Results 11 to 20 of about 3,740 (175)

TAF1 plays a critical role in AML1-ETO driven leukemogenesis [PDF]

Nature Communications, 2019
AML1-ETO is a fusion protein in which acetylation of lysine-43 is critical to leukemogenesis. Here, they show that TAF1 is required for AML1-ETO mediated gene expression such that it binds to acetylated AML1-ETO to facilitate the association of AML1-ETO ...
Ye Xu, Na Man, Daniel Karl, Concepcion Martinez, Fan Liu, Jun Sun, Camilo Jose Martinez, Gloria Mas Martin, Felipe Beckedorff, Fan Lai, Jingyin Yue, Alejandro Roisman, Sarah Greenblatt, Stephanie Duffort, Lan Wang, Xiaojian Sun, Maria Figueroa, Ramin Shiekhattar, Stephen Nimer   +18 more
doaj   +4 more sources

Association Study of TAF1 Variants in Parkinson’s Disease

Frontiers in Neuroscience, 2022
Increasing evidence reveals sex as an important factor in the development of Parkinson’s disease (PD), but associations between genes on the sex chromosomes and PD remain unknown.
Qian Zeng, Hongxu Pan, Yuwen Zhao, Yige Wang, Qian Xu, Jieqiong Tan, Xinxiang Yan, Jinchen Li, Jinchen Li, Jinchen Li, Beisha Tang, Beisha Tang, Beisha Tang, Beisha Tang, Jifeng Guo, Jifeng Guo, Jifeng Guo, Jifeng Guo, Jifeng Guo   +18 more
doaj   +4 more sources

The role of uncharacterized protein Taf1 in regulating ATP levels and virulence of Cryptococcus neoformans [PDF]

BMC Microbiology
The human fungal pathogen Cryptococcus neoformans poses significant health risks, particularly to immunocompromised individuals, such as those with HIV/AIDS.
Yuanyuan Ma, Kaisu Pan, Ling Shen, Jianhua Qu, Yu Han, Cunwei Cao, Peng Xue   +6 more
doaj   +2 more sources

The investigation of the T-type calcium channel enhancer SAK3 in an animal model of TAF1 intellectual disability syndrome

Neurobiology of Disease, 2020
T-type calcium channels, in the central nervous system, are involved in the pathogenesis of many neurodegenerative diseases, including TAF1 intellectual disability syndrome (TAF1 ID syndrome).
Udaiyappan Janakiraman, Aubin Moutal, Lisa Boinon   +2 more
exaly   +3 more sources

Development and comparison of single FLT3-inhibitors to dual FLT3/TAF1-inhibitors as an anti-leukemic approach. [PDF]

PLoS ONE
Acute myeloid leukemia (AML) is characterized by several recurrent mutations that affect disease biology and phenotype, response to therapy and risk of subsequent relapse.
Robert S Leigh, Bogac L Kaynak, Heikki Ruskoaho, Mika J Välimäki   +3 more
doaj   +2 more sources

Correction of the molecular phenotype of X-linked Dystonia-Parkinsonism reveals a non-canonical function of BRD4 [PDF]

Nature Communications
Transcription and mRNA processing are tightly coupled regulatory layers on gene expression, and their perturbations underly human disorders. X-linked Dystonia-Parkinsonism (XDP) is a unique example of a human disease connecting aberrant mRNA processing ...
Simona Capponi, Sandra Ehret, Zeynep Camgöz, Fabian Gather, Christine A. Vaine, Ezgi Özyerli-Göknar, Marie Follo, D. Cristopher Bragg, Tanja Vogel, H. Th. Marc Timmers   +9 more
doaj   +2 more sources

Novel Functions for TAF7, a Regulator of TAF1-independent Transcription [PDF]

Journal of Biological Chemistry, 2010
The transcription factor TFIID components TAF7 and TAF1 regulate eukaryotic transcription initiation. TAF7 regulates transcription initiation of TAF1-dependent genes by binding to the acetyltransferase (AT) domain of TAF1 and inhibiting the enzymatic ...
Anne Gegonne, Lee, Maxwell P., Ballachanda N. Devaiah, Gegonne, Anne, Clifford, Robert J., Zhang, Hongen, Hongen Zhang, Dinah S. Singer, Maxwell P. Lee, Lu, Hanxin, Devaiah, Ballachanda N., Sercan, Zeynep, Robert J. Clifford, Singer, Dinah S., Zeynep Sercan, Hanxin Lu   +15 more
core   +4 more sources

SVA insertion in X-linked Dystonia Parkinsonism alters histone H3 acetylation associated with TAF1 gene.

PLoS ONE, 2020
X-linked Dystonia-Parkinsonism (XDP) is a neurodegenerative disease linked to an insertion of a SINE-VNTR-Alu (SVA)-type retrotransposon within an intron of TAF1.
Tiziana Petrozziello, Amanda M Dios, Kaly A Mueller, Christine A Vaine, William T Hendriks, Kelly E Glajch, Alexandra N Mills, Kotchaphorn Mangkalaphiban, Ellen B Penney, Naoto Ito, Cara Fernandez-Cerado, Gierold Paul A Legarda, M Salvie Velasco-Andrada, Patrick J Acuña, Mark A Ang, Edwin L Muñoz, Cid Czarina E Diesta, Regina Macalintal-Canlas, Geraldine Acuña, Nutan Sharma, Laurie J Ozelius, D Cristopher Bragg, Ghazaleh Sadri-Vakili   +22 more
doaj   +2 more sources

OSI-027 as a Potential Drug Candidate Targeting Upregulated Hub Protein TAF1 in Potential Mechanism of Sinonasal Squamous Cell Carcinoma: Insights from Proteomics and Molecular Docking [PDF]

Biology
Sinonasal squamous cell carcinoma (SNSCC) is a rare tumor with high mortality and recurrence rates. However, SNSCC carcinogenesis mechanisms and potential therapeutic drugs have not been fully elucidated.
Watcharapong Panthong, Chamsai Pientong, Thawaree Nukpook, Chukkris Heawchaiyaphum, Sirinart Aromseree, Tipaya Ekalaksananan   +5 more
doaj   +2 more sources

An in-silico pan-cancer bulk and single-cell profiling of transcription factors in protein autoubiquitination [PDF]

Discover Oncology
The protein autoubiquitination has emerged as a significant focus in pan-cancer genetic research due to its potential impact on cancer progression and treatment.
Angela Dong, Ayana Rasteh, Panpan Wang, Hengrui Liu   +3 more
doaj   +2 more sources