Results 111 to 120 of about 21,200 (250)

Understanding extracellular vesicle biology, isolation, and characterization: The theory of EV‐erything

Periodontology 2000, EarlyView.
Abstract Background Extracellular vesicles (EVs), especially exosomes, are nanoparticles increasingly recognized as key regulators of intercellular communication in both physiological and pathological aspects. Despite rapid progress, inconsistencies in nomenclature, isolation, and characterization continue to restrict translational advancement.
Paras Ahmad, Nima Farshidfar, Nathan E. Estrin, Yulan Wang, Yufeng Zhang, Anton Sculean, Richard J. Miron   +6 more
wiley   +1 more source

One day of environment‐induced heat stress causes injury to the murine kidney

Experimental Physiology, EarlyView.
Abstract Environment‐induced heat stress (EIHS) results from sustained body temperature elevation owing to prolonged exposure to heat and humidity. We hypothesized that EIHS would cause kidney injury and cellular dysfunction. To test this hypothesis, female C57 mice were exposed to EIHS (n = 14; 37.6°C, 42.0% relative humidity) or thermoneutral (TN ...
Melissa Roths, Alyona Michael, Zachary J. Schlader, Joshua T. Selsby   +3 more
wiley   +1 more source

Pathophysiology of the gut–eye axis in a Sjögren's disease‐like dry eye mouse model: An exploratory evaluation of dietary heat‐treated Enterococcus faecalis FK‐23

Experimental Physiology, EarlyView.
Abstract Sjögren's disease is an autoimmune disease characterized by severe dry eye, but its pathophysiology remains unclear. Non‐obese diabetic (NOD) mice develop Sjögren's disease‐like dry eye prior to the onset of diabetes. Although intestinal immune abnormalities precede diabetes in NOD mice, their relationship to dry eye remains poorly understood.
Kenji Goto, Shigekazu Takemura, Yukiko Minamiyama, Toshikazu Yoshikawa   +3 more
wiley   +1 more source

Anatomical and functional mapping of vagal nociceptive sensory nerve subsets innervating the mouse lower airways by intersectional genetics

The Journal of Physiology, EarlyView.
Abstract figure legend We used an intersectional approach with recombinase‐expressing mice and adeno‐associated virus to map and modulate distinct nociceptive afferents in the vagal ganglia. TRPV1+P2X2+ neurons resided in the nodose ganglion (N), innervated the lungs (many projected into the alveoli) but not the trachea, and projected to the nucleus ...
Mayur J. Patil, Justin Shane Hooper, Seol‐Hee Kim, Parmvir K. Bahia, Nika Pavelkova, Sanjay S. Nair, Teresa S. Darcey, Karina V. Lurye, Meghana Madaram, Jailene Fiallo, Stephen H. Hadley, Thomas E. Taylor‐Clark   +11 more
wiley   +1 more source

Preeclampsia‐derived small extracellular vesicles disrupt blood–brain barrier integrity and activate glial cells in vitro

The Journal of Physiology, EarlyView.
Abstract figure legend This study assessed the impact of plasma‐derived small extracellular vesicles (sEVs) from healthy pregnant women and those diagnosed with late‐onset preeclampsia (PE) on the blood–brain barrier (BBB) integrity and glial cell response. PE patients had higher sEV concentrations than healthy controls.
Julián Henao‐Restrepo, José M. Murrieta‐Coxca, Christian Schmeer, Lingyu Wei, Frank Steiniger, Tanja Groten, Udo R. Markert, Diana M. Morales‐Prieto   +7 more
wiley   +1 more source

EasyVoid: A Handheld Coandă Effect Uroflowmeter for Accurate and Portable Measurement of Urinary Flow Dynamics. [PDF]

IEEE J Transl Eng Health Med
Chang R, Chen YC, Chen HW, Zeng RH, Prakash M.   +4 more
europepmc   +1 more source

Regional electrical differences and arrhythmia in the rat atria: Role of sympathetic nerve distribution and function

The Journal of Physiology, EarlyView.
Abstract figure legend Atrial fibrillation commonly develops in the left atrium and pulmonary veins (PVs), and can be triggered by sympathetic nerve activity. Here, we examined regional atrial differences in sympathetic nerve distribution and function in the rat.
James Saleeb‐Mousa, Manish Kalla, Neil Herring, Christopher O'Shea, Andrew M. Coney, Keith L. Brain, Andrew P. Holmes   +6 more
wiley   +1 more source

Quantification of Spatial Patterns of Microtubule Transport by Kinesin-1 Head and Tail. [PDF]

Bio Protoc
Basu J, Singh K, Jannasch A, Athale CA.
europepmc   +1 more source

Old dog, new trick: Charybdotoxin as a novel ryanodine receptor blocker

The Journal of Physiology, EarlyView.
Abstract figure legend The peptide toxin charybdotoxin (ChTx) from the scorpion Leiurus quinquestriatus was tested on single‐channel currents of the ryanodine receptor incorporated into planar lipid bilayers. The structure–function relationship of ChTx was investigated using toxin variants generated by isosteric substitutions of the basic amino acids ...
Zsuzsanna Édua Magyar, Judit Hevesi, Frigyes Mészáros, Zsolt Bozsó, János Szolomájer, Gábor Tóth, György Panyi, Péter Enyedi, Zoltán Varga, Zoltán Pethő, János Almássy   +10 more
wiley   +1 more source

Dynamic analysis of misalignment modelling with flexible damped coupling in rotor shaft system using classical approach. [PDF]

Sci Rep
Malgi H, Chandraker S, Aggarwal M, Dutt JK, Mehar K.   +4 more
europepmc   +1 more source