Results 61 to 70 of about 4,594 (188)

The Cytoplasmic Domain of Xenopus NF-Protocadherin Interacts with TAF1/Set [PDF]

Developmental Cell, 2003
Protocadherins are members of the cadherin superfamily of cell adhesion molecules proposed to play important roles in early development, but whose mechanisms of action are largely unknown. We examined the function of NF-protocadherin (NFPC), a novel cell adhesion molecule essential for the histogenesis of the embryonic ectoderm in Xenopus, and ...
Heggem, Mike A, Bradley, Roger S
openaire   +2 more sources

TAF1, associated with intellectual disability in humans, is essential for embryogenesis and regulates neurodevelopmental processes in zebrafish [PDF]

, 2019
The TATA-box binding protein associated factor 1 (TAF1) protein is a key unit of the transcription factor II D complex that serves a vital function during transcription initiation.
Allalou, Amin, Ledin, Johan,, Bondeson, Marie-Louise,, Wilbe, Maria, Johansson, J., Gudmundsson, Sanna, Kalscheuer, V., Ledin, J., Filipek-Górniok, B., Johansson, Josefin,, Gudmundsson, Sanna,, Johansson, Josefin, Kalscheuer, Vera M.,, Gudmundsson, S., Molin, Anna-Maja,, Annerén, Göran,, Ekvall, Sara, Allalou, A., Ekvall, S., Gylje, H., Gorniok, Beata Filipek,, Molin, Anna-Maja, Ledin, Johan, Kalscheuer, Vera M., Allalou, Amin,, Gylje, Hans, Bondeson, M., Wilbe, M., Annerén, G., Wilbe, Maria,, Gylje, Hans,, Ekvall, Sara,, Gorniok, Beata Filipek, Bondeson, Marie-Louise, Molin, A., Annerén, Göran   +35 more
core   +1 more source

Differential dependencies of human RNA polymerase II promoters on TBP, TAF1, TFIIB and XPB

Nucleic Acids Research, 2022
The effects of rapid acute depletion of components of RNA polymerase II (Pol II) general transcription factors (GTFs) that are thought to be critical for formation of preinitiation complexes (PICs) and initiation in vitro were quantified in HAP1 cells ...
Juan F. Santana, Geoffrey S. Collins, Mrutyunjaya Parida, D. Luse, D. Price   +4 more
semanticscholar   +1 more source

The expression of the transcription factor TAF1 is modified by the HPV16 E2 protein

Acta virologica, 2020
High-risk human papillomaviruses (e.g., HPV16 and 18) are associated with cervical cancer occurrence and development. The early viral gene E2 encodes a protein involved in several key processes in HPV biology, such as replication, genome segregation, and viral gene transcription.
J, Sánchez-Ramos, G, Pozo-Molina, E, Garrido   +2 more
openaire   +3 more sources

Taf1 Regulates Pax3 Protein by Monoubiquitination in Skeletal Muscle Progenitors [PDF]

Molecular Cell, 2010
Pax3 plays critical roles during developmental and postnatal myogenesis. We have previously shown that levels of Pax3 protein are regulated by monoubiquitination and proteasomal degradation during postnatal myogenesis, but none of the key regulators of the monoubiquitination process were known.
S. C. Boutet, Biressi, Stefano Augusto Maria, K. Iori, V. Natu, T. A. Rando   +4 more
openaire   +2 more sources

Eyes Toward the Clinic: Selective Inhibition and Degradation Approaches to Bromodomain-Containing Proteins. [PDF]

Chembiochem
The function of bromodomain‐containing proteins in regulating gene transcription is reviewed here, including the development of chemical probes and targeted protein degradation modalities (e.g., PROTACs). This extends to clinical efforts targeting the BET bromodomain‐containing proteins. Challenges of selectivity, future prospects, and the differential
Scholtz CR, Pomerantz WCK.
europepmc   +2 more sources

