Results 21 to 30 of about 4,594 (188)

Generation of a Monoclonal Antibody Specifically Reacting with Neuron-specific TATA-Box Binding Protein-Associated Factor 1 (N-TAF1)

Antibodies, 2012
TATA-box binding protein-associated factor 1 (TAF1), the largest subunit of the transcription factor IID complex, plays an important role in the RNA polymerase II-mediated gene transcription pathway regulating the transcription of a large number of genes
Gen Tamiya, Ikuo Tooyama, Satoshi Ando, Chiaki Masuda, Satoshi Makino   +4 more
doaj   +2 more sources

TFIID dependency of steady-state mRNA transcription altered epigenetically by simultaneous functional loss of Taf1 and Spt3 is Hsp104-dependent

PLoS ONE, 2023
In Saccharomyces cerevisiae, class II gene promoters have been divided into two subclasses, TFIID- and SAGA-dominated promoters or TFIID-dependent and coactivator-redundant promoters, depending on the experimental methods used to measure mRNA levels.
Ryo Iwami, Naoki Takai, Minenosuke Matsutani, Yuh Shiwa, Haruki Kokubo, Koji Kasahara, Tetsuro Kokubo   +6 more
doaj   +3 more sources

Evaluation of the effects of the T-type calcium channel enhancer SAK3 in a rat model of TAF1 deficiency

Neurobiology of Disease, 2021
The TATA-box binding protein associated factor 1 (TAF1) is part of the TFIID complex that plays a key role during the initiation of transcription. Variants of TAF1 are associated with neurodevelopmental disorders.
Kohji Fukunaga, Rajesh Khanna, Aubin Moutal   +2 more
exaly   +3 more sources

Infantile Epileptic Spasm Syndrome Caused by <i>TAF1</i> Missense Variants: Expanding the Epileptic Phenotype and Revealing Underlying Impairments in Neuronal Excitability and Development. [PDF]

Hum Mutat
Background Pathogenic variants in TAF1 have previously been associated with X‐linked intellectual disability and X‐linked dystonia‐parkinsonism.
Xiao H, Xie C, Peng P, Ni X, Mao L, Peng J.   +5 more
europepmc   +2 more sources

Deletion of taf1 and taf5 in zebrafish capitulate cardiac and craniofacial abnormalities associated with TAFopathies through perturbations in metabolism

Biology Open, 2023
Intellectual disability is a neurodevelopmental disorder that affects 2-3% of the general population. Syndromic forms of intellectual disability frequently have a genetic basis and are often accompanied by additional developmental anomalies.
Jamison Leid, Ryan Gray, Peter Rakita, Andrew L. Koenig, Rohan Tripathy, James A. J. Fitzpatrick, Charles Kaufman, Lilianna Solnica-Krezel, Kory J. Lavine   +8 more
doaj   +2 more sources

The investigation of the T-type calcium channel enhancer SAK3 in an animal model of TAF1 intellectual disability syndrome

Neurobiology of Disease, 2020
T-type calcium channels, in the central nervous system, are involved in the pathogenesis of many neurodegenerative diseases, including TAF1 intellectual disability syndrome (TAF1 ID syndrome).
Kohji Fukunaga, Lisa Boinon
exaly   +3 more sources

LncR-GAS5 decrease in adenine phosphoribosyltransferase expresssion via binding TAF1 to increase kidney damage created by CIH

Heliyon
Objective: Chronic kidney disease (CKD) related to obstructive sleep apnea-hypopnea syndrome (OSAHS) mainly results from chronic intermittent hypoxia (CIH)-induced renal injury.
Wei Liu, Wukaiyang Liang, CunTai Zhang, Huiguo Liu, Hai Li, Lun Zhou, Ling Zhou   +6 more
doaj   +2 more sources

Unified long-read panel for Parkinson’s and repeat expansion disorders [PDF]

npj Parkinson's Disease
In this study, we designed a gene panel based on Nanopore long-read sequencing using adaptive sampling, targeting n = 564 genes associated with Parkinson’s disease (PD) and repeat expansion disorders.
André Fienemann, Julia C. Prietzsche, Joshua Laβ, Christoph Much, Susen Schaake, Theresa Lüth, Carolin Gabbert, Alexander Zimprich, Elisabeth Stögmann, Theresa König, Christos Ganos, Tuğçe Gül-Demirkale, A. Nazlı Başak, Roland Dominic G. Jamora, Raymond L. Rosales, Gerard Saranza, Cid Czarina E. Diesta, Meret Möller, Max Borsche, Teresa Kleinz, Alexander Balck, Norbert Brüggemann, Philip Seibler, Christine Klein, Joanne Trinh   +24 more
doaj   +2 more sources

G-quadruplexes in an SVA retrotransposon cause aberrant TAF1 gene expression in X-linked dystonia parkinsonism. [PDF]

Nucleic Acids Res
G-quadruplexes (G4s) are non-canonical nucleic acid structures that form in guanine (G)-rich genomic regions. X-linked dystonia parkinsonism (XDP) is an inherited neurodegenerative disease in which a SINE–VNTR–Alu (SVA) retrotransposon, characterised by ...
Nicoletto G, Terreri M, Maurizio I, Ruggiero E, Cernilogar FM, Vaine CA, Cottini MV, Shcherbakova I, Penney EB, Gallina I, Monchaud D, Bragg DC, Schotta G, Richter SN.   +13 more
europepmc   +2 more sources

Taf1 expression in mouse: novel transcripts and protein distribution

bioRxiv
TATA-box binding protein associated factor 1 (TAF1) is the largest component of transcription factor IID (TFIID), a fundamental multiprotein complex for RNA polymerase II-mediated transcription.
Li P, Cleverley K, Crombie EM, Bieschke J, Fisher EM, Brown A.   +5 more
europepmc   +2 more sources