Results 41 to 50 of about 3,740 (175)

Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains [PDF]

Journal of Medicinal Chemistry, 2017
Bromodomains (BD) are readers of lysine acetylation marks present in numerous proteins associated with chromatin. Here we describe a dual inhibitor of the bromodomain and PHD finger (BRPF) family member BRPF2 and the TATA box binding protein-associated factors TAF1 and TAF1L.
Bouche, Lea; Christ, Clara D.; Siegel, Stephan; Fernandez-Montalvan, Amaury E.; Holton, Simon J.; Fedorov, Oleg; ter Laak, Antonius; Sugawara, Tatsuo; Stoeckigt, Detlef; Tallant, Cynthia; Bennett, James; Monteiro, Octovia; Diaz-Saez, Laura; Siejka, Paulina; Meier, Julia; Puetter, Vera; Weiske, Joerg; Mueller, Susanne; Huber, Kilian V. M.; Hartung, Ingo V.; Haendler, Bernard   +21 more
openaire   +2 more sources

Dissection of TAF1 neuronal splicing and implications for neurodegeneration in X-linked dystonia-parkinsonism

, 2021
: X-linked dystonia-parkinsonism (XDP) is a monogenic neurodegenerative disorder of the basal ganglia, which presents as a combination of hyperkinetic movements and parkinsonian features.
Ang, Mark A., Penney, Ellen B., Legarda, G. Paul, Nizamuddin, Sheikh, Capponi, Simona, De Rijk, Peter, Fernandez-Cerado, Cara, Creyghton, Menno P., Bragg, D. Cristopher, Gruetz, Karen, Castelijns, Bas, Munoz, Edwin L., Vermunt, Marit W., Stoeffler, Nadja, Klein, Christine, Velasco-Andrada, M. Salvie, Timmers, H.T. Marc, Diesta, Cid Czarina E.   +17 more
core   +2 more sources

Mechanistic insights into DNA binding by BD1 of the TAF1 tandem bromodomain module. [PDF]

Biochem J
Transcription initiation factor TFIID subunit 1 (TAF1) is a pivotal component of the TFIID complex, critical for RNA polymerase II-mediated transcription initiation. However, the molecular basis by which TAF1 recognizes and associates with chromatin remains incompletely understood.
Yadav Y, Chyne P, Sudhamalla B.
europepmc   +3 more sources

Three novel downstream promoter elements regulate MHC class I promoter activity in mammalian cells. [PDF]

PLoS ONE, 2010
MHC CLASS I TRANSCRIPTION IS REGULATED BY TWO DISTINCT TYPES OF REGULATORY PATHWAYS: 1) tissue-specific pathways that establish constitutive levels of expression within a given tissue and 2) dynamically modulated pathways that increase or decrease ...
Namhoon Lee, Shankar S Iyer, Jie Mu, Jocelyn D Weissman, Anat Ohali, T Kevin Howcroft, Brian A Lewis, Dinah S Singer   +7 more
doaj   +1 more source

Extracellular vesicle‐mediated delivery of circDYM alleviates CUS‐induced depressive‐like behaviours

Journal of Extracellular Vesicles, 2022
Major depressive disorder (MDD) is the most prevalent psychiatric disorder worldwide and severely limits psychosocial function and quality of life, but no effective medication is currently available.
Xiaoyu Yu, Ying Bai, Bing Han, Minzi Ju, Tianci Tang, Ling Shen, Mingyue Li, Li Yang, Zhao Zhang, Guoku Hu, Jie Chao, Yuan Zhang, Honghong Yao   +12 more
doaj   +1 more source

TAF1 as the Most Plausible Disease Gene for XDP/DYT3 [PDF]

The American Journal of Human Genetics, 2007
To the Editor: We address the concerns of Dr. Muller and his colleagues1(in this issue) regarding our recent article in the Journal.2 Previously, Muller et al. reported that five disease-specific single-nucleotide changes (DSCs) in a “multiple transcript system” (MTS) were associated with XDP (MIM #314250).3 Our article was the first to report TAF1 ...
Tamiya, Gen, Makino, Satoshi, Kaji, Ryuji   +2 more
openaire   +3 more sources

Taf1 Regulates Pax3 Protein by Monoubiquitination in Skeletal Muscle Progenitors [PDF]

Molecular Cell, 2010
Pax3 plays critical roles during developmental and postnatal myogenesis. We have previously shown that levels of Pax3 protein are regulated by monoubiquitination and proteasomal degradation during postnatal myogenesis, but none of the key regulators of the monoubiquitination process were known.
S. C. Boutet, Biressi, Stefano Augusto Maria, K. Iori, V. Natu, T. A. Rando   +4 more
openaire   +2 more sources

TAF1 Variants Are Associated with Dysmorphic Features, Intellectual Disability, and Neurological Manifestations [PDF]

The American Journal of Human Genetics, 2015
We describe an X-linked genetic syndrome associated with mutations in TAF1 and manifesting with global developmental delay, intellectual disability (ID), characteristic facial dysmorphology, generalized hypotonia, and variable neurologic features, all in male individuals.
O'Rawe, J.A., Wu, Y.Y., Dorfel, M.J., Rope, A.F., Au, P.Y.B., Parboosingh, J.S., Moon, S., Kousi, M., Kosma, K., Smith, C.S., Tzetis, M., Schuette, J.L., Hufnagel, R.B., Prada, C.E., Martinez, F., Orellana, C., Crain, J., Caro-Llopis, A., Oltra, S., Monfort, S., Jimenez-Barron, L.T., Swensen, J., Ellingwood, S., Smith, R., Fang, H., Ospina, S., Stegmann, S., Hollander, N. den, Mittelman, D., Highnam, G., Robison, R., Yang, E., Faivre, L., Roubertie, A., Riviere, J.B., Monaghan, K.G., Wang, K., Davis, E.E., Katsanis, N., Kalscheuer, V.M., Wang, E.H., Metcalfe, K., Kleefstra, T., Innes, A.M., Kitsiou-Tzeli, S., Rosello, M., Keegan, C.E., Lyon, G.J.   +47 more
openaire   +9 more sources

The synergistic interaction landscape of chromatin regulators reveals their epigenetic regulation mechanisms across five cancer cell lines

Computational and Structural Biotechnology Journal, 2022
Chromatin regulators (CRs) regulate the gene transcription process through combinatorial patterns, which currently remain obscure for pan-cancer. This study identified the interaction of CRs and constructed CR-CR interaction networks across five tumor ...
Meng Cao, Liqiang Wang, Dahua Xu, Xiaoman Bi, Shengnan Guo, Zhizhou Xu, Liyang Chen, Dehua Zheng, Peihu Li, Jiankai Xu, Shaojiang Zheng, Hong Wang, Bo Wang, Jianping Lu, Kongning Li   +14 more
doaj   +1 more source

Transcriptional Regulation by TAF1 Kinase [PDF]

, 2020
Transcription of protein coding genes and some non-coding RNAs relies on RNA polymerase II (pol II). Positioning the polymerase at the correct location at the start of a gene is aided by a series of general transcription factors (GTFs): TFIIA, B, D, E, F,
Benedict, Thomas
core