A predictive model for canine dilated cardiomyopathy: a meta-analysis of Doberman Pinscher data [PDF]
, 2015 Dilated cardiomyopathy is a prevalent and often fatal disease in humans and dogs. Indeed dilated cardiomyopathy is the third most common form of cardiac disease in humans, reported to a ect approximately 36 individuals per 100,000 individuals.
Bland +27 more
core +6 more sources
Emerging Roles for Ciz1 in Cell Cycle Regulation and as a Driver of Tumorigenesis [PDF]
, 2016 Precise duplication of the genome is a prerequisite for the health and longevity of multicellular organisms. The temporal regulation of origin specification, replication licensing, and firing at replication origins is mediated by the cyclin-dependent ...
Copeland, Nikki A. +3 more
core +2 more sources
Monolysocardiolipin in cultured fibroblasts is a sensitive and specific marker for Barth Syndrome
Journal of Lipid Research, 2006 Barth Syndrome (BTHS) is an X-linked recessive disorder that results in abnormal metabolism of the mitochondrial phospholipid cardiolipin (CL). CLs are decreased and monolysocardiolipins (MLCLs), intermediates in CL metabolism, are increased in a variety
Michiel Adriaan van Werkhoven +3 more
doaj +1 more source
Age‐Associated Dysregulation of Postsynaptic Mitochondria Perturbs Reinnervation Kinetics
Aging Cell, Volume 25, Issue 1, January 2026.We show that aging results in postsynaptic mitochondrial loss at the neuromuscular junction and impaired muscle reinnervation. In vivo CRISPR knockout of mitochondrial genes, CHCHD10 and CHCHD2, in young muscles led to fragmented endplates, aberrant innervation, and impaired transcriptional maturation of sub‐synaptic myonuclei during regeneration ...
Steve D. Guzman +8 more
wiley +1 more source
Outlook Magazine, Autumn 2011 [PDF]
, 2011 https://digitalcommons.wustl.edu/outlook/1184/thumbnail ...
core +1 more source
Holding Out for a Model: Rhomboid Superfamily in Vertebrate Development and Disease
Journal of Cellular Physiology, Volume 240, Issue 9, September 2025.ABSTRACT The rhomboid superfamily, comprising both proteases and pseudoproteases, has emerged as a central regulator of membrane biology, mediating diverse functions including protein quality control, signal transduction, trafficking, and more. While molecular mechanisms of rhomboid activity have been well‐characterized in invertebrate and cell‐based ...
Saroj Gourkanti +7 more
wiley +1 more source
Mitochondrial Cardiomyopathies [PDF]
, 2016 Mitochondria are found in all nucleated human cells and perform a variety of essential functions, including the generation of cellular energy. Mitochondria are under dual genome control.
Ayman W. El-Hattab, Fernando Scaglia
core +2 more sources
Loss of tafazzin in yeast leads to increased oxidative stress during respiratory growth [PDF]
Molecular Microbiology, 2008 SummaryThe tafazzin (TAZ) gene is highly conserved from yeast to humans, and the yeast taz1 null mutant shows alterations in cardiolipin (CL) metabolism, mitochondrial dysfunction and stabilization of supercomplexes similar to those found in Barth syndrome, a human disorder resulting from loss of tafazzin.
Shuliang, Chen +2 more
openaire +2 more sources
Deficiency in Cardiolipin Reduces Doxorubicin-Induced Oxidative Stress and Mitochondrial Damage in Human B-Lymphocytes. [PDF]
PLoS ONE, 2016 Cardiolipin (CL) is an inner mitochondrial membrane phospholipid which plays an important role in mitochondrial function. Perturbation in CL biosynthesis alters mitochondrial bioenergetics causing a severe genetic disorder commonly known as Barth ...
Baikuntha Aryal, V Ashutosh Rao
doaj +1 more source
Ferroptosis in Pneumoconiosis: From Molecular and Cellular Mechanisms to Therapeutic Strategies
Med Research, Volume 1, Issue 2, Page 239-256, September 2025.Targeting lung various cells to alleviate pneumoconiosis by suppressing ferroptosis. AAV9‐HGF, adeno‐associated virus‐hepatocyte growth factor; DFP, deferiprone; DHQ, dihydroquercetin; Fer‐1, ferrostatin‐1; IL‐1β, interleukin‐1β; NMN, nicotinamide mononucleotide; sh‐SLC39A14, shRNA targeting solute carrier family 39 member 14; si‐OC‐STAMP, siRNA ...
Mengli Yan +4 more
wiley +1 more source