as tadalafil, have been proposed to reduce fibrosis and stricture ...
Shyam Sundar Sarkar, Soumya Mondal, Debansu Sarkar   +2 more
doaj   +1 more source