Results 21 to 30 of about 3,740 (175)

NSP7 Molecular Degrader Attenuates Coronaviral Infection Through the β‐TrCP1/FBXO5 Axis [PDF]

Advanced Science
NSP7 (Non‐Structural Protein 7) of SARS‐CoV‐2 is a crucial component for viral replication and transcription. In this study, it is revealed that the host E3 ubiquitin ligase FBXO5 suppresses viral replication by mediating NSP7 lysine‐48‐linked ...
Yao Tong, Travis B. Lear, Ferhan Tuncer, John J. Villandre, Áine N. Boudreau, Bo Lin, Irene Alfaras, Jason R. Kennerdell, Daniel P. Camarco, Mads B. Larsen, Yun Hua, Yanwen Chen, Meigin E. Chandler, Ricardo Pineda, Simon M. Barratt‐Boyes, John W. Evankovich, Toren Finkel, Yuan Liu, Bill B. Chen   +18 more
doaj   +2 more sources

LncR-GAS5 decrease in adenine phosphoribosyltransferase expresssion via binding TAF1 to increase kidney damage created by CIH [PDF]

Heliyon
Objective: Chronic kidney disease (CKD) related to obstructive sleep apnea-hypopnea syndrome (OSAHS) mainly results from chronic intermittent hypoxia (CIH)-induced renal injury.
Wei Liu, Wukaiyang Liang, CunTai Zhang, Huiguo Liu, Hai Li, Lun Zhou, Ling Zhou   +6 more
doaj   +2 more sources

Activation of CISD2 as a protective strategy against doxorubicin-induced cardiotoxicity [PDF]

Redox Biology
Background: Cardiotoxicity of doxorubicin, a chemotherapy medication, remains the most dangerous side effect. CISD2 plays a critical role during cardiac aging.
Yi-Ju Chou, Chi-Hsiao Yeh, Chian-Feng Chen, Chi-Jen Lo, Jian-Hsin Yang, Wen-Tai Chiu, Cheng-Heng Kao, Tsai-Yu Tzeng, Zhao-Qing Shen, Chien-Yi Tung, Chung-Kuang Lu, Mei-Ling Cheng, Patrick C.H. Hsieh, Shu-Ling Fu, Ting-Fen Tsai   +14 more
doaj   +2 more sources

Missense variants in TAF1 and developmental phenotypes: challenges of determining pathogenicity. [PDF]

Human Mutation, 2019
peer reviewedWe recently described a new neurodevelopmental syndrome (TAF1/MRXS33 intellectual disability syndrome) (MIM# 300966) caused by pathogenic variants involving the X-linked gene TAF1, which participates in RNA polymerase II transcription.
Zhao, Mengge, Palmer, Elizabeth E., Alexander, Nora, Leon, Eyby, Lunke, Sebastian, Walsh, Laurence E., Dreyer, Lauren, Baynam, Gareth, Li, Quan, Rope, Alan F., Kline, Antonie D., de Munnik, Sonja A., Capponi, Simona, Piatek, Stefan G., Fassi, Emily, Ewans, Lisa, Buckley, Michael F., Lukusa, Prosper, Soares, Gabriela, Lupski, James R., Mallawaarachchi, Amali, Timmers, T. Marc, Devriendt, Koenraad, Mallawaarachchi, Amalia, Guillen Sacoto, Maria J., Vermeesch, Joris, Posey, Jennifer E., Stefan, Piatek G., Weng, Chunhua, Vogt, Julie, Agrawal, Pankaj B., Murray, Lucinda, Douglas, Ganka, Sacoto, Maria J. Guillen, Worgan, Lisa, Goncalves, Ana R., Mohammed, Shehla, Rope, Alan, Wang, Kai, Timmers, H.T. Marc, Stark, Zornitza, Moutton, Sebastien, Lyon, Gholson J., Riviere, Jean-Baptiste, Waugh, Jeff L., Sandaradura, Sarah A., Mark, Paul R., Ahlfors, Helena, Cheng, Hanyin, Begtrup, Amber, Lumaka, Aime, Wakeling, Emma, Lumaka Zola, Aimé, Marchi, Elaine, Diaz, Jullianne, Kleyner, Robert, Timmers, H. T. Marc, Willing, Marcia, Faivre, Laurence, Willing, Marcia C., Payne, Katelyn, Oliveira, Jorge, Ades, Lesley C., Roscioli, Tony, Walsh, Laurence   +64 more
core   +7 more sources

