Results 111 to 120 of about 21,239 (239)

Beyond PD‐1: Mechanisms of Resistance to Checkpoint Blockade in Classical Hodgkin Lymphoma and Next‐Generation Immune Strategies

European Journal of Haematology, Volume 116, Issue 4, Page 357-367, April 2026.
ABSTRACT PD‐1 inhibitors have reshaped the treatment landscape of classical Hodgkin lymphoma, yet a substantial proportion of patients exhibit primary or acquired resistance driven by tumor‐intrinsic alterations, immunosuppressive microenvironmental signals, metabolic constraints, and EBV‐mediated modulation.
Santino Caserta, Enrica Antonia Martino, Mamdouh Skafi, Maria Eugenia Alvaro, Antonella Bruzzese, Nicola Amodio, Eugenio Lucia, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Ernesto Vigna, Fortunato Morabito, Massimo Gentile   +12 more
wiley   +1 more source

Effect of Tadalafil on Prevention of Urethral Stricture after Direct Vision Internal Urethrotomy: A Prospective Cohort Study

Journal of Clinical and Diagnostic Research
Introduction: Urethral stricture recurrence following Direct Vision Internal Urethrotomy (DVIU) remains a significant challenge. Phosphodiesterase type-5 inhibitors (PDE5-Is), such as tadalafil, have been proposed to reduce fibrosis and stricture ...
Shyam Sundar Sarkar, Soumya Mondal, Debansu Sarkar   +2 more
doaj   +1 more source

Enhanced Bioavailability of Tadalafil after Intranasal Administration in Beagle Dogs

Pharmaceutics, 2018
Tadalafil is an oral selective phosphodiesterase type-5 inhibitor with demonstrated efficacy and safety that is used to treat erectile dysfunction. The purpose of this study is to compare the pharmacokinetic properties of tadalafil after conventional ...
Jeong-Soo Kim, Min-Soo Kim, In-hwan Baek
doaj   +1 more source

Cooling down for going up: Could selective ‘brain chilling’ mitigate high‐altitude illness?

Experimental Physiology, EarlyView.
Adnan Haq, Damian M. Bailey
wiley   +1 more source

Association of Abatacept With Lower Mortality Risk Compared to Rituximab in Rheumatoid Arthritis–Associated Interstitial Lung Disease: An Emulated Target Trial

Arthritis &Rheumatology, Volume 78, Issue 3, Page 592-602, March 2026.
Objective The optimal treatment strategy for rheumatoid arthritis–associated interstitial lung disease (RA‐ILD) remains uncertain, and direct comparative data between biologics are limited. This study aimed to evaluate the effectiveness and safety of abatacept compared with rituximab in patients with RA‐ILD.
Po‐Cheng Shih, Shiow‐Ing Wang, James Cheng Chung Wei   +2 more
wiley   +1 more source

Pulmonary arterial hypertension: the burden of disease and impact on quality of life. [PDF]

, 2015
Pulmonary arterial hypertension (PAH) is a debilitating disease that pervades all aspects of a patients daily life. It is also increasingly acknowledged that the burden of PAH extends to older patients and carers.
Delcroix, M, Howard, L
core   +3 more sources

Development and Validation of Tadalafil Determination in Human Plasma by HPLC-MS Method

Разработка и регистрация лекарственных средств, 2019
Introduction. Tadalafil is a drug used to treat erectile dysfunction. For the quantitative determination of tadalafil in human plasma are used methods of high performance liquid chromatography with ultraviolet and tandem mass spectrometric detection ...
D. S. Bogdanova, T. N. Komarov, I. E. Shohin, E. S. Melnikov, O. A. Miskiv, Yu. V. Medvedev   +5 more
doaj   +1 more source

Strategy for the management of antipsychotic-induced sexual dysfunction: a case report description [PDF]

, 2008
Universidade Federal de São Paulo (UNIFESP) Departamento de Psiquiatria Programa de EsquizofreniaUniversidade Federal de São Paulo (UNIFESP) Departamento de PsiquiatriaUNIFESP, Depto. de Psiquiatria Programa de EsquizofreniaUNIFESP, Depto.
Bressan, Rodrigo Affonseca, Dieckmann, Luiz Henrique Junqueira, Lacaz, Fernando Sargo, Mari, Jair de Jesus, Nunes, Luciana Vargas Alves   +4 more
core   +2 more sources

Improvement of peripheral vascular impairment by a phosphodiesterase type 5 inhibitor tadalafil prevents oxaliplatin-induced peripheral neuropathy in mice

Journal of Pharmacological Sciences, 2019
Oxaliplatin, a platinum-based chemotherapeutic drug, frequently induces peripheral neuropathy. Accumulating evidences suggest a possible relationship between peripheral vascular impairment and peripheral neuropathy.
Takashi Ogihara, Takayuki Nakagawa, Maho Hayashi, Madoka Koyanagi, Atsushi Yonezawa, Tomohiro Omura, Shunsaku Nakagawa, Noriaki Kitada, Satoshi Imai, Kazuo Matsubara   +9 more
doaj   +1 more source

Laparoscopic versus open radical prostatectomy in high prostate volume cases: impact on oncological and functional results [PDF]

, 2016
To prospectively compare the laparoscopic versus open approach to RP in cases with high prostate volume and to evaluate a possible diferente impact of prostate ...
Andrea, Fasulo, CATTARINO, SUSANNA, Francesca, Di Quilio, GENTILE, Vincenzo, GENTILUCCI, ALESSANDRO, INNOCENZI, MICHELE, SALCICCIA, STEFANO, SCIARRA, Alessandro, VON HELAND, Magnus   +8 more
core   +1 more source