Results 1 to 10 of about 3,740 (175)

The roles of TAF1 in neuroscience and beyond [PDF]

Royal Society Open Science
The transcriptional machinery is essential for gene expression and regulation; dysregulation of transcription can result in a range of pathologies, including neurodegeneration, cancer, developmental disorders and cardiovascular disease.
Elisa M Crombie, Karen Cleverley, H T Marc Timmers   +2 more
exaly   +8 more sources

TAF1 is required for fetal but not adult hematopoiesis in mice [PDF]

Developmental Cell
While many sequence-specific transcription factors (TFs) have been identified as key regulators of hematopoietic stem cell (HSC) lineage determination, the function of general TFs in HSC behavior is poorly understood.
Liu F, Yue J, Tamiro F, Sun J, Cingaram PKR, Hossack KL, Caja CM, Xu Y, Chen C, Beckedorff F, Shiekhattar R, Nimer SD.   +11 more
exaly   +5 more sources

Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain

Journal of Medicinal Chemistry, 2022
Bromodomains regulate chromatin remodeling and gene transcription through recognition of acetylated lysines on histones and other proteins. Bromodomain-containing protein TAF1, a subunit of general transcription factor TFIID, initiates preinitiation ...
Lihong Chen (12138), Ernst Schönbrunn (1319238), Justin M. Lopchuk (1333959), Leixiang Yang (8392536), Zachary P. Shultz (12118594), Jiandong Chen (220306), Dylan Grassie (11620581), Junhao Lu (8392533), Rezaul Md Karim (8543853), Melissa J. Bikowitz (10668799)   +9 more
core   +15 more sources

TAF1-gene editing alters the morphology and function of the cerebellum and cerebral cortex

Neurobiology of Disease, 2019
TAF1/MRSX33 intellectual disability syndrome is an X-linked disorder caused by loss-of-function mutations in the TAF1 gene. How these mutations cause dysmorphology, hypotonia, intellectual and motor defects is unknown.
Udaiyappan Janakiraman, Aubin Moutal, Dhanalakshmi Chinnasamy   +2 more
exaly   +4 more sources

Taf1 knockout is lethal in embryonic male mice and heterozygous females show weight and movement disorders [PDF]

Disease Models & Mechanisms
The TATA box-binding protein-associated factor 1 (TAF1) is a ubiquitously expressed protein and the largest subunit of the basal transcription factor TFIID, which plays a key role in initiation of RNA polymerase II-dependent transcription.
Elisa M. Crombie, Andrea J. Korecki, Karen Cleverley, Bethany A. Adair, Thomas J. Cunningham, Weaverly Colleen Lee, Tess C. Lengyell, Cheryl Maduro, Victor Mo, Liam M. Slade, Ines Zouhair, Elizabeth M. C. Fisher, Elizabeth M. Simpson   +12 more
doaj   +4 more sources

Alterations in energy production in a Drosophila model for the X-linked dystonia-parkinsonism-related Taf1 deficiency [PDF]

Frontiers in Aging Neuroscience
BackgroundX-linked dystonia-parkinsonism (XDP), an adult-onset neurodegenerative disorder, is caused by an SVA insertion in the TAF1 gene, containing a hexanucleotide, the length of which is correlated to the severity of the disease.
Frida Mandik, Shela Marie Algodon, Philip Seibler, Christine Klein, Melissa Vos   +4 more
doaj   +2 more sources

Deciphering Selectivity Mechanism of BRD9 and TAF1(2) toward Inhibitors Based on Multiple Short Molecular Dynamics Simulations and MM-GBSA Calculations

Molecules, 2023
BRD9 and TAF1(2) have been regarded as significant targets of drug design for clinically treating acute myeloid leukemia, malignancies, and inflammatory diseases.
Lifei Wang, Juan Zhao, Lulu Zhang
exaly   +3 more sources

TAF1 Suppresses MHC-I Expression and Correlates with Poor Immunotherapy Response in Small Cell Lung Cancer [PDF]

Biomedicines
Background: Small cell lung cancer (SCLC) is an aggressive neuroendocrine tumor characterized by an intrinsic resistance to immunotherapy, primarily due to its low immunogenicity and immune-cold tumor microenvironment.
Qing Gao, Kehong Wei, Deshen Pan, Yufei Xi, Chaoliang Xu, Deshui Jia   +5 more
doaj   +2 more sources

Evaluation of the effects of the T-type calcium channel enhancer SAK3 in a rat model of TAF1 deficiency

Neurobiology of Disease, 2021
The TATA-box binding protein associated factor 1 (TAF1) is part of the TFIID complex that plays a key role during the initiation of transcription. Variants of TAF1 are associated with neurodevelopmental disorders.
Udaiyappan Janakiraman, Aubin Moutal, Kohji Fukunaga   +2 more
exaly   +3 more sources

Generation of a Monoclonal Antibody Specifically Reacting with Neuron-specific TATA-Box Binding Protein-Associated Factor 1 (N-TAF1)

Antibodies, 2012
TATA-box binding protein-associated factor 1 (TAF1), the largest subunit of the transcription factor IID complex, plays an important role in the RNA polymerase II-mediated gene transcription pathway regulating the transcription of a large number of genes
Gen Tamiya, Ikuo Tooyama, Satoshi Ando, Chiaki Masuda, Satoshi Makino   +4 more
doaj   +2 more sources