Results 81 to 90 of about 3,514 (179)

Age‐Associated Dysregulation of Postsynaptic Mitochondria Perturbs Reinnervation Kinetics

Aging Cell, Volume 25, Issue 1, January 2026.
We show that aging results in postsynaptic mitochondrial loss at the neuromuscular junction and impaired muscle reinnervation. In vivo CRISPR knockout of mitochondrial genes, CHCHD10 and CHCHD2, in young muscles led to fragmented endplates, aberrant innervation, and impaired transcriptional maturation of sub‐synaptic myonuclei during regeneration ...
Steve D. Guzman, Paula M. Fraczek, Klimentini Itsani, Esraa K. Furati, Devin Juros, Grace Kenney, Gregorio Valdez, Joe V. Chakkalakal, Carlos A. Aguilar   +8 more
wiley   +1 more source

Mitochondrial cardiolipin metabolism controlled by tafazzin enables ferroptosis

AbstractMitochondria are important producers of reactive oxygen species, which are involved in triggering ferroptosis, a lipid peroxidation driven form of cell death. Paradoxically, in the rare inherited metabolic disease Barth Syndrome, we discovered a protection from erastin-induced ferroptosis, despite intrinsically elevated mitochondrial ROS levels.
Wohlfarter Y, Hagenbuchner J, Horzum U, Oemer G, Winter A, Seifert M, Schwärzler J, Kokot J, Hernansanz Agustín P, Juric V, Garcia Suoza LF, Talasz H, Enríquez Domínguez JA, Farhan H, Adolph TE, Weiss G, Zschocke J, Keller MA.   +17 more
europepmc   +2 more sources

Membrane Modulation and Cardiolipin Interaction of Small Molecules and Proteins [PDF]

, 2022
165 Seiten, Illustrationen ...
Kleinwächter, Isabel
core   +1 more source

Holding Out for a Model: Rhomboid Superfamily in Vertebrate Development and Disease

Journal of Cellular Physiology, Volume 240, Issue 9, September 2025.
ABSTRACT The rhomboid superfamily, comprising both proteases and pseudoproteases, has emerged as a central regulator of membrane biology, mediating diverse functions including protein quality control, signal transduction, trafficking, and more. While molecular mechanisms of rhomboid activity have been well‐characterized in invertebrate and cell‐based ...
Saroj Gourkanti, Yazmin Munoz, Jacqueline Cheung, Rosa M. Chavez, Devanshi Agarwal, Taylor J. Schoen, Kristina Solorio‐Kirpichyan, Sonya E. Neal   +7 more
wiley   +1 more source

Reduction in mRNA Expression of the Neutrophil Chemoattract Factor CXCL1 in Pseudomonas aeruginosa Treated Barth Syndrome B Lymphoblasts

Biology, 2023
Barth Syndrome (BTHS) is a rare X-linked genetic disease caused by a mutation in the TAFAZZIN gene, which codes for the protein tafazzin involved in cardiolipin remodeling.
Hana M. Zegallai, Kangmin Duan, Grant M. Hatch   +2 more
doaj   +1 more source

Ferroptosis in Pneumoconiosis: From Molecular and Cellular Mechanisms to Therapeutic Strategies

Med Research, Volume 1, Issue 2, Page 239-256, September 2025.
Targeting lung various cells to alleviate pneumoconiosis by suppressing ferroptosis. AAV9‐HGF, adeno‐associated virus‐hepatocyte growth factor; DFP, deferiprone; DHQ, dihydroquercetin; Fer‐1, ferrostatin‐1; IL‐1β, interleukin‐1β; NMN, nicotinamide mononucleotide; sh‐SLC39A14, shRNA targeting solute carrier family 39 member 14; si‐OC‐STAMP, siRNA ...
Mengli Yan, Jing Zhang, Gaili Ji, Xiaobin Fang, Chunheng Mo   +4 more
wiley   +1 more source

Monolysocardiolipin in cultured fibroblasts is a sensitive and specific marker for Barth Syndrome

Journal of Lipid Research, 2006
Barth Syndrome (BTHS) is an X-linked recessive disorder that results in abnormal metabolism of the mitochondrial phospholipid cardiolipin (CL). CLs are decreased and monolysocardiolipins (MLCLs), intermediates in CL metabolism, are increased in a variety
Michiel Adriaan van Werkhoven, David Ross Thorburn, Agi Kyra Gedeon, James Jonathon Pitt   +3 more
doaj   +1 more source

Mitochondria as Regulators of Nonapoptotic Cell Death in Cancer

MedComm, Volume 6, Issue 8, August 2025.
Mitochondrial fission and fusion are key processes in maintaining cellular health. Fission is driven by proteins like, Fis‐1, which recruits DRP‐1, to facilitate the division of mitochondria. Fusion, however, is mediated by mitofusion 1(MFN1), mitofusion 2(MFN2), and optic atrophy 1 (OPA1), which work together to merge mitochondria, allowing functional
Saloni Malla, Rabin Neupane, Saloni Sood, Noor Hussein, Mariam Abou‐Dahech, David Terrero, Charles R. Ashby Jr., R. Jayachandra Babu, Amit K. Tiwari   +8 more
wiley   +1 more source

Deficiency in Cardiolipin Reduces Doxorubicin-Induced Oxidative Stress and Mitochondrial Damage in Human B-Lymphocytes. [PDF]

PLoS ONE, 2016
Cardiolipin (CL) is an inner mitochondrial membrane phospholipid which plays an important role in mitochondrial function. Perturbation in CL biosynthesis alters mitochondrial bioenergetics causing a severe genetic disorder commonly known as Barth ...
Baikuntha Aryal, V Ashutosh Rao
doaj   +1 more source

Molecular aspects of WNT/Frizzled signalling in brain angiogenesis [PDF]

, 2017
The family of WNT lipoglycoproteins consists of 19 secreted proteins that are important for multiple cellular processes including cell proliferation, migration and fate.
Hot, Belma
core   +1 more source