TAF1 as the Most Plausible Disease Gene for XDP/DYT3 [PDF]

The American Journal of Human Genetics, 2007
To the Editor: We address the concerns of Dr. Muller and his colleagues1(in this issue) regarding our recent article in the Journal.2 Previously, Muller et al. reported that five disease-specific single-nucleotide changes (DSCs) in a “multiple transcript system” (MTS) were associated with XDP (MIM #314250).3 Our article was the first to report TAF1 ...
Tamiya, Gen, Makino, Satoshi, Kaji, Ryuji   +2 more
openaire   +1 more source

Functional analysis of N-TAF1, the disease causative gene of X-linked recessive dystonia-parkinsonism [PDF]

, 2010
科学研究費補助金研究成果報告書研究種目: 若手研究(B)研究期間: 2008～2009課題番号: 20790266研究代表者: 牧野 悟士（滋賀医科大学・分子神経科学研究センター・非常勤研究員）伴性劣性ジストニアパーキンソニズムの原因遺伝子TAF1の神経細胞特異的なアイソフォームに関して、神経細胞における役割を明らかにすることを目的として、マウス胚発生期におけるN-TAF1の発現パターン解析と、N-TAF1およびTAF1タンパク質を強制発現させた培養細胞株における細胞化学的な解析を行った。その結果、N ...
牧野,　悟士, MAKINO, Satoshi
core  

Neonatal‐onset developmental and epileptic encephalopathy: High genetic yield and long‐term outcomes in a multicenter southern European cohort

Epilepsia Open, EarlyView.
Abstract Objective To determine the genetic diagnostic yield, characterize the clinical and genetic landscape, and evaluate long‐term epilepsy, neurodevelopmental, and survival outcomes in a strictly defined cohort of neonatal‐onset developmental and epileptic encephalopathy (DEE).
Júlia Sala‐Coromina, Anna Marcé‐Grau, Gianluca D'Onofrio, Antonella Riva, Roser Pons, Elisabeta Kollia E, Miquel Raspall‐Chaure, Eduardo López‐Laso, Javier López‐Pisón, Edgard Verdura, Agatha Schlüter, Dolors Casellas‐Vidal, Maria Camós‐Carreras, Michele Iacomino, Alberto Spalice, Pasquale Parisi, Alejandro Martínez de la Ossa‐Vela, Mónica Vicente‐Rasoamalala, Aurora Pujol, Vincenzo Salpietro, Pasquale Striano, Alfons Macaya   +21 more
wiley   +1 more source

TAF1 Variants Are Associated with Dysmorphic Features, Intellectual Disability, and Neurological Manifestations [PDF]

The American Journal of Human Genetics, 2015
We describe an X-linked genetic syndrome associated with mutations in TAF1 and manifesting with global developmental delay, intellectual disability (ID), characteristic facial dysmorphology, generalized hypotonia, and variable neurologic features, all in male individuals.
O'Rawe, J.A., Wu, Y.Y., Dorfel, M.J., Rope, A.F., Au, P.Y.B., Parboosingh, J.S., Moon, S., Kousi, M., Kosma, K., Smith, C.S., Tzetis, M., Schuette, J.L., Hufnagel, R.B., Prada, C.E., Martinez, F., Orellana, C., Crain, J., Caro-Llopis, A., Oltra, S., Monfort, S., Jimenez-Barron, L.T., Swensen, J., Ellingwood, S., Smith, R., Fang, H., Ospina, S., Stegmann, S., Hollander, N. den, Mittelman, D., Highnam, G., Robison, R., Yang, E., Faivre, L., Roubertie, A., Riviere, J.B., Monaghan, K.G., Wang, K., Davis, E.E., Katsanis, N., Kalscheuer, V.M., Wang, E.H., Metcalfe, K., Kleefstra, T., Innes, A.M., Kitsiou-Tzeli, S., Rosello, M., Keegan, C.E., Lyon, G.J.   +47 more
openaire   +9 more sources