Results 31 to 40 of about 3,740 (175)

TAF1-dependent transcriptional dysregulation underlies multiple sclerosis

Tesis Doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Medicina, Departamento de Biología Molecular. Fecha de Lectura: 20-06-2025Esta Tesis tiene embargado el acceso al texto completo hasta el 20-12-2026La esclerosis múltiple (EM)
Rodríguez López, Claudia
core   +4 more sources

A novel variant in TAF1 affects gene expression and is associated with X-linked TAF1 intellectual disability syndrome [PDF]

Neuronal Signaling, 2018
We investigated the genome of a 5-year-old male who presented with global developmental delay (motor, cognitive, and speech), hypotonia, possibly ataxia, and cerebellar hypoplasia of unknown origin. Whole genome sequencing (WGS) and mRNA sequencing (RNA-seq) were performed on a family having an affected proband, his unaffected parents, and maternal ...
Hurst, Sarah E., Liktor-Busa, Erika, Moutal, Aubin, Parker, Sara, Rice, Sydney, Szelinger, Szabolcs, Senner, Grant, Hammer, Michael F., Johnstone, Laurel, Ramsey, Keri, Narayanan, Vinodh, Perez-Miller, Samantha, Khanna, May, Dahlin, Heather, Lewis, Karen, Craig, David, Wang, Edith H., Khanna, Rajesh, Nelson, Mark A.   +18 more
openaire   +2 more sources

Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a role for TAF1 in cell G1 progression. [PDF]

Molecular cell, 2004
The largest subunit of TFIID, TAF1, possesses an intrinsic protein kinase activity and is important for cell G1 progression and apoptosis. Since p53 functions by inducing cell G1 arrest and apoptosis, we investigated the link between TAF1 and p53. We found that TAF1 induces G1 progression in a p53-dependent manner.
Heng-Hong, Li, Andrew G, Li, Hilary M, Sheppard, Xuan, Liu   +3 more
openaire   +2 more sources

Identifying clinical features and molecular characteristics of the endometrial clear cell carcinoma

Frontiers in Oncology, 2023
ObjectiveThe aim of this study was to verify TCGA subtypes in endometrial clear cell carcinoma (ECCC) and determine their clinical and molecular characteristics.MethodsWe summarized and compared the clinical features of 28 clear cell carcinoma and 112 ...
Yuhan Cai, Qin Han, Hongyan Guo
doaj   +1 more source

Yeast Bromodomain Factor 1 and Its Human Homolog TAF1 Play Conserved Roles in Promoting Homologous Recombination

Advanced Science, 2021
Histone acetylation is a key histone post‐translational modification that shapes chromatin structure, dynamics, and function. Bromodomain (BRD) proteins, the readers of acetyl‐lysines, are located in the center of the histone acetylation‐signaling ...
Haoyang Peng, Simin Zhang, Yihan Peng, Shuangyi Zhu, Xin Zhao, Xiaocong Zhao, Shuangshuang Yang, Guangxue Liu, Yang Dong, Xiaoli Gan, Qing Li, Xinghua Zhang, Huadong Pei, Xuefeng Chen   +13 more
doaj   +1 more source

Genome-wide Transcriptional Dependence on TAF1 Functional Domains [PDF]

Journal of Biological Chemistry, 2006
Transcription factor IID (TFIID) plays a central role in regulating the expression of most eukaryotic genes. Of the 14 TBP-associated factor (TAF) subunits that compose TFIID, TAF1 is one of the largest and most functionally diverse. Yeast TAF1 can be divided into four regions including a putative histone acetyltransferase domain and TBP, TAF, and ...
Jordan D, Irvin, B Franklin, Pugh
openaire   +2 more sources

DNA Binding Properties of TAF1 Isoforms with Two AT-hooks [PDF]

Journal of Biological Chemistry, 2006
TATA-binding protein-associated factor 1 (TAF1) is an essential component of the general transcription factor IID (TFIID), which nucleates assembly of the preinitiation complex for transcription by RNA polymerase II. TATA-binding protein and TAF1.TAF2 heterodimers are the only components of TFIID shown to bind specific DNA sequences (the TATA box and ...
Chad E, Metcalf, David A, Wassarman
openaire   +2 more sources

X-Linked Dystonia Parkinsonism: Clinical Phenotype, Genetics and Therapeutics [PDF]

Journal of Movement Disorders, 2010
The clinical phenotype of X-Linked Dystonia Parkinsonism (XDP) is typically one that involves a Filipino adult male whose ancestry is mostly traced in the Philippine island of Panay.
Raymond L. Rosales
doaj   +1 more source

Harnessing the TAF1 Acetyltransferase for Targeted Acetylation of the Tumor Suppressor p53. [PDF]

Adv Sci (Weinh)
AbstractPharmacological reactivation of the tumor suppressor p53 remains a key challenge for the treatment of cancer. Acetylation Targeting Chimera (AceTAC), a novel technology is previously reported that hijacks lysine acetyltransferases p300/CBP to acetylate the p53Y220C mutant.
Kabir M, Hu X, Martin TC, Pokushalov D, Kim YJ, Chen Y, Zhong Y, Wu Q, Chipuk JE, Shi Y, Xiong Y, Gu W, Parsons RE, Jin J.   +13 more
europepmc   +3 more sources

Decreased N-TAF1 expression in X-linked dystonia-parkinsonism patient-specific neural stem cells

Disease Models & Mechanisms, 2016
X-linked dystonia-parkinsonism (XDP) is a hereditary neurodegenerative disorder involving a progressive loss of striatal medium spiny neurons. The mechanisms underlying neurodegeneration are not known, in part because there have been few cellular models ...
Naoto Ito, William T. Hendriks, Jyotsna Dhakal, Christine A. Vaine, Christina Liu, David Shin, Kyle Shin, Noriko Wakabayashi-Ito, Marisela Dy, Trisha Multhaupt-Buell, Nutan Sharma, Xandra O. Breakefield, D. Cristopher Bragg   +12 more
doaj   +1 more source