Results 101 to 110 of about 9,923 (187)

Effects of the phosphodiesterase type-5 inhibitor tadalafil on nociception, morphine analgesia and tolerance in rats

, 2018
Aim: Tadalafil is a potent, selective and reversible inhibitor of phosphodiesterase type 5 (PDE5) enzyme breakdowning cyclic guanosine monophosphate (cGMP).
Yasar Tastemur, Arslan, Gokhan, Tastemur, Yasar, Ahmet Kemal Filiz, Filiz, Ahmet Kemal, Ercan Ozdemir, Ozdemir, Ercan, Taskiran, Ahmet Sevki, Ahmet Sevki Taskiran, Gokhan Arslan   +9 more
core   +1 more source

Postmortem Toxicology of Tadalafil in a Forensic Case

International Journal of Medical Toxicology and Forensic Medicine, 2023
Tadalafil is an inhibitor of the enzyme human cyclic guanosine monophosphate–specific phosphodiesterase, type 5 (PDE-5). A mild vasodilator, it is primarily used for the treatment of erectile dysfunction (ED), an increasingly common condition.
Maria Laura Schirripa, Letizia Gnetti, Edda Emanuela Guareschi   +2 more
doaj  

The effect of tadalafil therapy on kidney damage caused by sepsis in a polymicrobial septic model induced in rats: a biochemical and histopathological study

International Brazilian Journal of Urology
Introduction Sepsis is an inflammatory reaction to bacteria involving the whole body and is a significant cause of mortality and economic costs. The purpose of this research was to determine whether tadalafil exhibits a preventive effect on sepsis in a ...
Erdal Benli, Sema Nur Ayyildiz, Selma Cirrik, Sibel Koktürk, Abdullah Cirakoglu, Tevfik Noyan, Ali Ayyildiz, Cankon Germiyanoglu   +7 more
doaj   +1 more source

Tadalafil and exercise capacity after fontan operation

, 2018
Background: Patients with congenital heart defects that have single functional ventricle undergo Fontan surgery. After the surgery, patients will develop reduced capacity for physical activity and exercise.
Sara Lotfian, Zahra Alizadeh, Mohammad Mehdi Peighambari, Zahra Khajali, Morteza Rouhani, Maryam Golari, Bahar Galeshi   +6 more
core   +1 more source

Histopathological and real–time PCR analysis of alterations in the rat brain within the Glycerol–induced Crush Syndrome

Revista Científica
This study attempted to examine the neuroprotective benefits of vitamin C and tadalafil in an experimental crush syndrome model induced by intramuscular glycerol injection in rats, using histopathological and real–time polymerase chain reaction.
Ayşegül Bulut, Mehmet Tuzcu, Mehmet Burak Ateş, Şeyma Hazal Çetin, Vedat Kaya   +4 more
doaj   +1 more source

Isolation and structural elucidation of a new tadalafil analogue in health supplements: bisprenortadalafil

, 2016
A new tadalafil analogue was found, along with nortadalafil, using HPLC-DAD during the inspection of a health product sold without official approval. The analogue was separated using a semi-preparative HPLC system and its structure was determined by a ...
Jongkook Lee (1632925), Han Na Park (2567368), Bogonda Ganganna (2567365), Sung-Kwan Park (2567362), Sun Young Baek (795019), Ji Hyun Lee (16823), Ji Hye Jeong (2567356)   +6 more
core   +1 more source

Tadalafil improves neurological function in the diabetic db/db mouse.

, 2016
Treatment of diabetic mice with tadalafil improves neurological function measured by MCV (A), SCV (B), Plantar test (C) and Tail flick test (D ...
LongFei Jia (3150060), Zheng Gang Zhang (95014), Lei Wang (6656), Michael Chopp (95019), Alexandra Szalad (692785), XueRong Lu (692786), Rui Lan Zhang (207929), Mei Lu (177815)   +7 more
core   +1 more source

Tadalafil increases axonal remodeling in diabetic db/db mice.

, 2016
Panels A to C show semi-thin toluidine blue-stained cross sections of sciatic nerves from a representative non-diabetic mouse (DM, A), diabetic mouse treated with saline (DB, B), and diabetic mouse treated with tadalafil (DBTA, C).
LongFei Jia (3150060), Zheng Gang Zhang (95014), Lei Wang (6656), Michael Chopp (95019), Alexandra Szalad (692785), XueRong Lu (692786), Rui Lan Zhang (207929), Mei Lu (177815)   +7 more
core   +1 more source

PERBANDINGAN PEMBERIAN SILDENAFIL DAN TADALAFIL DALAM PENGOBATAN BENIGN PROSTAT HIPERPLASIA DENGAN LOWER URINARY TRACT SYMPTOMS [PDF]

, 2016
Objektif: Membandingkan efikasi dari terapi tunggal sildenafil sitrat dan tadalafil sekali sehari dalam pengobatan benign prostat hiperplasia dengan lower urinary tract symptoms.
Ade Indra Mukti
core  

Improvement of Urodynamic Indices by Single Dose Oral Tadalafil in Men With Supra Sacral Spinal Cord Injury

Urology Journal, 2010
PURPOSE: To investigate the changes in urodynamic indices following a single dose of oral tadalafil in patients with supra sacral spinal cord injury (SCI).
Karim Taie, Dinyar Khazaeli, Hayat Moombeini, Mohammad Salari Panah firouzabadi   +3 more
doaj