Results 111 to 120 of about 1,282,215 (298)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Extremal dependence in European capital markets [PDF]
For a sample of six countries with dirty/free float regimes over 1999-2002––the United States, Japan, the Czech Republic, Poland, Switzerland, and the United Kingdom, we investigate whether paired currencies exhibit a pattern of asymptotic dependence on ...
Viviana Fernández
core
Multivariate tail dependence: further insights with an application to the Spanish banking sector
Dependence ModelingExtending bivariate dependence concepts to higher dimensions is a challenging but essential task for a comprehensive understanding of multivariate dependence.
Durante Fabrizio +3 more
doaj +1 more source
Tail behavior of a sum of two dependent and heavy-tailed distributions
Journal of Statistics and Management Systems, 2018 We consider the problem of a sum of two dependent and heavy tailed distributions through the C-convolution.
openaire +4 more sources
Wave tails in time-dependent backgrounds [PDF]
Physical Review D, 2002 It is well-known that waves propagating under the influence of a scattering potential develop ``tails''. However, the study of late-time tails has so far been restricted to time-independent backgrounds. In this paper we explore the late-time evolution of spherical waves propagating under the influence of a {\it time-dependent} scattering potential.
openaire +2 more sources
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Copulas, stable tail dependence functions, and multivariate monotonicity
Dependence Modeling, 2019 For functions of several variables there exist many notions of monotonicity, three of them being characteristic for resp. distribution, survival and co-survival functions. In each case the “degree” of monotonicity is just the basic one of a whole scale.
Ressel Paul
doaj +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
On Tail Index Estimation for Dependent, Heterogenous Data [PDF]
In this paper we analyze the asymptotic properties of the popular distribution tail index estimator by B. Hill (1975) for possibly heavy- tailed, heterogenous, dependent processes.
Jonathan B. Hill
core
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source