Results 61 to 70 of about 10,553 (193)

Effects of sildenafil and tadalafil on skin flap viability

, 2021
Vascular complication is one of the causes of skin flap healing failure. Sildenafil and tadalafil, a type-5 phosphodiesterase inhibitor, can improve flap viability, however, the action mechanisms involved in this process are still unclear.
Bernardes, Geraldo J S, Souza, Laila A C, Martinelli Klay, Carla Patricia, d'Acampora, Armando J, Lombardi, Tommaso, Souza, Rafael A C, Sudbrack, Thaís R, Sgrott, Sandro M   +7 more
core   +1 more source

Time course of the interaction between tadalafil and nitrates [PDF]

, 2003
ObjectivesThis study was designed to determine the time course of nitrate interaction with tadalafil, a phosphodiesterase 5 (PDE5) inhibitor with a half-life (t1/2) of 17.5 h.BackgroundThe PDE5 inhibitors augment the blood pressure (BP)-lowering effects ...
Hutter, Adolph M, Emmick, Jeffrey T, Jackson, Graham, Mitchell, Malcolm I, Kloner, Robert A, Denne, Jonathan   +5 more
core   +1 more source

Tadalafil for Treatment of Fetal Growth Restriction: A Review of Experimental and Clinical Studies

Biomedicines
Fetal growth restriction (FGR) is a major concern in perinatal care. Various medications have been proposed as potential treatments for this serious condition. Nonetheless, there is still no definitive treatment. We studied tadalafil, a phosphodiesterase-
Shintaro Maki, Sho Takakura, Makoto Tsuji, Shoichi Magawa, Yuya Tamaishi, Masafumi Nii, Michiko Kaneda, Kenta Yoshida, Kuniaki Toriyabe, Eiji Kondo, Tomoaki Ikeda   +10 more
doaj   +1 more source

Mesothelin as Biomarker and Therapeutic Target for Immunotherapy in Cancer

MedComm, Volume 7, Issue 10, October 2026.
Mesothelin overexpression activate important pathways like nuclear factor k‐light‐chain‐enhancer of activated B cells (NF‐κB) and interleukin‐6 (IL‐6). This in turn causes numerous cancers, such as pancreatic and ovarian cancers. MSLN‐targeting immunotherapies, like monoclonal antibodies, have shown efficacy.
Manoj Kumar Gupta, Ramakrishna Vadde, Ganji Purnachandra Nagaraju   +2 more
wiley   +1 more source

Tadalafil, a Long-Acting Inhibitor of PDE5, Improves Pulmonary Hemodynamics and Survival Rate of Monocrotaline-Induced Pulmonary Artery Hypertension in Rats

Journal of Pharmacological Sciences, 2009
The aim of this study was to assess the effect of tadalafil (0.5, 2.5, and 10 mg/kg per day) on the progression of pulmonary arterial hypertension (PAH) in early treatment and on the survival rate in late treatment on the monocrotaline (MCT)-induced PAH ...
Fusae Sawamura, Masami Kato, Kazuhisa Fujita, Takahiro Nakazawa, Anthony Beardsworth   +4 more
doaj   +1 more source

Recent Updates in Surgical and Non‐Surgical Management of Peyronie's Disease: Implications for Modern Clinical Practice

Trends in Urology &Men's Health, Volume 17, Issue 5, October 2026.
ABSTRACT The management of Peyronie's Disease (PD) remains a clinical challenge to urologists due to its dynamic and heterogeneous nature, variable psychosocial burden, with wide‐ranging treatments, both non‐surgical and surgical. Recent advances in Peyronie's disease (PD) include refined classification systems like PTNM that help facilitate ...
Justin K. Achua, William A. Brown, Beatriz S. Hernandez, Thiago Pardini Furtado, Mohit Khera, Jeffrey C. Morrison   +5 more
wiley   +1 more source

Erectile dysfunction - an update of current practice and future strategies [PDF]

, 2013
Erectile dysfunction (ED) is defined as the inability to achieve and maintain a penile erection adequate for satisfactory sexual intercourse.1 Up to 150 million men worldwide suffer from ED and this figure is likely to double by the year 2025.2 A number
Asif Muneer, Muneer, A, Jas Kalsi, Kalsi, J   +3 more
core   +1 more source

Polyglycolic Acid Polymer Versus Porcine Small Intestine Submucosa Graft After Plaque Incision in Peyronie's Disease: A Comparative Study

Andrology, Volume 14, Issue 7, Page 2160-2165, October 2026.
ABSTRACT Background Peyronie's disease (PD) with severe penile curvature often requires surgical correction through plaque incision and grafting (PIG). Objectives To compare surgical outcomes between polyglycolic acid polymer grafts and porcine small intestinal submucosa (SIS) grafts in patients undergoing PIG for PD.
Renan Trevisan Jost, Leonardo Seligra Lopes, Pedro Caetano Edler Zandoná, Jovânio Fernandes da Rosa, Pedro Fernandes Lessa, Felipe Placco Araujo Glina, Nívio Pascoal Teixeira, Sidney Glina   +7 more
wiley   +1 more source

From Real World Data to Real Impact: A Co‐Medication Framework for Lung Cancer to Advance DDI Assessment and Patient‐Centric Drug Development

Clinical and Translational Science, Volume 19, Issue 10, October 2026.
ABSTRACT Lung cancer predominantly affects older adults who already experience comorbidities and are at increased risk of drug–drug interactions (DDIs) due to polypharmacy. Traditional DDI assessments often do not fully capture complex co‐medication patterns observed in real‐world practice due to the risk of introducing confounding factors.
Mareena Biju, HeeJae Choi, Shilpa Madari, Annie Carlisle, Ashish Sharma, Christina Kunz, Fenglei Huang   +6 more
wiley   +1 more source

Histomorphological Effects of Tadalafil on the Liver of Adult Wistar Rat

Journal of Applied Sciences and Environmental Management
Tadalafil is used to treat erectile dysfunction and improve exercise capacity in people with pulmonary arterial hypertension. It promotes blood circulation to the penis during sexual stimulation, thus facilitating the occurrence of an erection.
P. O. Onyilo, B. O. Samuel
doaj   +1 more source