The roles of TAF1 in neuroscience and beyond [PDF]
Royal Society Open ScienceThe transcriptional machinery is essential for gene expression and regulation; dysregulation of transcription can result in a range of pathologies, including neurodegeneration, cancer, developmental disorders and cardiovascular disease.
Marc Timmers +2 more
exaly +9 more sources
TAF1 is required for fetal but not adult hematopoiesis in mice [PDF]
Developmental CellWhile many sequence-specific transcription factors (TFs) have been identified as key regulators of hematopoietic stem cell (HSC) lineage determination, the function of general TFs in HSC behavior is poorly understood.
Krystal Lisa Hossack
exaly +6 more sources
Molecules, 2023 BRD9 and TAF1(2) have been regarded as significant targets of drug design for clinically treating acute myeloid leukemia, malignancies, and inflammatory diseases.
Lifei Wang, Lulu Zhang
exaly +5 more sources
Alterations in energy production in a Drosophila model for the X-linked dystonia-parkinsonism-related Taf1 deficiency [PDF]
Frontiers in Aging NeuroscienceBackgroundX-linked dystonia-parkinsonism (XDP), an adult-onset neurodegenerative disorder, is caused by an SVA insertion in the TAF1 gene, containing a hexanucleotide, the length of which is correlated to the severity of the disease.
Frida Mandik +4 more
doaj +4 more sources
A screen of chromatin-targeting compounds identifies TAF1 as a novel regulator of HIV latency [PDF]
mBioAntiretroviral therapy suppresses HIV replication but fails to eliminate the virus due to the persistence of a transcriptionally silent reservoir, which remains the primary barrier to a cure.
Samuel D. Burgos +6 more
doaj +4 more sources
The role of uncharacterized protein Taf1 in regulating ATP levels and virulence of Cryptococcus neoformans [PDF]
BMC MicrobiologyThe human fungal pathogen Cryptococcus neoformans poses significant health risks, particularly to immunocompromised individuals, such as those with HIV/AIDS.
Yuanyuan Ma +6 more
doaj +3 more sources
TAF1 Suppresses MHC-I Expression and Correlates with Poor Immunotherapy Response in Small Cell Lung Cancer [PDF]
BiomedicinesBackground: Small cell lung cancer (SCLC) is an aggressive neuroendocrine tumor characterized by an intrinsic resistance to immunotherapy, primarily due to its low immunogenicity and immune-cold tumor microenvironment.
Qing Gao +5 more
doaj +3 more sources
Development and comparison of single FLT3-inhibitors to dual FLT3/TAF1-inhibitors as an anti-leukemic approach. [PDF]
PLoS ONEAcute myeloid leukemia (AML) is characterized by several recurrent mutations that affect disease biology and phenotype, response to therapy and risk of subsequent relapse.
Robert S Leigh +3 more
doaj +3 more sources
Single-molecule imaging reveals RNA polymerase II dynamics and TAF1-dependent promoter-proximal pause release [PDF]
Nature CommunicationsEarly transcriptional regulation is a major kinetic bottleneck in gene expression, yet the dynamics of RNA polymerase II in living cells remain poorly understood.
Nayem Haque +3 more
doaj +3 more sources
OSI-027 as a Potential Drug Candidate Targeting Upregulated Hub Protein TAF1 in Potential Mechanism of Sinonasal Squamous Cell Carcinoma: Insights from Proteomics and Molecular Docking [PDF]
BiologySinonasal squamous cell carcinoma (SNSCC) is a rare tumor with high mortality and recurrence rates. However, SNSCC carcinogenesis mechanisms and potential therapeutic drugs have not been fully elucidated.
Watcharapong Panthong +5 more
doaj +3 more sources