Results 81 to 90 of about 5,684 (155)

Antithrombotic properties of Tafamidis: An additional protective effect for transthyretin amyloid cardiomyopathy patients

Introduction: Tafamidis is a molecular chaperone that stabilizes the transthyretin (TTR) homo-tetramer, preventing its dissociation and consequent deposition as amyloid fibrils in organ tissues.
Beer, Georgia, Camici, Giovanni G., Franzini, Maria, Kobza, Richard, Niederberger, Rebecca, Kahr, Peter C., Stämpfli, Simon F., Ministrini, Stefano, Hock, Christoph, Cannie, Douglas E., Elliott, Perry, Lüscher, Thomas F., Puspitasari, Yustina M., Akhmedov, Alexander, Vergaro, Giuseppe, Toggweiler, Stefan   +15 more
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Tafamidis improves myocardial longitudinal strain in A97S transthyretin cardiac amyloidosis

Therapeutic Advances in Chronic Disease
Background: Transthyretin cardiomyopathy (ATTR-CM) is a debilitating disease that has received much attention since the emergence of novel treatments.
Yuan-Kun (Aden) Wu, An-Li Yu, Mei-Fang Cheng, Lung-Chun Lin, Ming-Jen Lee, Chia-Hung Chou, Chia-Tung Shun, Hsueh-Wen Hsueh, Jimmy Jyh-Ming Juang, Ping-Huei Tseng, Siao-Ping Lin, Mao-Yuan Su, Chi-Chao Chao, Sung-Tsang Hsieh, Cheng-Hsuan Tsai, Yen-Hung Lin   +15 more
doaj   +1 more source

Serum prealbumin and disease progression in patients with wild-type Transthyretin Cardiomyopathy on treatment with Tafamidis.

reservedSerum transthyretin (sTTR) is the precursor protein of wild type transthyretin amyloid cardiomyopathy (ATTRwt-CM) and the biological target of tafamidis.
BALDAN, MARCO
core  

Safety, Tolerability, and Outcomes of Tafamidis for the Treatment of Acquired Amyloid Neuropathy in Domino Liver Transplant Recipients

Neurology and Therapy
Introduction Acquired amyloid neuropathy is an iatrogenic disease that appears years after a domino liver transplant. The objectives of our study are to analyze the efficacy and tolerability of tafamidis for the treatment of acquired amyloid neuropathy ...
Velina Nedkova-Hristova, Laura Donadeu, Carmen Baliellas, José González-Costello, Laura Lladó, Emma González-Vilatarsana, Valentina Vélez-Santamaría, Miosés Morales de la Prida, Oriol Bestard, Carlos Casasnovas   +9 more
doaj   +1 more source

Diagnosis of Wild-Type Transthyretin Cardiomyopathy and Initiation of Pathogenetic Therapy in an Elderly Patient: A Clinical Observation

Российский журнал гериатрической медицины
The article presents a case study of an 80-year-old patient with wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM). This case demonstrates the importance of comprehensive examination in cases of unexplained heart failure in elderly patients, and
E. E. Esenbekova, Z. A. Asatova, K. A. Eruslanova, A. Yu. Shchedrina, A. T. Shubina, E. A. Koroleva, T. A. Bondarenko, S. R. Gilyarevsky   +7 more
doaj   +1 more source

“Process for preparation of crystalline tafamidis”

The present invention relates to a process for the preparation of crystalline ...
Anonymous
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Survival in a Real-World Cohort of Patients With Transthyretin Amyloid Cardiomyopathy Treated With Tafamidis: An Analysis From the Transthyretin Amyloidosis Outcomes Survey (THAOS). [PDF]

In the pivotal Tafamidis in Transthyretin Cardiomyopathy Clinical Trial (ATTR-ACT), tafamidis significantly reduced mortality rates, leading to its approval in many countries for the treatment of transthyretin amyloid cardiomyopathy (ATTR-CM). Real-world
Kristen, Arnt V, Drachman, Brian, Carlsson, Martin, Angeli, Franca Stedile, Maurer, Mathew S, Amass, Leslie, Garcia-Pavia, Pablo, THAOS Investigators   +7 more
core   +1 more source

The effect of long-term tafamidis treatment on quality of life in people with transthyretin amyloid cardiomyopathy (ATTR-CM): a plain language summary [PDF]

[Abstract] What is this summary about?: This summary explains some results of a study called ATTR-ACT and its ongoing long-term extension study that were published in the European Journal of Heart Failure.
Sultan, Marla B., Angeli, Franca Stedile, Davis, Margot K., Crespo-Leiro, María Generosa, Grogan, Martha, Gundapaneni, Balarama   +5 more
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Outcomes in Cardiac Transthyretin Amyloidosis and Association With New York Heart Association Class: Real‐World Data

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Results from ATTR‐ACT (Safety and Efficacy of Tafamidis in Patients With Transthyretin Cardiomyopathy) indicate that tafamidis prolongs survival and reduces cardiovascular hospitalizations in cardiac transthyretin amyloidosis (ATTR‐CA ...
Maximilian Leo Müller, Ekaterina Latinova, Anna Brand, Isabel Mattig, Sebastian Spethmann, Daniel Messroghli, Katrin Hahn, Ulf Landmesser, Bettina Heidecker   +8 more
doaj   +1 more source

Monitoring the Efficacy of Tafamidis in ATTR Cardiac Amyloidosis by MRI-ECV: A Systematic Review and Meta-Analysis

Tomography
Background: The usefulness of monitoring treatment effect of tafamidis using magnetic resonance imaging (MRI) extracellular volume fraction (ECV) has been reported.
Shingo Kato, Mai Azuma, Nobuyuki Horita, Daisuke Utsunomiya   +3 more
doaj   +1 more source