Results 71 to 80 of about 21,239 (239)

Efficacy and safety of tadalafil in a pediatric population with pulmonary arterial hypertension: phase 3 randomized, double-blind placebo-controlled study

Pulmonary Circulation, 2021
This study evaluated the efficacy and safety of tadalafil in pediatric patients with pulmonary arterial hypertension. This phase-3, international, randomized, multicenter (24 weeks double-blind placebo-controlled period; two-year, open-labeled extension ...
D. Ivy, D. Bonnet, R. Berger, G. Meyer, Simin K. Baygani, Baohui Li   +5 more
semanticscholar   +1 more source

Development of a skeleton-specific antibody and Au nanoparticle-based immunochromatographic sensor for simultaneous detection of various tadalafil adulterants in health food

Food and Agricultural Immunology, 2019
In this work, a rapid, convenient and sensitive Au nanoparticle-based immunochromatographic sensor (AuNPs-ICS) for simultaneous detection of various tadalafil adulterants in health food was established for the first time, based on one high affinity and ...
Fan He, Tingting Zou, Jinyi Yang, Hong Wang, Lihua Deng, Yuanxin Tian, Zhenlin Xu, Yuanming Sun, Hongtao Lei, Xuecai Tan, Yudong Shen   +10 more
doaj   +1 more source

Использование селективных ингибиторов аргиназы 2 и тадалафила в комбинированной коррекции гомоцистеин-индуцированной эндотелиальной дисфункции [PDF]

, 2015
Использование селективных ингибиторов аргиназы 2 в сочетании с тадалафилом на фоне моделирования гомоцистеин-индуцированной эндотелиальной дисфункции оказывало эндотелио- и кардиопротективное действие, выражающееся в предотвращении увеличения КЭД ...
Коклин, И. С.
core   +1 more source

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source

The effect of phosphodiesterase-5 inhibitor, tadalafil, on in vitro potassium chloride-induced contractions of isolated human ureteral tissue

Indian Journal of Urology, 2018
Introduction: Drugs causing ureteral relaxation are used for medical expulsive therapy (MET) for stones. We investigated the in vitro ability of tadalafil to cause relaxation of potassium chloride (KCl)-induced contractions of isolated human ureteral ...
M S Sakthivel, Ratna Prabha, Onkar Singh, Nitin S Kekre, Santosh Kumar   +4 more
doaj   +1 more source

New approaches of morfofunktional pharmacological correction of violations of cardiovascular system in experimental preeclampsia [PDF]

, 2016
Experimental Modeling ADMA-like preeclampsia administration to rats was performed by Nnitro-L-arginine methyl ester, from 14 to 20 days of pregnancy.
Gureev, V. V.
core   +2 more sources

Initial combination therapy of ambrisentan and tadalafil in connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH) in the modified intention-to-treat population of the AMBITION study: post hoc analysis

Annals of the Rheumatic Diseases, 2020
Objectives To evaluate initial combination therapy with ambrisentan plus tadalafil (COMB) compared with monotherapy of either agent (MONO), and the utility of baseline characteristics and risk stratification in predicting outcomes, in patients with ...
M. Kuwana, C. Blair, Tomohiko Takahashi, J. Langley, J. Coghlan   +4 more
semanticscholar   +1 more source

Polyglycolic Acid Polymer Versus Porcine Small Intestine Submucosa Graft After Plaque Incision in Peyronie's Disease: A Comparative Study

Andrology, EarlyView.
ABSTRACT Background Peyronie's disease (PD) with severe penile curvature often requires surgical correction through plaque incision and grafting (PIG). Objectives To compare surgical outcomes between polyglycolic acid polymer grafts and porcine small intestinal submucosa (SIS) grafts in patients undergoing PIG for PD.
Renan Trevisan Jost, Leonardo Seligra Lopes, Pedro Caetano Edler Zandoná, Jovânio Fernandes da Rosa, Pedro Fernandes Lessa, Felipe Placco Araujo Glina, Nívio Pascoal Teixeira, Sidney Glina   +7 more
wiley   +1 more source

Cost effectiveness of first-line oral therapies for pulmonary arterial hypertension: A modelling study [PDF]

, 2016
Background: In recent years, a significant number of costly oral therapies have become available for the treatment of pulmonary arterial hypertension (PAH).
A Drabinski, A Macchia, A Roman, AH Briggs, AJ Peacock, AJ Sutton, AM Keogh, B He, DB Badesch, Doug Coyle, EJ Mills, G Savarese, GE D’Alonzo, GJ Taylor, HA Ghofrani, J Letarte, John Swiston, Julie Blouin, Karen Lee, Kathryn Coyle, Khai Tran, L Guillevin, Lisa Mielniczuk, M Humbert, MC Garin, MD McGoon, Mike Innes, Mohammed F. Jabr, N Galie, N Galie, N Galie, N Galie, O Sitbon, RL Benza, RL Fleurence, RN Channick, SJ Pocock, T Thenappan, TR Einarson, VV McLaughlin, Y Ling, YF Chen, YG Zheng   +42 more
core   +2 more sources

Effect of low-dose tadalafil once daily on glycemic control in patients with type 2 diabetes and erectile dysfunction: a randomized, double-blind, placebo-controlled pilot study

Diabetology & Metabolic Syndrome, 2021
Background Phosphodiesterase type 5 inhibitors restore nitric oxide signaling, that plays a significant role in erectile function, and appears to counteract insulin resistance in animal and human models.
Min-Kyung Lee, Jae-Hyuk Lee, S. Sohn, S. Lee, T. Jeong, Sae-chul Kim   +5 more
semanticscholar   +1 more source