Results 71 to 80 of about 3,740 (175)
TAF1 bromodomain inhibition as a candidate epigenetic driver of congenital heart disease
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2023 Heart formation requires transcriptional regulators that underlie congenital anomalies and the fetal gene program activated during heart failure. Attributing the effects of congenital heart disease (CHD) missense variants to disruption of specific protein domains allows for a mechanistic understanding of CHDs and improved diagnostics.
Kaynak Bogac +3 more
openaire +3 more sources
Movement Disorders Clinical Practice, Volume 13, Issue 3, Page 774-778, March 2026.Abstract Background Anticholinergic medications and botulinum neurotoxin injections are established treatments for dystonia, yet they carry potential side effects and practical challenges. Deep brain stimulation (DBS) is offered in case of poor response to these approaches.
Marcela A. Montiel +5 more
wiley +1 more source
, 2022 Combinatorial readout of histone post-translational modifications by tandem reader modules mediates crosstalk among different histone modifications. To identify the domain-specific interactome of the tandem reader, we engineered the dual bromodomain of ...
Jyotirmayee Padhan +9 more
core +1 more source
Clinicopathological Phenotype and Genetics of X-Linked Dystonia–Parkinsonism (XDP; DYT3; Lubag)
Brain Sciences, 2017 X-linked dystonia–parkinsonism (XDP; OMIM314250), also referred to as DYT3 dystonia or “Lubag” disease, was first described as an endemic disease in the Philippine island of Panay.
Toshitaka Kawarai +3 more
doaj +1 more source
Immunology, Volume 177, Issue 2, Page 317-328, February 2026.LAG‐3+ regulatory T cells suppress the effector but not the proliferative response of naïve cognate antigen‐specific CD4+ T cells in vivo. The suppressed T cells display upregulation of immune checkpoints and downregulation of pro‐inflammatory pathways with enhanced TCR signaling and reduced oxidative metabolism.
Avijit Dutta +7 more
wiley +1 more source
Advanced Science, Volume 13, Issue 4, 19 January 2026.This study presents the first pan‐transposable element (TE) atlas in rapeseed, profiling over 8 million TEs across 2311 accessions. Integrative analyses reveal that TEs broadly shape gene expression through diverse regulatory mechanisms, with key insertions in BnaA03.FLC and BnaA09.CYP78A9 linked to flowering time and silique development.
Zhiquan Yang +9 more
wiley +1 more source
Therapeutic potential of TAF1 bromodomains for cancer treatment
, 2018 ABSTRACT The discovery of the antiproliferative effects of BRD4 bromodomain inhibitors prompted us to investigate additional bromodomains that might be involved in supporting cellular proliferation. TAF1 is a general transcription factor with two bromodomains that is likely to play important roles in cell viability by supporting ...
Garcia-Carpizo, Veronica +3 more
openaire +1 more source
Activation of a DNA Damage Checkpoint Response in a TAF1-Defective Cell Line [PDF]
Molecular and Cellular Biology, 2004 Although the link between transcription and DNA repair is well established, defects in the core transcriptional complex itself have not been shown to elicit a DNA damage response. Here we show that a cell line with a temperature-sensitive defect in TBP-associated factor 1 (TAF1), a component of the TFIID general transcription complex, exhibits ...
Ann M, Buchmann +2 more
openaire +2 more sources
eLife, 2017 General transcription factor TFIID is a key component of RNA polymerase II transcription initiation. Human TFIID is a megadalton-sized complex comprising TATA-binding protein (TBP) and 13 TBP-associated factors (TAFs).
Kapil Gupta +20 more
doaj +1 more source
Rare but Relevant? Assessing Variants in Dystonia‐Linked Genes in Parkinson's Disease
Movement Disorders, Volume 41, Issue 1, Page 247-259, January 2026.Abstract Background Dystonia and Parkinson's disease (PD) exhibit clinical and genetic overlap, but the relevance of dystonia gene variants in PD remains unclear. Objective The aim was to assess the frequency of dystonia‐linked pathogenic variants in PD.
Lara M. Lange +37 more
wiley +1 more source