Results 41 to 50 of about 8,350 (265)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Research on Basic Performance and Aging Durability of Iron Tailings Asphalt Mixture

Kuangchan zonghe liyong, 2022
In order to avoid excessive use of natural sand and gravel materials as aggregates of asphalt mixtures and to comply with the strategic policy of green development, solid waste iron tailings are used to replace sand and gravel materials to prepare a new ...
Lianping Zhao, Shaoju Hao, Jing Ma
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Extreme Geochemical Conditions and Dispersal Limitation Retard Primary Succession of Microbial Communities in Gold Tailings

Frontiers in Microbiology, 2018
Microbial community succession in tailings materials is poorly understood at present, and likely to be substantially different from similar processes in natural primary successional environments due to the unusual geochemical properties of tailings and ...
Talitha C. Santini, Talitha C. Santini, Maija Raudsepp, Jessica Hamilton, Jasmine Nunn   +4 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Performance Comparison between Neutralization Tailings and Flotation Tailings Used for Backfill Mix and Mechanism Analysis

Advances in Materials Science and Engineering, 2016
A comparison test of different tailings used for underground backfill was conducted, using neutralized tailings from BIOX and flotation tailings of Jinfeng Mine.
Bin Han, Wei Sun, Shaofeng Yu, Chao Liu, Song Yao, Jianxun Wu   +5 more
doaj   +1 more source

Optimization of the effect and formulation of different coarse aggregates on performance of the paste backfill condensation

工程科学学报, 2020
Hydration and setting time of paste-like backfill slurry in the Gansu Province’s Jinchuan copper and nickel mine is slow, and the degree of segregation of coarse aggregate is high, seriously affecting the quality of cemented paste backfill. In this paper,
Sheng-hua YIN, Jia-ming LIU, Wei CHEN, Long ZOU, Yong-yuan KOU, Xi-wen LI   +5 more
doaj   +1 more source

Performance Characteristics of Cemented Tailings Containing Crumb Rubber as a Filling Material

Advances in Materials Science and Engineering, 2022
Increasing amounts of tailings and waste rubber tires have caused threats to the environment. In order to reuse these solid wastes, this study proposed a cemented tailings material containing crumb rubber recovered from waste tires.
Zhuoqun Yu, Nan Qin, Sa Huang, Jianguang Li, Yongyan Wang   +4 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source