Results 81 to 90 of about 21,239 (239)

Sexual Safety Signals of Common Antidiabetic Drugs: Insights From FAERS Disproportionality Analysis

Andrology, EarlyView.
ABSTRACT Background Erectile dysfunction is a prevalent and distressing complication of diabetes mellitus that markedly affects quality of life in male patients. Although the role of diabetes in erectile dysfunction is well‐established, potential drug‐induced sexual dysfunction associated with commonly prescribed antidiabetic medications remains ...
Shan Lin, Xuefeng Ding, Xin Dang, Qingyuan Zhan   +3 more
wiley   +1 more source

Tadalafil: an overview and the post-mortem toxicology of a case

International Journal of Medical Toxicology and Forensic Medicine, 2023
Tadalafil is an inhibitor of the enzyme human cyclic guanosine monophosphate–specific phosphodiesterase, type 5 (PDE-5). A mild vasodilator, it is primarily used for the treatment of erectile dysfunction (ED), an increasingly common condition.
Maria Laura Schirripa, Letizia Gnetti, Edda Emanuela Guareschi   +2 more
doaj   +1 more source

Digital Real-world Data Suggest Patient Preference for Tadalafil over Sildenafil in Patients with Erectile Dysfunction.

European Urology Focus, 2021
BACKGROUND Erectile dysfunction (ED) is a major care problem worldwide. Tadalafil and sildenafil are the two most common phosphodiesterase-5 inhibitors (PDE5is) used to treat ED.
Moritz von Büren, S. Rodler, Isabell Wiesenhütter, Florian Schröder, A. Buchner, C. Stief, C. Gratzke, C. Wülfing, Johannes von Büren   +8 more
semanticscholar   +1 more source

Artificial Intelligence in Patient Education: ChatGPT for Penile Prosthesis Surgery Counseling, a Likert Scale Analysis

Andrology, EarlyView.
Abstract Introduction Erectile dysfunction (ED) significantly impacts quality of life. For patients unresponsive to conservative treatments, penile prosthesis implantation represents an effective solution with high satisfaction rates. However, the complexity and sensitive nature of the procedure often generate multiple patient concerns.
Gabriele Tulone, Nicola Pavan, Rosa Giaimo, Alchiede Franco Simonato, Alfonzo Salzano, Davide Cosentino, Francesco Claps, Alchiede Simonato   +7 more
wiley   +1 more source

Tadalafil attenuates graft arteriosclerosis of aortic transplant in a rat model [PDF]

Iranian Journal of Basic Medical Sciences, 2015
Objective(s): Tadalafil can restore endothelial function and treat atherosclerosis. However, the effect of tadalafil on transplant arteriosclerosis remains unclear. In this study, we explore the effects of tadalafil on allograft vasculopathy.
Xu Ziqiang, Wang Jingjun, Zheng Jianjian, Liang Yong, Xia Peng   +4 more
doaj  

Evaluation of testosterone and prolactin hormones levels in erectile dysfunction patients after single oral dose of Tadalafil

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2008
Erectile dysfunction (ED) is defined as a consistent inability to sustain an erection sufficient for sexual intercourse. Tadalafil is a selective, reversible inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5 ...
Hayder Hamed Abed
doaj   +1 more source

Structure elucidation of sildenafil analogues in herbal products. [PDF]

, 2004
The structure of unknown compounds present in herbal products was elucidated using liquid chromatography-electrospray ionization-mass spectrometry, direct-infusion electrospray ionization-mass spectrometry, and nuclear magnetic resonance.
Bakker, F, Blok-Tip, L, Hamzink, M, Hartog, K D, Hove, J ten, Kaste, D de, Vredenbregt, M, Zomer, B   +7 more
core   +1 more source

Tadalafil enhances the therapeutic efficacy of BET inhibitors in hepatocellular carcinoma through activating hippo pathway.

Biochimica et Biophysica Acta - Molecular Basis of Disease, 2021
Bromodomain and extraterminal (BET) proteins are promising therapeutic targets for hematological and solid tumors. However, BET inhibitor monotherapy did not show a significant therapeutic benefit for hepatocellular carcinoma (HCC) in preclinical trials.
Deqiang Kong, Yuancong Jiang, Xiaolong Miao, Zelai Wu, Han Liu, W. Gong   +5 more
semanticscholar   +1 more source

The development of type 2 diabetes amongst sibling pairs in the South‐South region of Nigeria: The effect of genetics, environment and lifestyle

Diabetic Medicine, EarlyView.
Abstract Introduction Type 2 diabetes is a complex condition with a multifactorial pathogenesis. The pathogenesis is considered to be polygenic due to complex interactions between genetic/epigenetic and environmental factors. The aim of this study is to determine the genetic, environmental and lifestyle factors associated with the development of type 2
Sunny Chinenye, Ibi Erekosima, Adrian H. Heald, Gesiye Bozimo, Simon G. Anderson, Samuel Seidu, Kariba Akhidue, Adaeze Ugwu, Chioma Unachukwu, Ibitrokoemi Korubo, Kingsley Chukwuemeka Patrick‐Iwuanyanwu, Victoria Gomba, Uwoma Batubo, Victoria Akanatei, Victor Ken‐Uba, Iyeopu Siminialayi, Sokiprim Akoko, Justin Ideozu, Hamilton Opurum   +18 more
wiley   +1 more source

Tadalafil, a Long-Acting Inhibitor of PDE5, Improves Pulmonary Hemodynamics and Survival Rate of Monocrotaline-Induced Pulmonary Artery Hypertension in Rats

Journal of Pharmacological Sciences, 2009
The aim of this study was to assess the effect of tadalafil (0.5, 2.5, and 10 mg/kg per day) on the progression of pulmonary arterial hypertension (PAH) in early treatment and on the survival rate in late treatment on the monocrotaline (MCT)-induced PAH ...
Fusae Sawamura, Masami Kato, Kazuhisa Fujita, Takahiro Nakazawa, Anthony Beardsworth   +4 more
doaj   +1 more source