Results 101 to 110 of about 4,594 (188)
Zinc knuckle of TAF1 is a DNA binding module critical for TFIID promoter occupancy
, 2018 The general transcription factor IID (TFIID) is the first component of the preinitiation complex (PIC) to bind the core promoter of RNA polymerase II transcribed genes.
Hui Wang +4 more
core +1 more source
Arabidopsis TAF1 is an MRE11-interacting protein required for resistance to genotoxic stress and viability of the male gametophyte [PDF]
, 2015 Repair of DNA double strand breaks (DSBs) by recombination pathways is essential for plant growth and fertility. The recombination endonuclease MRE11 plays important roles in sensing and repair of DNA DSBs. Here we demonstrate protein interaction between
Drury, GE +3 more
core +1 more source
Investigations into the Role of TAF1-mediated Phosphorylation in Gene Regulation [PDF]
, 2012 In response to cellular stresses, the transcription factor p53, a tumor suppressor, controls cell cycle arrest, DNA repair, or senescence by modulating the expression of target genes.
Gadd, Brian James
core +1 more source
Transcriptional Regulation by TAF1 Kinase [PDF]
, 2020 Transcription of protein coding genes and some non-coding RNAs relies on RNA polymerase II (pol II). Positioning the polymerase at the correct location at the start of a gene is aided by a series of general transcription factors (GTFs): TFIIA, B, D, E, F,
Benedict, Thomas
core +1 more source
eLife, 2017 General transcription factor TFIID is a key component of RNA polymerase II transcription initiation. Human TFIID is a megadalton-sized complex comprising TATA-binding protein (TBP) and 13 TBP-associated factors (TAFs).
Kapil Gupta +20 more
doaj +1 more source
Regulatory role of transcription factors TAF1 and TAF7 in cyclin gene expression [PDF]
, 2012 Thesis (Ph.D.)--University of Washington, 2012The largest transcription factor IID (TFIID) subunit, TBP associated factor 1 (TAF1) possesses protein kinase and histone acetyltransferase (HAT) activities.
Kloet, Susan
core
Vulnerability of Purkinje Cells Generated from Spinocerebellar Ataxia Type 6 Patient-Derived iPSCs
Cell Reports, 2016 Spinocerebellar ataxia type 6 (SCA6) is a dominantly inherited neurodegenerative disease characterized by loss of Purkinje cells in the cerebellum. SCA6 is caused by CAG trinucleotide repeat expansion in CACNA1A, which encodes Cav2.1, α1A subunit of P/Q ...
Yoshihito Ishida +6 more
doaj +1 more source
Pediatric lung adenocarcinoma presenting with brain metastasis: a case report
Journal of Medical Case Reports, 2018 Background Diagnosis and treatment of primary lung adenocarcinoma in children remains challenging given its rarity. Here we highlight the clinical history, pathological evaluation, genomic findings, and management of a very young patient with metastatic ...
Lucia De Martino +9 more
doaj +1 more source
Efficiency strategy for mapping female fertility QTL in wheat (Triticum aestivum L.)
浙江大学学报. 农业与生命科学版, 2009 To map female fertility loci efficiently in wheat, selective phenotyping and linkage disequilibrium (LD) were adopted as a combined strategy to select candidate markers.
DOU Bing-de +4 more
doaj +1 more source
Frontiers in Immunology, 2018 The potent proinflammatory cytokine interleukin (IL)-1 triggers gene expression through the NF-κB signaling pathway. Here, we investigated the cofactor requirements of strongly regulated IL-1 target genes whose expression is impaired in p65 NF-κB ...
Johanna Meier-Soelch +7 more
doaj +1 more source