Results 91 to 100 of about 2,752 (180)

Holding Out for a Model: Rhomboid Superfamily in Vertebrate Development and Disease

Journal of Cellular Physiology, Volume 240, Issue 9, September 2025.
ABSTRACT The rhomboid superfamily, comprising both proteases and pseudoproteases, has emerged as a central regulator of membrane biology, mediating diverse functions including protein quality control, signal transduction, trafficking, and more. While molecular mechanisms of rhomboid activity have been well‐characterized in invertebrate and cell‐based ...
Saroj Gourkanti, Yazmin Munoz, Jacqueline Cheung, Rosa M. Chavez, Devanshi Agarwal, Taylor J. Schoen, Kristina Solorio‐Kirpichyan, Sonya E. Neal   +7 more
wiley   +1 more source

DataSheet4_Re-Expression of Tafazzin Isoforms in TAZ-Deficient C6 Glioma Cells Restores Cardiolipin Composition but Not Proliferation Rate and Alterations in Gene Expression.pdf

, 2022
Tafazzin—an acyltransferase—is involved in cardiolipin (CL) remodeling. CL is associated with mitochondrial function, structure and more recently with cell proliferation. Various tafazzin isoforms exist in humans.
Michael Linnebacher (180341), Daniela Peter (13146513), Stefan Simm (277838), Michael Lalk (117041), Uwe Lendeckel (4405486), Gayatri Jagirdar (13146510), Mathias Krohn (443089), Christian Scharf (104359), Matthias Elsner (3507983), Karen Methling (510762), Katrin Borucki (229301), Carmen Wolke (13146516)   +11 more
core   +1 more source

Cranial, Renal, and Skeletal Anomalies in a Fetus With a Pathogenic Variant in the TAFAZZIN Gene. [PDF]

Prenat Diagn
ABSTRACT Objective To report a case of a fetus with multiple congenital anomalies and suspected Barth syndrome, highlighting potential phenotypic expansion of the syndrome. Methods A 32‐year‐old G4P2011 patient was ...
Muir CR, Gilmore KL, Singh S, Vora NL.
europepmc   +3 more sources

DataSheet1_Re-Expression of Tafazzin Isoforms in TAZ-Deficient C6 Glioma Cells Restores Cardiolipin Composition but Not Proliferation Rate and Alterations in Gene Expression.PDF

, 2022
Tafazzin—an acyltransferase—is involved in cardiolipin (CL) remodeling. CL is associated with mitochondrial function, structure and more recently with cell proliferation. Various tafazzin isoforms exist in humans.
Michael Linnebacher (180341), Daniela Peter (13146513), Stefan Simm (277838), Michael Lalk (117041), Uwe Lendeckel (4405486), Gayatri Jagirdar (13146510), Mathias Krohn (443089), Christian Scharf (104359), Matthias Elsner (3507983), Karen Methling (510762), Katrin Borucki (229301), Carmen Wolke (13146516)   +11 more
core   +1 more source

Cardiac‐specific succinate dehydrogenase deficiency in Barth syndrome

EMBO Molecular Medicine, 2015
Barth syndrome (BTHS) is a cardiomyopathy caused by the loss of tafazzin, a mitochondrial acyltransferase involved in the maturation of the glycerophospholipid cardiolipin.
Jan Dudek, I‐Fen Cheng, Arpita Chowdhury, Katharina Wozny, Martina Balleininger, Robert Reinhold, Silke Grunau, Sylvie Callegari, Karl Toischer, Ronald JA Wanders, Gerd Hasenfuß, Britta Brügger, Kaomei Guan, Peter Rehling   +13 more
doaj   +1 more source

Cardiolipin biosynthesis and remodeling enzymes are altered during development of heart failure

Journal of Lipid Research, 2009
Cardiolipin (CL) is responsible for modulation of activities of various enzymes involved in oxidative phosphorylation. Although energy production decreases in heart failure (HF), regulation of cardiolipin during HF development is unknown.
Harjot K. Saini-Chohan, Michael G. Holmes, Adam J. Chicco, William A. Taylor, Russell L. Moore, Sylvia A. McCune, Diane L. Hickson-Bick, Grant M. Hatch, Genevieve C. Sparagna   +8 more
doaj   +1 more source

DataSheet3_Re-Expression of Tafazzin Isoforms in TAZ-Deficient C6 Glioma Cells Restores Cardiolipin Composition but Not Proliferation Rate and Alterations in Gene Expression.pdf

, 2022
Tafazzin—an acyltransferase—is involved in cardiolipin (CL) remodeling. CL is associated with mitochondrial function, structure and more recently with cell proliferation. Various tafazzin isoforms exist in humans.
Michael Linnebacher (180341), Daniela Peter (13146513), Stefan Simm (277838), Michael Lalk (117041), Uwe Lendeckel (4405486), Gayatri Jagirdar (13146510), Mathias Krohn (443089), Christian Scharf (104359), Matthias Elsner (3507983), Karen Methling (510762), Katrin Borucki (229301), Carmen Wolke (13146516)   +11 more
core   +1 more source

Table1_Re-Expression of Tafazzin Isoforms in TAZ-Deficient C6 Glioma Cells Restores Cardiolipin Composition but Not Proliferation Rate and Alterations in Gene Expression.XLSX

, 2022
Tafazzin—an acyltransferase—is involved in cardiolipin (CL) remodeling. CL is associated with mitochondrial function, structure and more recently with cell proliferation. Various tafazzin isoforms exist in humans.
Michael Linnebacher (180341), Daniela Peter (13146513), Stefan Simm (277838), Michael Lalk (117041), Uwe Lendeckel (4405486), Gayatri Jagirdar (13146510), Mathias Krohn (443089), Christian Scharf (104359), Matthias Elsner (3507983), Karen Methling (510762), Katrin Borucki (229301), Carmen Wolke (13146516)   +11 more
core   +1 more source

Identification of a Novel Gene Mutation in a Family With X-Linked Dilated Cardiomyopathy Barth Syndrome

Journal of Inborn Errors of Metabolism and Screening, 2015
Mutations in the tafazzin ( TAZ ) gene on chromosome Xq28 are responsible for the Barth syndrome (BTHS) phenotype resulting in a loss of function in the protein tafazzin involved in the transacylation of cardiolipin, an essential mitochondrial ...
Minal Borkar PhD, Sunita Bijarnia-Mahay DCH, DNB, MD, Sudha Kohli PhD, Monica Juneja MD, Yogesh Srivastava M.Sc, Renu Saxena PhD, Ishwar C. Verma FRCP   +6 more
doaj   +1 more source

Tafazzin (TAZ) promotes the tumorigenicity of cervical cancer cells and inhibits apoptosis

PLOS ONE, 2017
Tafazzin (TAZ) is often aberrantly expressed in some cancers, including rectal cancer and thyroid neoplasms. However, the function of TAZ in cervical cancer cells remains unknown. This study aims to explore the expression and function of TAZ in cervical cancer cells.
Mei Chen, Yuan Zhang, Peng-Sheng Zheng
openaire   +4 more sources