Results 91 to 100 of about 2,223,882 (330)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Tail dependence networks of global stock markets
International Journal of Finance and Economics, 2018 The Pearson correlation coefficient is used by many researchers to construct complex financial networks. However, it is difficult to capture the structural characteristics of financial markets that have extreme fluctuations.
Fenghua Wen, Xin Yang, Wei‐Xing Zhou
semanticscholar +1 more source
On the Tail Behavior of Sums of Dependent Risks [PDF]
ASTIN Bulletin, 2006 The tail behavior of sums of dependent risks was considered by Wüthrich (2003) and by Alink et al. (2004, 2005) in the case where the variables are exchangeable and connected through an Archimedean copula model. It is shown here how their result can be extended to a broader class of dependence structures using multivariate extreme-value theory.
Barbe, Philippe +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
برنامهریزی و بودجه, 2022 This paper examines the dependence structure between two currencies (Yuan and Euro) before and after Yuan joins the SDR basket. To this end, we propose SJC copula Time-varying approach for the daily closing price of these currencies for the period 2005 ...
Nasser Khiabani, Shadi Bozorg
doaj
Tail dependence under sample failures [PDF]
Теория вероятностей и ее применения, 2019 При сборе данных иногда встречаются ситуации, препятствующие ему, что приводит к пропускам в данных. Это может оказать влияние на последующие статистические выводы, в особенности, если исследование касается экстремальных значений, информация о которых всегда более скудна.
Ferreira, Marta Susana, Ferreira, H.
openaire +3 more sources
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
ANALYSIS OF TAIL DEPENDENCE STRUCTURE IN GLOBAL FINANCIAL MARKETS
Quantitative Methods in Economics, 2014 The identification of tail (in)dependencies has drawn major attention in empirical financial studies. We concern on the structure of dependence which refers to dependence as symmetric or asymmetric, tail_x0002_dependent or tail-independent.
Grażyna Trzpiot, Justyna Majewska
doaj
Tail dependence of recursive max-linear models with regularly varying noise variables [PDF]
, 2017 Recursive max-linear structural equation models with regularly varying noise variables are considered. Their causal structure is represented by a directed acyclic graph (DAG). The problem of identifying a recursive max-linear model and its associated DAG
Nadine Gissibl, C. Kluppelberg, M. Otto
semanticscholar +1 more source