Results 71 to 80 of about 1,405,161 (353)

How Fat is the Top Tail of the Wealth Distribution?

Social Science Research Network, 2018
The US Survey of Consumer Finances (SCF) and the Eurosystem’s Household Finance and Consumption Survey (HFCS) provide evidence that wealth is heavily concentrated at the upper tail of the wealth distribution.
P. Vermeulen
semanticscholar   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Activation of Marck-like Genes and Proteins During Initial Phases of Regeneration in the Amputated Tail and Limb of the Lizard Podarcis muralis

Journal of Developmental Biology
Molecules involved in the activation of regeneration in reptiles are almost unknown. MARCK-like proteins are indicated to activate regeneration in some amphibians and fish, and it would be important to know whether this is a general process also present ...
Lorenzo Alibardi
doaj   +1 more source

Helicopter tail rotor thrust and main rotor wake coupling in crosswind flight

, 2010
The tail rotor of a helicopter with a single main rotor configuration can experience a significant reduction in thrust when the aircraft operates in crosswind flight. Brown’s vorticity transport model has been used to simulate a main rotor and tail rotor
Fletcher, Timothy M., Timothy M. Fletcher, Richard E. Brown, Brown, Richard   +3 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Centres of rotation and osteological constraints on caudal ranges of motion in the sauropod dinosaur Giraffatitan brancai

Royal Society Open Science
Archosaur tails are important appendages, not only for their biomechanical function but also for being behavioural tools that help the animal communicate and interact with its environment.
Verónica Díez Díaz, Pasha A. van Bijlert, William Irvin Sellers, Mathew J. Wedel, Daniela Schwarz   +4 more
doaj   +1 more source

A longitudinal study of the effects of providing straw at different stages of life on tail-biting and other behaviour in commercially housed pigs [PDF]

, 2011
Tail-biting (TB) is a welfare concern. Recent studies indicate that early provision of straw may help prevent TB, however, many of these studies were carried out on small groups of pigs and may have limited applicability to commercial farms.
Mendl, M. (Michael), Poppy Statham, Statham, Poppy, Green, LE, Mendl, Michael, Green, Laura E., Laura Green, Statham, P, Mendl, M, Green, Laura; id_orcid, Michael Mendl   +10 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Main rotor-tail rotor intraction and its implications for helicopter directional control

, 2008
Aerodynamic interference between the main and tail rotor can have a strong negative influence on the flight mechanics of a conventional helicopter. Significant unsteadiness in the tail rotor loading is encountered under certain flight conditions, but the
Fletcher, Timothy M., Brown, R.E., Fletcher, T.M.   +2 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source