Results 31 to 40 of about 4,594 (188)

Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains [PDF]

Journal of Medicinal Chemistry, 2017
Bromodomains (BD) are readers of lysine acetylation marks present in numerous proteins associated with chromatin. Here we describe a dual inhibitor of the bromodomain and PHD finger (BRPF) family member BRPF2 and the TATA box binding protein-associated factors TAF1 and TAF1L.
Bouche, Lea; Christ, Clara D.; Siegel, Stephan; Fernandez-Montalvan, Amaury E.; Holton, Simon J.; Fedorov, Oleg; ter Laak, Antonius; Sugawara, Tatsuo; Stoeckigt, Detlef; Tallant, Cynthia; Bennett, James; Monteiro, Octovia; Diaz-Saez, Laura; Siejka, Paulina; Meier, Julia; Puetter, Vera; Weiske, Joerg; Mueller, Susanne; Huber, Kilian V. M.; Hartung, Ingo V.; Haendler, Bernard   +21 more
openaire   +4 more sources

Correction of the molecular phenotype of X-linked Dystonia-Parkinsonism reveals a non-canonical function of BRD4 [PDF]

Nature Communications
Transcription and mRNA processing are tightly coupled regulatory layers on gene expression, and their perturbations underly human disorders. X-linked Dystonia-Parkinsonism (XDP) is a unique example of a human disease connecting aberrant mRNA processing ...
Simona Capponi, Sandra Ehret, Zeynep Camgöz, Fabian Gather, Christine A. Vaine, Ezgi Özyerli-Göknar, Marie Follo, D. Cristopher Bragg, Tanja Vogel, H. Th. Marc Timmers   +9 more
doaj   +2 more sources

Decreased N-TAF1 expression in X-linked dystonia-parkinsonism patient-specific neural stem cells [PDF]

Disease Models & Mechanisms, 2016
X-linked dystonia-parkinsonism (XDP) is a hereditary neurodegenerative disorder involving a progressive loss of striatal medium spiny neurons. The mechanisms underlying neurodegeneration are not known, in part because there have been few cellular models ...
Naoto Ito, William T. Hendriks, Jyotsna Dhakal, Christine A. Vaine, Christina Liu, David Shin, Kyle Shin, Noriko Wakabayashi-Ito, Marisela Dy, Trisha Multhaupt-Buell, Nutan Sharma, Xandra O. Breakefield, D. Cristopher Bragg   +12 more
doaj   +2 more sources

The Clinical, Genetic, Psychosocial, and Care Landscape of X-Linked Dystonia-Parkinsonism in Filipino Men: A Scoping Review [PDF]

American Journal of Men's Health
Background X-linked dystonia-parkinsonism (XDP) is a hereditary movement disorder predominantly affecting Filipino males from Panay Island ancestry.
Mary Dioise Ramos PhD, RN, CNE, FAAN, Jennifer Manning DNS, ACNS-BC, CNE, FCNS, Jolie Harris DNS, RN, CAS, Marie Adorno PhD, APRN, CNS, RNC-MNN, CNE, Rowan Marye MLIS, BFA, Lorraine Evangelista PhD, RN, FAHA, FAAN   +5 more
doaj   +2 more sources

TAF1-dependent transcriptional dysregulation underlies multiple sclerosis

bioRxiv
A major conceptual and clinical challenge in multiple sclerosis (MS) is understanding the mechanisms that drive the central nervous system (CNS)-resident neuroinflammation and neurodegeneration underneath disease progression.
C. Rodríguez-López, Ivó H. Hernández, José Terrón-Bautista, E. Agirre, Julia Pose-Utrilla, D. Lozano-Muñoz, Irene Ruiz-Blas, Alejandra M. Arroyo, I. García-Ortiz, Miriam Lucas-Santamaría, María González-Bermejo, M. C. Ortega, I. Machín-Díaz, J. Chara, T. Morrema, Chao Zheng, Zara Martínez, F. Pérez-Cerdá, M. Martínez-Jiménez, Beatriz Sancho-González, Alberto Pérez-Samartín, Mukund Kabbe, Marcos Casado-Barbero, María Santos-Galindo, A. Borroto, Balbino Alarcón, A. Paradela, F. de Castro, N. Fransen, J. Hoozemans, C. Toma, Carlos Matute, Diego Clemente, Felipe Cortés-Ledesma, G. Castelo-Branco, José J. Lucas   +35 more
semanticscholar   +4 more sources

An in-silico pan-cancer bulk and single-cell profiling of transcription factors in protein autoubiquitination [PDF]

Discover Oncology
The protein autoubiquitination has emerged as a significant focus in pan-cancer genetic research due to its potential impact on cancer progression and treatment.
Angela Dong, Ayana Rasteh, Panpan Wang, Hengrui Liu   +3 more
doaj   +2 more sources

NSP7 Molecular Degrader Attenuates Coronaviral Infection Through the β‐TrCP1/FBXO5 Axis [PDF]

Advanced Science
NSP7 (Non‐Structural Protein 7) of SARS‐CoV‐2 is a crucial component for viral replication and transcription. In this study, it is revealed that the host E3 ubiquitin ligase FBXO5 suppresses viral replication by mediating NSP7 lysine‐48‐linked ...
Yao Tong, Travis B. Lear, Ferhan Tuncer, John J. Villandre, Áine N. Boudreau, Bo Lin, Irene Alfaras, Jason R. Kennerdell, Daniel P. Camarco, Mads B. Larsen, Yun Hua, Yanwen Chen, Meigin E. Chandler, Ricardo Pineda, Simon M. Barratt‐Boyes, John W. Evankovich, Toren Finkel, Yuan Liu, Bill B. Chen   +18 more
doaj   +2 more sources

TAF1 aggravates ferroptosis by promoting the ubiquitin-mediated degradation of nuclear GPX4. [PDF]

J Zhejiang Univ Sci B
Ye K, Gan M, Sun L, Chen C, Lai X, He Y, Zhu M, Jiang W, Zhang H.   +8 more
europepmc   +2 more sources

Targeting Oxidative and Immune Dysregulation in Wound Healing via Gold Nanoparticle Conjugate Chitosan. [PDF]

FASEB J
This gold nanoparticle–chitosan (AuNP@chitosan) composite promotes burn wound healing by simultaneously regulating endothelial and immune responses. In vitro, the composite protects TNF‐α‐injured HUVECs by reducing ROS, restoring thrombomodulin, and upregulating hypoxia‐adaptive markers.
Hsu SD, Chang SJ, Lin CA, Fan GY, Tsai HD, Lin A, Cherng JH.   +6 more
europepmc   +2 more sources

TAF1 SPLICING VARIANTS AND PROLYL HYDROXYLASE INHIBITORS IN HUNTINGTON’S DISEASE

IBRO Neuroscience Reports, 2023
Claudia Rodríguez-López, Ivó Hernández Hernández, María González-Bermejo, Marcos Casado Barbero, José Lucas   +4 more
doaj   +2 more sources