Results 51 to 60 of about 4,594 (188)

Yeast Bromodomain Factor 1 and Its Human Homolog TAF1 Play Conserved Roles in Promoting Homologous Recombination

Advanced Science, 2021
Histone acetylation is a key histone post‐translational modification that shapes chromatin structure, dynamics, and function. Bromodomain (BRD) proteins, the readers of acetyl‐lysines, are located in the center of the histone acetylation‐signaling ...
Haoyang Peng, Simin Zhang, Yihan Peng, Shuangyi Zhu, Xin Zhao, Xiaocong Zhao, Shuangshuang Yang, Guangxue Liu, Yang Dong, Xiaoli Gan, Qing Li, Xinghua Zhang, Huadong Pei, Xuefeng Chen   +13 more
doaj   +1 more source

Genome-wide Transcriptional Dependence on TAF1 Functional Domains [PDF]

Journal of Biological Chemistry, 2006
Transcription factor IID (TFIID) plays a central role in regulating the expression of most eukaryotic genes. Of the 14 TBP-associated factor (TAF) subunits that compose TFIID, TAF1 is one of the largest and most functionally diverse. Yeast TAF1 can be divided into four regions including a putative histone acetyltransferase domain and TBP, TAF, and ...
Jordan D, Irvin, B Franklin, Pugh
openaire   +2 more sources

DNA Binding Properties of TAF1 Isoforms with Two AT-hooks [PDF]

Journal of Biological Chemistry, 2006
TATA-binding protein-associated factor 1 (TAF1) is an essential component of the general transcription factor IID (TFIID), which nucleates assembly of the preinitiation complex for transcription by RNA polymerase II. TATA-binding protein and TAF1.TAF2 heterodimers are the only components of TFIID shown to bind specific DNA sequences (the TATA box and ...
Chad E, Metcalf, David A, Wassarman
openaire   +2 more sources

X-Linked Dystonia Parkinsonism: Clinical Phenotype, Genetics and Therapeutics [PDF]

Journal of Movement Disorders, 2010
The clinical phenotype of X-Linked Dystonia Parkinsonism (XDP) is typically one that involves a Filipino adult male whose ancestry is mostly traced in the Philippine island of Panay.
Raymond L. Rosales
doaj   +1 more source

Systematic assessment of the mouse TATA-box binding protein-associated factor 1 locus reveals novel messenger RNA isoforms and differential protein distribution across brain regions [PDF]

Royal Society Open Science
TATA-box binding protein-associated factor 1 (TAF1) is the largest component of transcription factor IID, a fundamental multi-protein complex for RNA polymerase II-mediated transcription.
Peihang Li, Karen Cleverley, Elisa M. Crombie, Jan Bieschke, Elizabeth M. C. Fisher, Anna-Leigh Brown   +5 more
doaj   +1 more source

Differential Water Networks Guide Selectivity Optimization of a Cell Active BPTF Inhibitor in Neuroblastoma

Angewandte Chemie, Volume 138, Issue 44, 26 October 2026.
BZ2 is a second‐generation Bromodomain PHD finger Transcription Factor (BPTF) inhibitor with improved selectivity over Class I and Class IV BRD off‐targets identified in our previously reported inhibitor, BZ1. Structural analyses reveal that water network engagement is key to this selectivity.
Kesavan Babu, Chun‐Ju Tsou, Sourav Das, Liying Fan, Anasuya Pal, Molly Sneddon, Timothy R. Stachowski, Priyanka Samanta, Stanley Nithianantham, Caroline Buchholz, Shi Zhang, Xiang Fu, Rahul S. Kathayat, Wenwei Lin, Yongtao Li, Lei Yang, Taosheng Chen, Marcus Fischer, Anang A. Shelat, William C. K. Pomerantz   +19 more
wiley   +2 more sources

Three novel downstream promoter elements regulate MHC class I promoter activity in mammalian cells. [PDF]

PLoS ONE, 2010
MHC CLASS I TRANSCRIPTION IS REGULATED BY TWO DISTINCT TYPES OF REGULATORY PATHWAYS: 1) tissue-specific pathways that establish constitutive levels of expression within a given tissue and 2) dynamically modulated pathways that increase or decrease ...
Namhoon Lee, Shankar S Iyer, Jie Mu, Jocelyn D Weissman, Anat Ohali, T Kevin Howcroft, Brian A Lewis, Dinah S Singer   +7 more
doaj   +1 more source

Taf1 N-terminal domain 2 (TAND2) of TFIID promotes formation of stable and mobile unstable TBP-TATA complexes.

Gene, 2023
In eukaryotes, TATA-binding protein (TBP) occupancy of the core promoter globally correlates with transcriptional activity of class II genes. Elucidating how TBP is delivered to the TATA box or TATA-like element is crucial to understand the mechanisms of
S. Miyasaka, Ryota Kitada, T. Kokubo
semanticscholar   +1 more source

TAF1 bromodomain inhibition as a candidate epigenetic driver of congenital heart disease.

Biochimica et Biophysica Acta - Molecular Basis of Disease, 2023
Heart formation requires transcriptional regulators that underlie congenital anomalies and the fetal gene program activated during heart failure. Attributing the effects of congenital heart disease (CHD) missense variants to disruption of specific ...
R. Leigh, Mika J. Välimäki, Bogac L. Kaynak, H. Ruskoaho   +3 more
semanticscholar   +1 more source

Extracellular vesicle‐mediated delivery of circDYM alleviates CUS‐induced depressive‐like behaviours

Journal of Extracellular Vesicles, 2022
Major depressive disorder (MDD) is the most prevalent psychiatric disorder worldwide and severely limits psychosocial function and quality of life, but no effective medication is currently available.
Xiaoyu Yu, Ying Bai, Bing Han, Minzi Ju, Tianci Tang, Ling Shen, Mingyue Li, Li Yang, Zhao Zhang, Guoku Hu, Jie Chao, Yuan Zhang, Honghong Yao   +12 more
doaj   +1 more source