Results 171 to 179 of about 3,514 (179)
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Tafazzin knockdown causes hypertrophy of neonatal ventricular myocytes
American Journal of Physiology-Heart and Circulatory Physiology, 2010Mutation of the mitochondrial protein tafazzin causes dilated cardiomyopathy in Barth syndrome. We employed an adenovirus as a vector to transfer tafazzin small hairpin RNA (shRNA) into neonatal ventricular myocytes (NVMs) to investigate the effects of tafazzin knockdown. The tafazzin shRNA adenovirus consistently knocked down tafazzin mRNA and lowered
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Drosophila Mitochondrial Membrane‐bound Tafazzin Protein Is A Transacylase
The FASEB Journal, 2007Barth syndrome is an X‐linked mitochondria disorder with skeleton myopathy, cardiomyopathy and neutropenia, resulting from the tafazzin mutation. As demonstrated previously [Xu et al.: PNAS 103:11584, 2006], the mutation of full length Drosophila ...
Yang Xu +6 more
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Tafazzin knockdown interrupts cell cycle progression in cultured neonatal ventricular fibroblasts
American Journal of Physiology-Heart and Circulatory Physiology, 2013Mutation of the mitochondrial protein tafazzin causes dilated cardiomyopathy in Barth syndrome. Previous studies have shown that tafazzin knockdown promotes hypertrophy of neonatal cardiac myocytes. The current investigation was designed to show whether tafazzin knockdown affects cardiac fibroblast proliferation and collagen secretion, which contribute
Quan, He +3 more
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Tafazzin contributes to IgE‐mediated mast cell degranulation and cytokine secretion
The FASEB Journal, 2020Prevalence of allergic pathologies, such as food allergies, asthma, and atopic dermatitis, have been on the rise over the past several decades with approximately 40% of children in developed nations suffering one of these chronic inflammatory diseases. These pathologies, driven largely by
Aindriu R. R. Maguire +3 more
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Abstract 18250: Tafazzin-Knockdown Mice: Heart Mitochondrial Structure and Function
Circulation, 2013Barth syndrome is a genetic disorder with mutations in the tafazzin gene resulting in cardiomyopathy, hypotonia, growth delays, and cyclic neutropenia. Mitochondria have been examined for functional defects in Barth syndrome and defects found in oxidative phosphorylation, a decreased content and abnormal composition of cardiolipin, and an increased ...
Junhwas Kim +3 more
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Mögliche Ursache einer fetalen Herzinsuffizienz: TAFAZZIN-Genvariante
Ultraschall in der Medizin - European Journal of UltrasoundM. Rehn +5 more
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The role of cardiolipin in molecular assemblies of tafazzin
Mitochondrion, 2011Ashim Malhotra⁎ +3 more
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A linear algebra model of the tafazzin reaction
Chemistry and Physics of Lipids, 2008openaire +1 more source