Results 11 to 20 of about 4,594 (188)

Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain.

Journal of Medicinal Chemistry, 2022
Bromodomains regulate chromatin remodeling and gene transcription through recognition of acetylated lysines on histones and other proteins. Bromodomain-containing protein TAF1, a subunit of general transcription factor TFIID, initiates preinitiation ...
R. Karim, Lei-Xiang Yang, Li-Hong Chen, M. Bikowitz, Jun-Hao Lu, Dylan Grassie, Z. Shultz, J. Lopchuk, J. Chen, E. Schönbrunn   +9 more
semanticscholar   +16 more sources

Mechanistic insights into DNA binding by BD1 of the TAF1 tandem bromodomain module. [PDF]

Biochem J
Transcription initiation factor TFIID subunit 1 (TAF1) is a pivotal component of the TFIID complex, critical for RNA polymerase II-mediated transcription initiation.
Yadav Y, Chyne P, Sudhamalla B.
europepmc   +4 more sources

Harnessing the TAF1 Acetyltransferase for Targeted Acetylation of the Tumor Suppressor p53. [PDF]

Adv Sci (Weinh)
Pharmacological reactivation of the tumor suppressor p53 remains a key challenge for the treatment of cancer. Acetylation Targeting Chimera (AceTAC), a novel technology is previously reported that hijacks lysine acetyltransferases p300/CBP to acetylate ...
Kabir M, Hu X, Martin TC, Pokushalov D, Kim YJ, Chen Y, Zhong Y, Wu Q, Chipuk JE, Shi Y, Xiong Y, Gu W, Parsons RE, Jin J.   +13 more
europepmc   +4 more sources

Tafbromin selectively targets the TAF1 bromodomain. [PDF]

Angewandte Chemie
Phenotypic assays detect small molecule bioactivity at functionally relevant cellular sites, and inherently cover a variety of targets and mechanisms of action.
S. Patil, Gregor Cremosnik, L. Dötsch, Jana Flegel, Britta Schulte, Kerstin C. Maier, Kristina Žumer, Patrick Cramer, P. Janning, S. Sievers, Slava Ziegler, H. Waldmann   +11 more
semanticscholar   +7 more sources

TAF1 plays a critical role in AML1-ETO driven leukemogenesis [PDF]

Nature Communications, 2019
AML1-ETO is a fusion protein in which acetylation of lysine-43 is critical to leukemogenesis. Here, they show that TAF1 is required for AML1-ETO mediated gene expression such that it binds to acetylated AML1-ETO to facilitate the association of AML1-ETO ...
Ye Xu, Na Man, Daniel Karl, Concepcion Martinez, Fan Liu, Jun Sun, Camilo Jose Martinez, Gloria Mas Martin, Felipe Beckedorff, Fan Lai, Jingyin Yue, Alejandro Roisman, Sarah Greenblatt, Stephanie Duffort, Lan Wang, Xiaojian Sun, Maria Figueroa, Ramin Shiekhattar, Stephen Nimer   +18 more
doaj   +4 more sources

Taf1 knockout is lethal in embryonic male mice and heterozygous females show weight and movement disorders [PDF]

Disease Models & Mechanisms
The TATA box-binding protein-associated factor 1 (TAF1) is a ubiquitously expressed protein and the largest subunit of the basal transcription factor TFIID, which plays a key role in initiation of RNA polymerase II-dependent transcription.
Elisa M. Crombie, Andrea J. Korecki, Karen Cleverley, Bethany A. Adair, Thomas J. Cunningham, Weaverly Colleen Lee, Tess C. Lengyell, Cheryl Maduro, Victor Mo, Liam M. Slade, Ines Zouhair, Elizabeth M. C. Fisher, Elizabeth M. Simpson   +12 more
doaj   +4 more sources

TAF1 acetyltransferase promotes colorectal carcinoma metastasis by catalyzing β-hydroxybutyrylation of KCTD9. [PDF]

Oncogene
Colorectal carcinoma (CRC) ranks as the second leading cause of cancer mortality worldwide. However, the mechanisms underlying CRC progression and metastasis, remain unclear. Our current research has identified that TATA-binding protein-associated factor-
Su J, Zhao M, Feng W, Lin Y, Lu X, Xia Z, Cheng T, Liu Q, Cheng L, Pu C, Zhang A, Tang J, Yu B.   +12 more
europepmc   +2 more sources

PROTAC-Mediated Degradation of TAF1 Induces Apoptosis in AML Cells and Inhibits Tumor Growth In Vivo. [PDF]

Mol Cancer Ther
The bromodomain-containing protein TAF1 (TFII-250) is the largest component of the multiprotein assembly TFIID, a dynamic complex that serves as a general factor for transcription initiation. CRISPR and RNAi screens of pan cancer cell lines revealed TAF1
Chen L, Shultz ZP, Sansone M, Fang B, Liu X, Teng M, Schonbrunn E, Lopchuk JM, Chen J.   +8 more
europepmc   +2 more sources

Association Study of TAF1 Variants in Parkinson’s Disease

Frontiers in Neuroscience, 2022
Increasing evidence reveals sex as an important factor in the development of Parkinson’s disease (PD), but associations between genes on the sex chromosomes and PD remain unknown.
Qian Zeng, Hongxu Pan, Yuwen Zhao, Yige Wang, Qian Xu, Jieqiong Tan, Xinxiang Yan, Jinchen Li, Jinchen Li, Jinchen Li, Beisha Tang, Beisha Tang, Beisha Tang, Beisha Tang, Jifeng Guo, Jifeng Guo, Jifeng Guo, Jifeng Guo, Jifeng Guo   +18 more
doaj   +4 more sources

Novel Functions for TAF7, a Regulator of TAF1-independent Transcription [PDF]

Journal of Biological Chemistry, 2010
The transcription factor TFIID components TAF7 and TAF1 regulate eukaryotic transcription initiation. TAF7 regulates transcription initiation of TAF1-dependent genes by binding to the acetyltransferase (AT) domain of TAF1 and inhibiting the enzymatic activity that is essential for transcription.
Singer, Dinah S., Sercan, Zeynep, Clifford, Robert J., Lu, Hanxin, Devaiah, Ballachanda N., Lee, Maxwell P., Zhang, Hongen, Gegonne, Anne   +7 more
openaire   +4 more sources