Results 51 to 60 of about 1,405,161 (353)

Knowledge and perception regarding effectiveness in influenza vaccines among General Practitioners in Germany: A national survey

open access: yesVaccine: X, 2022
Objectives: To understand physicians’ knowledge and perception regarding the effectiveness of influenza vaccines and to communicate the importance of understanding the differences in terms of vaccine efficacy and vaccine effectiveness.
Sanjay Hadigal, Joseph Cook
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Late-season corn stalk nitrate measurements across the US Midwest from 2006 to 2018

open access: yesScientific Data, 2023
The late-season Corn Stalk Nitrate Test (CSNT) is a well-known tool to help evaluate the after-the-fact performance of nitrogen management. The CSNT has the unique ability to distinguish between optimal and excessive corn nitrogen status, which makes it ...
Anabelle Laurent   +11 more
doaj   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Fibrosarcoma Originating in the Tail of a Cat

open access: yesClinical Case Reports
Radiographic–pathologic correlation is essential for accurate diagnosis of skeletal tumors. Clinicians are encouraged to submit radiographic or CT images together with biopsy or cytological samples from bone lesions to facilitate accurate interpretation.
Masashi Yuki   +3 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

The Tail of the Late Jurassic Sauropod Giraffatitan brancai: Digital Reconstruction of Its Epaxial and Hypaxial Musculature, and Implications for Tail Biomechanics

open access: yesFrontiers in Earth Science, 2020
Dinosaur locomotion and biomechanics, especially of their pelvic girdles and hindlimbs, have been analyzed in numerous studies. However, detailed volumetric musculoskeletal models of their tails are rarely developed.
Verónica Díez Díaz   +6 more
doaj   +1 more source

Characteristics of biter and victim piglets apparent before a tail biting outbreak

open access: yes, 2011
Little is known about the characteristics of biters and victims before the appearance of a tail-biting outbreak in groups of pigs. This study aimed to characterise biters and victims (according to gender and performance) and to quantify their behavioural
Kemp, B.   +5 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

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