Results 71 to 80 of about 4,594 (188)

Rare‐Variant Burden Analysis of Dystonia Genes in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Dystonia frequently coexists with Parkinson's disease (PD), yet the extent of genetic overlap remains insufficiently explored. Objective The aim was to examine whether rare variants in dystonia‐related genes are associated with PD or early‐onset PD (EOPD).
Sajanth Kanagasingam, Sitki Cem Parlar, Lang Liu, Ziv Gan‐Or, Konstantin Senkevich   +4 more
wiley   +1 more source

CIITA and its dual roles in MHC gene transcription

Frontiers in Immunology, 2013
CIITA is a transcriptional co-activator that regulates γ-interferon-activated transcription of Major Histocompatibility Complex (MHC) class I and class II genes.
Dinah S. Singer, Ballachanda Nanjappa Devaiah   +1 more
doaj   +1 more source

The synergistic interaction landscape of chromatin regulators reveals their epigenetic regulation mechanisms across five cancer cell lines

Computational and Structural Biotechnology Journal, 2022
Chromatin regulators (CRs) regulate the gene transcription process through combinatorial patterns, which currently remain obscure for pan-cancer. This study identified the interaction of CRs and constructed CR-CR interaction networks across five tumor ...
Meng Cao, Liqiang Wang, Dahua Xu, Xiaoman Bi, Shengnan Guo, Zhizhou Xu, Liyang Chen, Dehua Zheng, Peihu Li, Jiankai Xu, Shaojiang Zheng, Hong Wang, Bo Wang, Jianping Lu, Kongning Li   +14 more
doaj   +1 more source

TOP1MT rs2293925 is an enhancer‐active regulatory SNP that shapes mitochondrial R‐loop dynamics

The FEBS Journal, EarlyView.
This study shows how a common genetic variant of mitochondrial topoisomerase 1 (TOP1MT rs2293925) can influence mitochondrial gene regulation, DNA topology, and formation of noncanonical nucleic acid structures such as R‐loops. By linking this enhancer‐active variant to mitochondrial nucleic acid stress in cellular contexts relevant to amyotrophic ...
Dóra Varga, Zsolt Ráduly, Beáta Boros‐Oláh, Éva Nagy, Zsolt Karányi, László Halász, Bálint László Bálint, György Vámosi, Emese Tóth, Péter Bai, Serena Santangelo, Patrizia Bossolasco, Antonia Ratti, Vincent Géli, Yves Pommier, Lóránt Székvölgyi   +15 more
wiley   +1 more source

Bioinformatics Identification of lncRNA‐Associated Molecular Signatures Potentially Related to Quercetin Response in Breast Cancer

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Breast cancer affects approximately one in every eight women globally, as reported by the World Health Organization. Among all female malignant tumors, breast cancer has the highest fatality rate, surpassed only by lung cancer. Advanced stages of this disease are almost always fatal, and despite the advancements in surgical techniques and ...
Mahboobeh Mehrabani Natanzi, Zohreh Khodaii, Naghmeh Zhalehjoo   +2 more
wiley   +1 more source

Role of the pre-initiation complex in Mediator recruitment and dynamics

eLife, 2018
The Mediator complex stimulates the cooperative assembly of a pre-initiation complex (PIC) and recruitment of RNA Polymerase II (Pol II) for gene activation. The core Mediator complex is organized into head, middle, and tail modules, and in budding yeast
Elisabeth R Knoll, Z Iris Zhu, Debasish Sarkar, David Landsman, Randall H Morse   +4 more
doaj   +1 more source

Gastric cancer biomarkers; A systems biology approach

Biochemistry and Biophysics Reports, 2018
Gastric cancer is one of the most fatal cancers in the world. Many efforts in recent years have attempted to find effective proteins in gastric cancer. By using a comprehensive list of proteins involved in gastric cancer, scientists were able to retrieve
Mohammad Saberi Anvar, Zarrin Minuchehr, Mohsen Shahlaei, Samira Kheitan   +3 more
doaj   +1 more source

Elucidating Hexanucleotide Repeat Number and Methylation within the X-Linked Dystonia-Parkinsonism (XDP)-Related SVA Retrotransposon in TAF1 with Nanopore Sequencing

Genes, 2022
Background: X-linked dystonia-parkinsonism (XDP) is an adult-onset neurodegenerative disorder characterized by progressive dystonia and parkinsonism.
Theresa Lüth, Joshua La, S. Schaake, I. Wohlers, J. Pozojevic, R. D. Jamora, R. Rosales, N. Bruggemann, Gerard Saranza, C. Diesta, Kathleen Schlüter, R. Tse, C. J. Reyes, M. Brand, H. Busch, C. Klein, A. Westenberger, J. Trinh   +17 more
semanticscholar   +1 more source

The Effect of Glucocorticoids on TAF1 Gene Transcription in X-linked Dystonia Parkinsonism

Journal of the ASEAN Federation of Endocrine Societies, 2023
X-linked Dystonia Parkinsonism (XDP) is associated with a SINE-VNTR- Alu (SVA) retrotransposon insertion in an intron of the TAF1 gene that alters gene transcription and splicing. In this study, we determined if the SVA insertion introduces glucocorticoid (GC)-responsive cis-regulatory elements that may contribute to dysregulated TAF1 transcription and
Sam Ezrael Dela Cruz, Pia Bagamasbad
openaire   +2 more sources

Simultaneous functional loss of Spt3 and Taf1 during the strain construction process conferred Taf1/TFIID dependence to the PGK1 promoter.

, 2023
(A) Schematic outline of the three strain construction protocols (#1, #2, and #3) used to generate the SPT3/TAF1 or SPT3/ taf1-N568Δ strains. These three protocols are all comprised of three common steps: (i) chromosomal integration of SPT3 into the AUR1
Koji Kasahara (16607), Tetsuro Kokubo (16614), Minenosuke Matsutani (456193), Naoki Takai (14593072), Haruki Kokubo (14593075), Yuh Shiwa (512008), Ryo Iwami (14593069)   +6 more
core   +1 more source