Tafbromin selectively targets the TAF1 bromodomain

Angewandte Chemie
Phenotypic assays detect small-molecule bioactivity at functionally relevant cellular sites, and inherently cover a variety of targets and mechanisms of action.
Zumer, K., Waldmann, H., Ziegler, S., Cramer, P., Janning, P., Flegel, J., Patil, S., Cramer, P. ; https://orcid.org/, Maier, K., Sievers, S., Schulte, B., Cremosnik, G., Dötsch, L.   +12 more
core   +6 more sources

The Cytoplasmic Domain of Xenopus NF-Protocadherin Interacts with TAF1/Set [PDF]

Developmental Cell, 2003
Protocadherins are members of the cadherin superfamily of cell adhesion molecules proposed to play important roles in early development, but whose mechanisms of action are largely unknown. We examined the function of NF-protocadherin (NFPC), a novel cell
Heggem, Mike A, Bradley, Roger S
core   +3 more sources

TAF1, the Largest Subunit of Tfiid, Is Dispensable for Adult Hematopoiesis

Blood, 2023
Temporal and spatial control of gene expression is central to normal hematopoietic stem cell (HSC) biology. Many sequence-specific transcription factors have been identified as key regulators of HSC fate decision, while the function of general ...
Yue, Jingyin, Tamiro, Francesco, Cingaram, Pradeepkumar Reddy, Caja, Concepcion Martinza, Liu, Fan, Hossack, Krystal Lisa, Beckedorff, Felipe, Shiekhattar, Ramin, Sun, Jun, Nimer, Stephen D.   +9 more
core   +2 more sources

G-quadruplexes in an SVA retrotransposon cause aberrant TAF1 gene expression in X-linked dystonia parkinsonism. [PDF]

Nucleic Acids Res
International audienceG-quadruplexes (G4s) are non-canonical nucleic acid structures that form in guanine (G)-rich genomic regions. X-linked dystonia parkinsonism (XDP) is an inherited neurodegenerative disease in which a SINE–VNTR–Alu (SVA ...
Nicoletto G, Terreri M, Maurizio I, Ruggiero E, Cernilogar FM, Vaine CA, Cottini MV, Shcherbakova I, Penney EB, Gallina I, Monchaud D, Bragg DC, Schotta G, Richter SN.   +13 more
europepmc   +2 more sources

TFIID dependency of steady-state mRNA transcription altered epigenetically by simultaneous functional loss of Taf1 and Spt3 is Hsp104-dependent

PLoS ONE, 2023
In Saccharomyces cerevisiae, class II gene promoters have been divided into two subclasses, TFIID- and SAGA-dominated promoters or TFIID-dependent and coactivator-redundant promoters, depending on the experimental methods used to measure mRNA levels.
Ryo Iwami, Naoki Takai, Minenosuke Matsutani, Yuh Shiwa, Haruki Kokubo, Koji Kasahara, Tetsuro Kokubo   +6 more
doaj   +2 more sources

Efficacy of Deep Brain Stimulation for the Treatment of Monogenic Dystonia Symptoms: A Systematic Review. [PDF]

Eur J Neurol
To improve the quality of available evidence on the efficacy of DBS for treating monogenic dystonia, we conducted a systematic review in accordance with PRISMA guidelines. Based on the collected evidence, we formulated recommendations for applying DBS in monogenic dystonia.
Indelicato E, Carmona-Hidalgo B, Quintero J, Escobar JDO, Koy A, Salamon A, Tacik P, Muñoz-Delgado L, Giannini G, Reich M, Albanese A, Bäumer T, Grandas F, Jech R, Leonardos A, Mir P, Pérez-Dueñas B, Perez-Sanchez JR, Valldeoriola F, Zanni G, Vidailhet M, Rodríguez-López R, Blasco-Amaro JA, Reinhard C, Boesch S, European Reference Network for Rare Neurological Diseases (ERN‐RND).   +25 more
europepmc   +2 more sources