Results 81 to 90 of about 3,740 (175)

Genome-Wide Analysis of Transcriptional Regulation via TAF1 Kinase [PDF]

, 2017
Gene regulation is a complex mechanism and our knowledge of molecular pathways remains limited. In particular, current research examining transcriptional regulation emphasizes events that precede the initiation of transcription.
Maxham, Lily Ann
core  

Identification of dual histone modification-binding protein interaction by combining mass spectrometry and isothermal titration calorimetric analysis

Journal of Advanced Research, 2020
Histone posttranslational modifications (HPTMs) play important roles in eukaryotic transcriptional regulation. Recently, it has been suggested that combinatorial modification codes that comprise two or more HPTMs can recruit readers of HPTMs, performing ...
Pu Chen, Zhenchang Guo, Cong Chen, Shanshan Tian, Xue Bai, Guijin Zhai, Zhenyi Ma, Huiyuan Wu, Kai Zhang   +8 more
doaj   +1 more source

Zinc knuckle of TAF1 is a DNA binding module critical for TFIID promoter occupancy

, 2018
The general transcription factor IID (TFIID) is the first component of the preinitiation complex (PIC) to bind the core promoter of RNA polymerase II transcribed genes.
Hui Wang, Ning Zheng, Edith H. Wang, Thomas R. Hinds, Elizabeth C. Curran   +4 more
core   +1 more source

Pediatric T‐Lymphoblastic Leukemia With Aberrant B‐Cell Marker Expression: A Potential Role for Targeted Therapy

eJHaem, Volume 6, Issue 6, December 2025.
ABSTRACT Background Expression of B‐cell antigens is rare in T‐lymphoblastic leukemia/lymphoma (T‐LBLL), and the significance is uncertain. Objective and Methods We present a pediatric case of acute leukemia characterized by the expression of T‐cell markers and CD19, as determined by multicolor flow cytometry (MFC).
Mahsa Khanlari, Wei Wang, Paul E. Mead, Laura Key, Peixin Liu, Beenu Thakral, Patrick R. Blackburn, Jeffery M. Klco, Raul Ribeiro, Supriya Sarvode   +9 more
wiley   +1 more source

Vulnerability of Purkinje Cells Generated from Spinocerebellar Ataxia Type 6 Patient-Derived iPSCs

Cell Reports, 2016
Spinocerebellar ataxia type 6 (SCA6) is a dominantly inherited neurodegenerative disease characterized by loss of Purkinje cells in the cerebellum. SCA6 is caused by CAG trinucleotide repeat expansion in CACNA1A, which encodes Cav2.1, α1A subunit of P/Q ...
Yoshihito Ishida, Hideshi Kawakami, Hiroyuki Kitajima, Ayaka Nishiyama, Yoshiki Sasai, Haruhisa Inoue, Keiko Muguruma   +6 more
doaj   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

Mining Alzheimer's Interactomes, Macromolecular Complexes and Pathways for Drug Discovery

PROTEOMICS, Volume 25, Issue 21-22, Page 102-150, November 2025.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder that leads to dementia. Many cases are diagnosed annually and there is no currently available cure. Understanding the underlying disease biology of AD through the study of molecular networks, particularly by mapping clinical variants to tissue‐specific interactomes and ...
Kalpana Panneerselvam, Krishna Kumar Tiwari, Luana Licata, Simona Panni, Sylvie Ricard‐Blum, Sucharitha Balu, Susie Huget, Juan Jose Medina Reyes, Eliot Ragueneau, Livia Perfetto, Birgit Meldal, Sandra Orchard, Henning Hermjakob   +12 more
wiley   +1 more source

RNAi-Based Identification of Gene-Specific Nuclear Cofactor Networks Regulating Interleukin-1 Target Genes

Frontiers in Immunology, 2018
The potent proinflammatory cytokine interleukin (IL)-1 triggers gene expression through the NF-κB signaling pathway. Here, we investigated the cofactor requirements of strongly regulated IL-1 target genes whose expression is impaired in p65 NF-κB ...
Johanna Meier-Soelch, Liane Jurida, Axel Weber, Doris Newel, Johnny Kim, Thomas Braun, M. Lienhard Schmitz, Michael Kracht   +7 more
doaj   +1 more source

TAF1, associated with intellectual disability in humans, is essential for embryogenesis and regulates neurodevelopmental processes in zebrafish

, 2019
The TATA-box binding protein associated factor 1 (TAF1) protein is a key unit of the transcription factor II D complex that serves a vital function during transcription initiation.
Allalou, Amin, Ledin, Johan,, Bondeson, Marie-Louise,, Wilbe, Maria, Johansson, J., Gudmundsson, Sanna, Kalscheuer, V., Ledin, J., Filipek-Górniok, B., Johansson, Josefin,, Gudmundsson, Sanna,, Johansson, Josefin, Kalscheuer, Vera M.,, Gudmundsson, S., Molin, Anna-Maja,, Annerén, Göran,, Ekvall, Sara, Allalou, A., Ekvall, S., Gylje, H., Gorniok, Beata Filipek,, Molin, Anna-Maja, Ledin, Johan, Kalscheuer, Vera M., Allalou, Amin,, Gylje, Hans, Bondeson, M., Wilbe, M., Annerén, G., Wilbe, Maria,, Gylje, Hans,, Ekvall, Sara,, Gorniok, Beata Filipek, Bondeson, Marie-Louise, Molin, A., Annerén, Göran   +35 more
core   +1 more source

Pediatric lung adenocarcinoma presenting with brain metastasis: a case report

Journal of Medical Case Reports, 2018
Background Diagnosis and treatment of primary lung adenocarcinoma in children remains challenging given its rarity. Here we highlight the clinical history, pathological evaluation, genomic findings, and management of a very young patient with metastatic ...
Lucia De Martino, Maria Elena Errico, Serena Ruotolo, Daniele Cascone, Stefano Chiaravalli, Paola Collini, Andrea Ferrari, Paolo Muto, Giuseppe Cinalli, Lucia Quaglietta   +9 more
doaj   +1 more source