Results 111 to 120 of about 4,594 (188)

Live cell imaging of X chromosome reactivation during somatic cell reprogramming

Biochemistry and Biophysics Reports, 2018
Generation of induced pluripotent stem cells (iPSCs) with naive pluripotency is important for their applications in regenerative medicine. In female iPSCs, acquisition of naive pluripotency is coupled to X chromosome reactivation (XCR) during somatic ...
Thi Hai Yen Tran, Aya Fukuda, Shiho Aizawa, Phuong Linh Bui, Yohei Hayashi, Ken Nishimura, Koji Hisatake   +6 more
doaj   +1 more source

Ligand-induced global conformational changes in TBP-associated factor 1 (TAF1) tandem bromodomains – a novel strategy for targeting the TAF1 [PDF]

Acta Crystallographica Section A Foundations and Advances, 2021
M. Rezaul Karim, Zachary Shutz, Leixiang Yang, Jiandong Chen, Justin Lopchuk, Ernst Schönbrunn   +5 more
openaire   +1 more source

Reduced neuron-specific expression of the TAF1 gene is associated with X-linked dystonia-Parkinsonism [PDF]

, 2007
X-linked dystonia-parkinsonism (XDP) is a movement disorder endemic to the Philippines. The disease locus, DYT3, has been mapped to Xq13.1. In a search for the causative gene, we performed genomic sequencing analysis, followed by expression analysis of ...
Tabuena, Ma. Daisy, Tomizawa, Maiko, Matsumoto, Shinnichi, Tooyama, Ikuo, Kaji, Ryuji, Ando, Satoshi, Maranon, Elma, Makino, Satoshi, Dantes, Marita, Ogasawara, Kazumasa, Goto, Satoshi, Lee, Lillian V., Nishimura, Masataka, Tamiya, Gen, Yasuno, Katsuhito, Akatsu, Hiroyasu   +15 more
core   +1 more source

The bromodomain-containing protein tBRD-1 is specifically expressed in spermatocytes and is essential for male fertility

Biology Open, 2012
Summary By a conserved cellular differentiation process, spermatogenesis leads to formation of haploid sperm for successful reproduction. In Drosophila and in mammals, post-meiotic spermatid differentiation depends on several translationally repressed ...
Katja Leser, Stephan Awe, Bridlin Barckmann, Renate Renkawitz-Pohl, Christina Rathke   +4 more
doaj   +1 more source

Effort to differentiate essential tremor plus and dystonic tremor using whole exome sequencing: an exploratory study

Dystonia
BackgroundThe clinical differentiation between essential tremor plus (ETP) and dystonic tremor (DT) is challenging. This study aimed at the genetic diagnosis of ETP and DT.MethodsWhole exome sequencing was performed on 50 probands (ETP = 25; DT = 25) and
Sanjay Pandey, Sanjay Pandey, Navneesh Yadav, Shreya Dinesh, Shreya Dinesh, Chandra Shekhar Rawat, Chandra Shekhar Rawat, B. K. Thelma   +7 more
doaj   +1 more source

TAF1 Regulation of Gene Expression: Genome-Wide Localization and Transcription Profiling [PDF]

, 2009
The general transcription factor II D (TFIID) nucleates the assembly of general transcription factors (GTF) and RNA polymerase II at the promoters to form the pre-initiation complex (PIC).
Tsai, Pei-Fang
core   +1 more source

High-resolution structure of TBP with TAF1 reveals anchoring patterns in transcriptional regulation

, 2013
The general transcription factor TFIID provides a regulatory platform for transcription initiation. Here we present the crystal structure (1.97 angstrom) and NMR analysis of yeast TAF1 N-terminal domains TAND1 and TAND2 bound to yeast TBP, together with ...
Cecilia Andresen, Marina I Siponen, Anandapadmanaban, Madhanagopal,, Ikura, Mitsuhiko,, Yoshifumi Ohyama, Madhanagopal Anandapadamanaban, Tetsuro Kokubo, Lundström, Patrik,, Patrik Lundström, Mitsuhiko Ikura, Helander, Sara,, Andrésen, Cecilia,, Maria Sunnerhagen, Siponen, Marina I.,, Sunnerhagen, Maria,, Moche, Martin,, Sara Helander, Martin Moche, Kokubo, Tetsuro,, Ohyama, Yoshifumi,, Anandapadamanaban, M, Moche, M,, Lundstrom, P, Siponen, MI, Helander, S, Sunnerhagen, M, Andresen, C, Ohyama, Y, Kokubo, T, Ikura, M   +29 more
core   +1 more source

TAF1 Gene [PDF]

, 2020
openaire   +1 more source

Neuronal-specific microexon splicing of TAF1 mRNA is directly regulated by SRRM4/nSR100

, 2019
Neuronal microexons represent the most highly conserved class of alternative splicing events and their timed expression shapes neuronal biology, including neuronal commitment and differentiation.
Jill R. Crittenden (7437215), Frederik M.A. Van Schaik (7437194), Lisa Lehmann (6949541), Manuel Irimia (52134), Ann M. Graybiel (7437209), Mercedes M. Ondik (7437197), Benjamin J. Blencowe (7437212), Menno P. Creyghton (7437206), Oliver Schilling (520734), Martin L. Biniossek (402513), Nadja Stöffler (7437191), Marit W. Vermunt (7437203), Simona Capponi (7437188), Thomas Reinheckel (207744), H. Th. Marc Timmers (7437218), Julia Mitschke (7437200)   +15 more
core   +1 more source

TAF1 wt Allele [PDF]

, 2020
openaire   +1 more source